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Protein Overview: rga3

General Information:
Name(s) found: rga3 / SPAC29A4.11 [Sanger Pombe]
Description(s) found:
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  • gi|7493289|pir||T38478 RhoGAP/LIM domain protein - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|31076877|sp|O14014.1|RGA3_SCHPO RecName: Full=Probable Rho-type GTPase-activating protein 3 [NCBI NR]
  • gi|2239221|emb|CAB10138.1| Rho-type GTPase activating protein Rga3 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115783|ref|NP_594871.1| GTPase activating protein Rga3 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • GTPase activating protein Rga3 [Sanger Pombe]
  • Probable Rho-type GTPase-activating protein 3 OS=Schizosaccharomyces pombe GN=rga3 PE=2 SV=1 [Swiss-Prot]
  • GTPASE ACTIVATOR; RHOGAP DOMAIN; LIM DOMAIN; REQUIRED FOR RHO-LIKE GTPASES; SUBCELLULAR LOCALIZATION OF GFP FUSION- CELL POLE AND SEPTUM; SIMILAR TO S. CEREVISIAE RGA1: O14014;Q9USB8; [pompepVF.fasta]
  • RHOGAP/LIM DOMAIN PROTEIN; PUTATIVE GTPASE-ACTIVATOR PROTEIN FOR RHO-LIKE GTPASES; SUBCELLULAR LOCALIZATION OF GFP FUSION; CELL POLE AND SEPTUM: O14014;Q9USB8; [pompepV13]
  • Probable Rho-type GTPase-activating protein 3 [pompep4896]
  • |rga3||GTPase activator [pompepnew.fasta]
  • |rga3||GTPase activating protein|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • RhoGAP/LIM domain protein [Schizosaccharomyces pombe]gi|2239221|emb|CAB10138.1| SPAC29A4.11 [Schizosaccharomyces pombe]gi|31076877|sp|O14014|RGA3_SCHPO Probable Rho-type GTPase-activating protein 3gi|7493289|pir||T38478 RhoGAP/LIM domain protein - fiss [nrdb_11152004_Chlamydomonas]
  • (O14014) Probable Rho-type GTPase-activating protein 3 [pompep4896_normal_reversed]
  • |rga3||Rho-type GTPase activating protein Rga3|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC29A4.11 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC29A4.11 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • RhoGAP/LIM domain protein - fission yeast (Schizosaccharomyces pombe) [nr-271106-contam.fasta]
  • Probable Rho-type GTPase-activating protein 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rga3 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 969 amino acids

    Gene Ontology:
    Cellular Component: cell division site [IDALink to PubMed article]
    cell tip [IDALink to PubMed article]
    barrier septum [IDALink to PubMed article]
    cell cortex of cell tip [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: regulation of Rho GTPase activity [ISS]
    Molecular Function: zinc ion binding [IEA]
    Rho GTPase activator activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIFRKSISKS PSSKGSTVCF RCGQAFQRRE TPISFGGHMW HKDCFCCTKC DKGLEHSDQM  60
   61 LVQTSDGRPV CSSCAHTCTA CRMRIKDYAL MSGYDSYHRE CFRCHDCRKQ IIDSNFKRDN 120
  121 RTIFCNDCKQ VRHPSRSSDE SADYHNFEVD VTIKPTETKS SVESNKSLSI EIMSPQKPPL 180
  181 SPFGGSRDRL VSETPTNMSQ AEGGNVPNDG QDSNLASNSA DSLLPSAKNR SFSSFTSFES 240
  241 PMKYDDSFFP ISPSISPLQK VNKQQQIESP TATFPLSKNT WKNRFHTFHK QSFTPVNDSS 300
  301 SSDSLKPTIN EEALDDFAGS ASPYKTMSLT DRAEPIVMNG HMRSLHNATS PFRPFSPSYR 360
  361 SSDTHSPRTR SPNVQTHKKT SSQPSDLSSF AQLLSPPQVL SPKPNGGGHK SFRHSHSLSE 420
  421 TSQQTLVPSL GSNGEYHLPT NDHSSTPAQS ERDSDVEELR EQLENLTALT KKLSERLSSS 480
  481 TFDNSKFIRT EDKDTVRSAK LEICEKFFSF ADVTDDPTLK DPKHQDLVAA ANAYMAMLRE 540
  541 SYGTEINNLL ERRNELLDDY NNVQKILNES LEASVHLNTK NLELADLNNN LVKQIQHRVP 600
  601 PENQSNLEHT ITTSSKNTTS SINPLTAVSS NSGQSSGRPG PLSPNLNVTT RIDIKGKKGS 660
  661 MHLQPRDVNR KVPFKSMHTK SKSADPVVGN EDRTQCDHVF HVNAIFKPSR CYICSESVWG 720
  721 SELRCFHCSI SCHSRCLKRL FAESEHEKTM SETVSENSKW MPEMPTRMPP PGPSPTMFGR 780
  781 SLENQLKIEG SVLPQVIAMC VSCVDAHGLE VEGIYRISGS ASQVRVLVDE FENGSIRMEH 840
  841 LTSDLFACTS VLKTYLHRLP EPVIPGTQYE ELLEAEKIEK EEEKIERVVE VMKTLHPAHL 900
  901 SVFRFLIAHL GRVCKHAEKN LMNSKNVSTV FAPTLMRDKV NRFDLQHATK KSTALQFMLD 960
  961 NVDKILHNL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..155] PSI-BLAST 39.0 No description for 2i13A was found.
    2 View Details [156..448] deduced N/A No confident structure predictions are available.
    3 View Details [449..969] PSI-BLAST 78.522879 Crystal Structure of the Human Beta2-Chimaerin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  4.48279904625182 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • binding
    		•  2.15139804299723 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.33740973673697 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.2323381312171 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.08705453507613 bayes_pls_golite062009
  • diacylglycerol binding
    		•  1.02792245495259 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  0.967362611034944 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • actin binding
    		•  0.542172162219949 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • Rho GTPase binding
    		•  0.150587174126097 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0455432286632499 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle