YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC1259.09c
Organism:	Schizosaccharomyces pombe
Length:	456 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC1259.09c.

Description	E-value	Query Range	Subject Range
gi\|22776771, gi\|... - gi\|23098545\|ref\|NP_692011.1\| dihydrolipoamide acetyltransferase [Oceanobacillus iheyensis HTE831], g...	355.0	[0..37]	[454..3]
gi\|52786003, gi\|... - gi\|52786003\|ref\|YP_091832.1\| dihydrolipoamide acetyltransferase [Bacillus licheniformis ATCC 14580],...	351.0	[0..37]	[454..3]
gi\|15614768, gi\|... - gi\|15614768\|ref\|NP_243071.1\| dihydrolipoamide acetyltransferase [Bacillus halodurans C-125], gi\|1017... gi\|25286430 - pir\|\|E83925 dihydrolipoamide succinyltransferase BH2205 [imported] - Bacillus halodurans (strain C-1...	350.0	[0..36]	[454..2]
gi\|56963878, gi\|... - gi\|56963878\|ref\|YP_175609.1\| dihydrolipoamide acetyltransferase [Bacillus clausii KSM-K16], gi\|56910...	350.0	[0..36]	[454..2]
gi\|162458262, gi... - gi\|5669871\|gb\|AAD46491.1\|AF135014_1 dihydrolipoamide S-acetyltransferase [Zea mays], gi\|162458262\|re...	348.0	[0..21]	[454..102]
gi\|33354212, gi\|... - gi\|50936281\|ref\|XP_477668.1\| unknown protein [Oryza sativa (japonica cultivar-group)], gi\|50510197\|d...	347.0	[0..31]	[454..114]
gi\|156192928, gi... - gi\|218529904\|ref\|YP_002420720.1\| 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyl... gi\|22652789 - gi\|22652789\|gb\|AAN03816.1\|AF497852_2 dihydrolipoamide succinyltransferase [Methylobacterium extorque... gi\|240008177, gi... - gi\|240138208\|ref\|YP_002962680.1\| dihydrolipoamide succinyltransferase component of 2-oxoglutarate de...	346.0	[0..34]	[454..1]
gi\|126096730, gi... - gi\|126207938\|ref\|YP_001053163.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog... gi\|32034768 - gi\|32034768\|ref\|ZP_00134893.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|189914931, gi... - gi\|190149800\|ref\|YP_001968325.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog...	343.0	[0..34]	[454..1]
ODO2_BACSU - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... gi\|16078996, gi\|... - gi\|2634329\|emb\|CAB13828.1\| 2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, ...	343.0	[0..37]	[454..3]

Back

Predicted Domain #1

Region A:
Residues: [1-220]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKHYIHQCV KASSCKHSLS VKQRYFHCSA LNGVASMFRM PALSPTMEEG NITKWHFKEG  60
   61 DSFKSGDILL EVETDKATMD VEVQDNGILA KVLIEKGSNI PVGKNIAIVA DAEDNLKDLE 120
  121 LPKDEASSEE QSFSSSKEEV KPIVQDRETK SNVEHKSTSQ ANDAVNKSFL PSVSYLIHQY 180
  181 KIENPWSIPA TGPHGRLLKG DVLAHVGKID KGVPSSLQKF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.522879
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [221-456]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRNLEVLDFS GVEPKKPSYT EDSVPVRKST MIETLKTVPM KDEYITFERS ISLEKLKSLL  60
   61 AKRKEKDAFG IDEVVSAMIG DALSISELSK VEPNSIESAY DLLLGAPIVK LKSSVSNFQP 120
  121 KLFPKNNNTK DLHKYIRDSM IGLPSNLSDY VKLNFSSVTK SSSNNVEFLD DVYDMLLGSN 180
  181 SDSIDSRINR HEEPSTTEDL TLTLSIKDNI SKSRAIKFVD CLKSNFENPE FVLSRW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.30103
Match:	1c4tA
Description:	Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	5.74314131636952	bayes_pls_golite062009
acyltransferase activity	5.72047003788767	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
S-succinyltransferase activity	4.10308166636667	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	4.10308166636667	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
succinyltransferase activity	2.08404693277798	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.78431187655869	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
O-acetyltransferase activity	0.1424856707148	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: