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View Structure Prediction Details

Protein: swi6
Organism: Schizosaccharomyces pombe
Length: 328 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for swi6.

Description E-value Query
Range		 Subject
Range
gi|109129375 - gi|109129375|ref|XP_001108466.1| PREDICTED: similar to chromodomain protein, Y-like 2 [Macaca mulatt...
 169.0 [0..74] [313..97]
gi|32479352 - gi|32479352|gb|AAP83841.1| chromodomain Y-like protein 2 [Macaca fascicularis]
 167.0 [0..79] [313..5]
CDYL2 - chromodomain protein, Y-like 2
 164.0 [0..79] [313..5]
gi|114663884 - gi|114663884|ref|XP_523432.2| PREDICTED: chromodomain protein, Y-like 2 [Pan troglodytes]
 164.0 [0..83] [313..49]
gi|74206467 - gi|74206467|dbj|BAE24934.1| unnamed protein product [Mus musculus]
 158.0 [0..79] [313..5]
CHP2_SCHPO - Chromo domain-containing protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=chp2 PE...
chp2 - chromodomain protein 2
 157.0 [0..4] [324..94]
gi|109508956 - gi|109508956|ref|XP_001078221.1| PREDICTED: similar to chromodomain Y-like protein 2 [Rattus norvegi...
 153.0 [0..83] [313..7]

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Predicted Domain #1
Region A:
Residues: [1-76] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKGGVRSYR RSSTSKRSVI DDDSEPELPS MTKEAIASHK ADSGSSDNEV ESDHESKSSS  60
   61 KKLKENAKEE EGGEEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [77-172] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEDEYVVEKV LKHRMARKGG GYEYLLKWEG YDDPSDNTWS SEADCSGCKQ LIEAYWNEHG  60
   61 GRPEPSKRKR TARPKKPEAK EPSPKSRKTD EDKHDK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.30103
Match: 2b2uA
Description: Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
chromatin binding 3.1924157640698 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
methylated histone residue binding 2.71235155233989 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
histone binding 1.48525673080866 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [173-255] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSNEKIEDVN EKTIKFADKS QEEFNENGPP SGQPNGHIES DNESKSPSQK ESNESEDIQI  60
   61 AETPSNVTPK KKPSPEVPKL PDN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [256-328] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RELTVKQVEN YDSWEDLVSS IDTIERKDDG TLEIYLTWKN GAISHHPSTI TNKKCPQKML  60
   61 QFYESHLTFR ENE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.154902
Match: 1e0bA
Description: Heterochromatin protein 1, HP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
chromatin binding 3.1924157640698 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
methylated histone residue binding 2.71235155233989 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
histone binding 1.48525673080866 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle