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Protein Overview: dis2

General Information:
Name(s) found: dis2 / SPBC776.02c [Sanger Pombe]
Description(s) found:
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  • gi|532664|gb|AAA74731.1| protein phosphatase 1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|4176519|emb|CAA22875.1| serine/threonine protein phosphatase PP1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19113109|ref|NP_596317.1| serine/threonine protein phosphatase PP1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|130697|sp|P13681.1|PP11_SCHPO RecName: Full=Serine/threonine-protein phosphatase PP1-1 [NCBI NR]
  • gi|1204254|gb|AAA89197.1| protein phosphatase type 1 [Schizosaccharomyces pombe] [NCBI NR]
  • pir||A32550 phosphoprotein phosphatase (EC 3.1.3.16) dis2 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • serine/threonine protein phosphatase PP1 [Sanger Pombe]
  • Serine/threonine-protein phosphatase PP1-1 OS=Schizosaccharomyces pombe GN=dis2 PE=1 SV=1 [Swiss-Prot]
  • SERINE-THREONINE PROTEIN PHOSPHATASE PP1-1; SIMILAR TO S. CEREVISIAE GLC7: P13681; [pompepVF.fasta]
  • SERINE-THREONINE PROTEIN PHOSPHATASE PP1-1: P13681; [pompepV13]
  • Serine/threonine protein phosphatase PP1-1 (EC 3.1.3.16) [pompep4896]
  • |dis2|sds1, bws1|serine/threonine protein phosphatase pp1-1 [pompepnew.fasta]
  • |dis2|sds1, bws1|PP1|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • |dis2|sds1, bws1|serine/threonine protein phosphatase PP1|Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • serine-threonine protein phosphatase pp1-1 [Schizosaccharomyces pombe]gi|4176519|emb|CAA22875.1| dis2 [Schizosaccharomyces pombe]gi|130697|sp|P13681|PP11_SCHPO Serine/threonine protein phosphatase PP1-1gi|1204254|gb|AAA89197.1| protein phosphatase type [nrdb_11152004_Chlamydomonas]
  • (P13681) Serine/threonine protein phosphatase PP1-1 (EC 3.1.3.16) [pompep4896_normal_reversed]
  • SPBC776.02c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • protein phosphatase 1 [nr-271106-contam.fasta]
  • protein phosphatase type 1 [nr-271106-contam.fasta]
  • Serine/threonine-protein phosphatase PP1-1 [nr-271106-contam.fasta]
  • hypothetical protein SPBC776.02c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Serine/threonine-protein phosphatase PP1-1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dis2 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mRNA cleavage and polyadenylation specificity factor complex [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: DNA damage checkpoint [IGILink to PubMed article]
    regulation of homologous chromosome segregation [IMPLink to PubMed article]
    protein amino acid dephosphorylation [IDALink to PubMed article]
    regulation of mitotic sister chromatid segregation [IMPLink to PubMed article]
    microtubule cytoskeleton organization [IGILink to PubMed article]
    rRNA processing [ISS]
    regulation of mitotic cell cycle [IGILink to PubMed article]
    Molecular Function: phosphoprotein phosphatase activity [IDALink to PubMed article]
    iron ion binding [IEA]
    manganese ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNPDVDLDS IIDRLLEVRG SRPGRQVQLS EDEIRFLCNK AREIFISQPI LLELEAPLKI  60
   61 CGDIHGQYYD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL EVICLLLAYK IKYPENFFIL 120
  121 RGNHECASIN RIYGFYDECK RRYNIKLWKT FTDCFNCLPI AAIIDEKIFT MHGGLSPDLN 180
  181 SMDQIQRIMR PTDVPDTGLL CDLLWSDPDK DLTGWGDNDR GVSFTFGPDV VSRFLHKHDM 240
  241 DLVCRAHQVV EDGYEFFSKR QLVTLFSAPN YCGEFDNAGA MMSVDESLLC SFQILKPAEK 300
  301 KQRYGYQGSS QNWHMTPPRK NKTGNSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..327] PSI-BLAST 121.0 Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.126411744957937 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle