Protein Overview: swi6

General Information:
Name(s) found:	swi6 / SPAC664.01c [Sanger Pombe]
Description(s) found: Found 22 descriptions. SHOW ALL	chromodomain protein Swi6 [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	328 amino acids
Gene Ontology:
Cellular Component:	mating-type region heterochromatin [IDA] nucleus [IDA] nuclear telomeric heterochromatin [IDA] spindle pole body [IDA] centromeric heterochromatin [TAS]
Biological Process:	sister chromatid cohesion [IGI] chromatin remodeling [RCA] chromatin silencing at centromere [IMP] chromatin assembly or disassembly [IEA] chromatin silencing at silent mating-type cassette [IMP] donor selection [IMP] chromatin silencing at telomere [IMP] mating type switching [IMP] cellular protein localization [IGI ]
Molecular Function:	protein binding [IPI ] chromatin binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKGGVRSYR RSSTSKRSVI DDDSEPELPS MTKEAIASHK ADSGSSDNEV ESDHESKSSS  60
   61 KKLKENAKEE EGGEEEEEDE YVVEKVLKHR MARKGGGYEY LLKWEGYDDP SDNTWSSEAD 120
  121 CSGCKQLIEA YWNEHGGRPE PSKRKRTARP KKPEAKEPSP KSRKTDEDKH DKDSNEKIED 180
  181 VNEKTIKFAD KSQEEFNENG PPSGQPNGHI ESDNESKSPS QKESNESEDI QIAETPSNVT 240
  241 PKKKPSPEVP KLPDNRELTV KQVENYDSWE DLVSSIDTIE RKDDGTLEIY LTWKNGAISH 300
  301 HPSTITNKKC PQKMLQFYES HLTFRENE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..76]	deduced	N/A	No confident structure predictions are available.
2	View Details	[77..172]	PSI-BLAST	9.30103	Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
3	View Details	[173..255]	deduced	N/A	No confident structure predictions are available.
4	View Details	[256..328]	PSI-BLAST	21.154902	Heterochromatin protein 1, HP1

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
transcription repressor activity	4.08500855631983	bayes_pls_golite062009
transcription regulator activity	3.64390820819794	bayes_pls_golite062009
chromatin binding	3.1924157640698	bayes_pls_golite062009
binding	3.06758476214113	bayes_pls_golite062009
methylated histone residue binding	2.71235155233989	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
protein binding	1.61683263008775	bayes_pls_golite062009
histone binding	1.48525673080866	bayes_pls_golite062009
DNA-dependent ATPase activity	0.998957812785999	bayes_pls_golite062009
general transcriptional repressor activity	0.75184432495983	bayes_pls_golite062009
DNA helicase activity	0.726970683178132	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.494788451379878	bayes_pls_golite062009
transcription corepressor activity	0.294457188332415	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009
transcription activator activity	0.136090220479238	bayes_pls_golite062009

3

No functions predicted.

4

Term	Confidence	Notes
transcription repressor activity	4.08500855631983	bayes_pls_golite062009
transcription regulator activity	3.64390820819794	bayes_pls_golite062009
chromatin binding	3.1924157640698	bayes_pls_golite062009
binding	3.06758476214113	bayes_pls_golite062009
methylated histone residue binding	2.71235155233989	bayes_pls_golite062009
nucleic acid binding	2.19167058827256	bayes_pls_golite062009
DNA binding	2.05514577638135	bayes_pls_golite062009
protein binding	1.61683263008775	bayes_pls_golite062009
histone binding	1.48525673080866	bayes_pls_golite062009
DNA-dependent ATPase activity	0.998957812785999	bayes_pls_golite062009
general transcriptional repressor activity	0.75184432495983	bayes_pls_golite062009
DNA helicase activity	0.726970683178132	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.494788451379878	bayes_pls_golite062009
transcription corepressor activity	0.294457188332415	bayes_pls_golite062009
catalytic activity	0.14067200158938	bayes_pls_golite062009
transcription activator activity	0.136090220479238	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle