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Protein Overview: SPCC1259.09c

General Information:
Name(s) found: SPCC1259.09c [Sanger Pombe]
Description(s) found:
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  • pir||T40898 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase component [similarity] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|4049542|emb|CAA22547.1| pyruvate dehydrogenase protein x component [Schizosaccharomyces pombe] [NCBI NR]
  • gi|30913151|sp|O94709.1|ODPX_SCHPO RecName: Full=Probable pyruvate dehydrogenase protein X component, mitochondrial; AltName: Full=Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; Flags: Precursor [NCBI NR]
  • gi|19075565|ref|NP_588065.1| pyruvate dehydrogenase protein x component [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • pyruvate dehydrogenase protein x component [Sanger Pombe]
  • Probable pyruvate dehydrogenase protein X component, mitochondrial OS=Schizosaccharomyces pombe GN=SPCC1259.09c PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE PYRUVATE DEHYDROGENASE E2 SUBUNIT: O94709; [pompepVF.fasta]
  • Putative pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) [pompep4896]
  • |||putative pyruvate dehydrogenase E2 subunit [pompepnew.fasta]
  • |||pyruvate dehydrogenase protein x component (predicted)|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • putative pyruvate dehydrogenase E2 subunit [Schizosaccharomyces pombe]gi|4049542|emb|CAA22547.1| SPCC1259.09c [Schizosaccharomyces pombe]gi|30913151|sp|O94709|ODPX_SCHPO Putative pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihyd [nrdb_11152004_Chlamydomonas]
  • |||pyruvate dehydrogenase protein x component|Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • (O94709) Putative pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) [pompep4896_normal_reversed]
  • SPCC1259.09c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPCC1259.09c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • |pdx1||pyruvate dehydrogenase protein x component, Pdx1 |Schizosaccharomyces pombe|chr 3|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • Probable pyruvate dehydrogenase protein X component, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC1259.09c PE=2 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 456 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial pyruvate dehydrogenase complex [ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: acetyl-CoA biosynthetic process from pyruvate [ISSLink to PubMed article]
    Molecular Function: lipoic acid binding [NASLink to PubMed article]
    acyltransferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKHYIHQCV KASSCKHSLS VKQRYFHCSA LNGVASMFRM PALSPTMEEG NITKWHFKEG  60
   61 DSFKSGDILL EVETDKATMD VEVQDNGILA KVLIEKGSNI PVGKNIAIVA DAEDNLKDLE 120
  121 LPKDEASSEE QSFSSSKEEV KPIVQDRETK SNVEHKSTSQ ANDAVNKSFL PSVSYLIHQY 180
  181 KIENPWSIPA TGPHGRLLKG DVLAHVGKID KGVPSSLQKF VRNLEVLDFS GVEPKKPSYT 240
  241 EDSVPVRKST MIETLKTVPM KDEYITFERS ISLEKLKSLL AKRKEKDAFG IDEVVSAMIG 300
  301 DALSISELSK VEPNSIESAY DLLLGAPIVK LKSSVSNFQP KLFPKNNNTK DLHKYIRDSM 360
  361 IGLPSNLSDY VKLNFSSVTK SSSNNVEFLD DVYDMLLGSN SDSIDSRINR HEEPSTTEDL 420
  421 TLTLSIKDNI SKSRAIKFVD CLKSNFENPE FVLSRW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] PSI-BLAST 23.522879 The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
    2 View Details [221..456] PSI-BLAST 63.30103 Dihydrolipoamide succinyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  9.65061123545754 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  9.64995677986911 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  9.49696044977584 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  8.45313874919036 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  8.17557182322815 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  6.40483178382327 bayes_pls_golite062009
  • acetyltransferase activity
    		•  6.08159176722072 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.93985773477717 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  5.74314131636952 bayes_pls_golite062009
  • acyltransferase activity
    		•  5.72047003788767 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.60481199262496 bayes_pls_golite062009
  • S-succinyltransferase activity
    		•  4.10308166636667 bayes_pls_golite062009
  • dihydrolipoyllysine-residue succinyltransferase activity
    		•  4.10308166636667 bayes_pls_golite062009
  • carnitine O-acyltransferase activity
    		•  2.87366177129153 bayes_pls_golite062009
  • succinyltransferase activity
    		•  2.08404693277798 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  1.78431187655869 bayes_pls_golite062009
  • catalytic activity
    		•  1.51562638409295 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  1.33852311685118 bayes_pls_golite062009
  • O-palmitoyltransferase activity
    		•  1.22729402619659 bayes_pls_golite062009
  • carnitine O-palmitoyltransferase activity
    		•  1.22729402619659 bayes_pls_golite062009
  • transferase activity
    		•  1.08341671157927 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  1.00868366840715 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  0.1424856707148 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle