Protein Overview: chp2

General Information:
Name(s) found:	chp2 / SPBC16C6.10 [Sanger Pombe]
Description(s) found: Found 19 descriptions. SHOW ALL	chromodomain protein 2 [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	380 amino acids
Gene Ontology:
Cellular Component:	mating-type region heterochromatin [TAS] nucleus [IDA] nuclear chromatin [ISS] nuclear telomeric heterochromatin [TAS] spindle pole body [IDA] centromeric heterochromatin [TAS]
Biological Process:	chromatin remodeling [RCA] chromatin silencing at centromere [IMP] chromatin silencing at rDNA [IMP] chromatin assembly or disassembly [IEA] chromatin silencing at silent mating-type cassette [IMP] chromatin silencing at telomere [IMP]
Molecular Function:	DNA binding [IEA] chromatin binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKSADLDLM NSIISESDEN FSPPPFTVEE AENSINNKSS TASLESPQNG SWHPSLYGLS  60
   61 VPEKTHIQNS LDLYSHGNSG SQKTHNVSFS CEIRKVKSSK LSPISNMEDS EDKKEEDESS 120
  121 SYKNEFKSSS SASVSSNFEK TSGSDDHNSQ SPVPLNEGFE YIASSGSEDK NSDEEFAVEM 180
  181 ILDSRMKKDG SGFQYYLKWE GYDDPSDNTW NDEEDCAGCL ELIDAYWESR GGKPDLSSLI 240
  241 RLTRSRARSS NEASYVEKDE SSNSDDSISY KRRRSRNAAN RITDYVDSDL SESSMKEKQS 300
  301 KIEKYMKSDK SSKNFKPPFQ KKSWEDLVDC VKTVQQLDNG KLIAKIKWKN GYVSTHDNII 360
  361 IHQKCPLKII EYYEAHIKFT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..171]	MSA	3.126997	View MSA. No confident structure predictions are available.
2	View Details	[172..313]	PSI-BLAST	6.522879	Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
3	View Details	[314..380]	PSI-BLAST	11.045757	Heterochromatin protein 1, HP1

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
transcription repressor activity	4.08500855631983	bayes_pls_golite062009
transcription regulator activity	3.64390820819794	bayes_pls_golite062009
chromatin binding	3.1924157640698	bayes_pls_golite062009
methylated histone residue binding	3.18095357415772	bayes_pls_golite062009
binding	3.06758476214113	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
protein binding	1.61683263008775	bayes_pls_golite062009
histone binding	1.37812404837999	bayes_pls_golite062009
general transcriptional repressor activity	0.75184432495983	bayes_pls_golite062009
transcription corepressor activity	0.294457188332415	bayes_pls_golite062009
satellite DNA binding	0.158790063943709	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009
transcription activator activity	0.136090220479238	bayes_pls_golite062009

3

Term	Confidence	Notes
transcription repressor activity	4.08500855631983	bayes_pls_golite062009
transcription regulator activity	3.64390820819794	bayes_pls_golite062009
chromatin binding	3.1924157640698	bayes_pls_golite062009
methylated histone residue binding	3.18095357415772	bayes_pls_golite062009
binding	3.06758476214113	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
protein binding	1.61683263008775	bayes_pls_golite062009
histone binding	1.37812404837999	bayes_pls_golite062009
general transcriptional repressor activity	0.75184432495983	bayes_pls_golite062009
transcription corepressor activity	0.294457188332415	bayes_pls_golite062009
satellite DNA binding	0.158790063943709	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009
transcription activator activity	0.136090220479238	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle