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Protein Overview: mkh1

General Information:
Name(s) found: mkh1 / SPAC1F3.02c [Sanger Pombe]
Description(s) found:
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  • pir||T38073 serine/threonine-protein kinase mhk1 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19113917|ref|NP_593005.1| MEK kinase (MEKK) Mkh1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|1708621|sp|Q10407.1|MKH1_SCHPO RecName: Full=MAP kinase kinase kinase mkh1 [NCBI NR]
  • gi|1280443|gb|AAB62319.1| Mkh1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1256513|emb|CAA94620.1| MEK kinase (MEKK) Mkh1 [Schizosaccharomyces pombe] [NCBI NR]
  • MEK kinase (MEKK) Mkh1 [Sanger Pombe]
  • MAP kinase kinase kinase mkh1 OS=Schizosaccharomyces pombe GN=mkh1 PE=2 SV=1 [Swiss-Prot]
  • MAPKK KINASE; INVOLVED IN CELL WALL MAINTENANCE; INVOLVED IN CHLORIDE HOMEOSTASIS: ;N0ACC; [pompepVF.fasta]
  • MAPKK KINASE MHK; INVOLVED IN CELL WALL MAINTENANCE INVOLVED IN CHLORIDE HOMEOSTASIS: ;N0ACC; [pompepV13]
  • MAP kinase kinase kinase mkh1 (EC 2.7.1.-) [pompep4896]
  • |mkh1||MEK kinase (PMID 9199286) [pompepnew.fasta]
  • |mkh1||MEK kinase (PMID 9199286)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • serine/threonine-protein kinase mhk1 [Schizosaccharomyces pombe]gi|1256513|emb|CAA94620.1| SPAC1F3.02c [Schizosaccharomyces pombe]gi|1708621|sp|Q10407|MKH1_SCHPO MAP kinase kinase kinase mkh1gi|7493394|pir||T38073 serine/threonine-protein kinase mhk1 - [nrdb_11152004_Chlamydomonas]
  • |mkh1||MEK kinase |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q10407) MAP kinase kinase kinase mkh1 (EC 2.7.1.-) [pompep4896_normal_reversed]
  • hypothetical protein SPAC1F3.02c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Mkh1 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • SPAC1F3.02c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • MAP kinase kinase kinase mkh1 [nr-271106-contam.fasta]
  • MAP kinase kinase kinase mkh1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mkh1 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1116 amino acids

    Gene Ontology:
    Cellular Component: cell septum [IDALink to PubMed article]
    cell division site [IDALink to PubMed article]
    cell tip [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: positive regulation of calcium-mediated signaling [IMPLink to PubMed article]
    MAPKKK cascade [IDALink to PubMed article]
    cellular response to heat [IMPLink to PubMed article]
    endoplasmic reticulum unfolded protein response [ISS]
    cell morphogenesis [NASLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    response to osmotic stress [IMPLink to PubMed article]
    cellular sodium ion homeostasis [NASLink to PubMed article]
    cytokinesis [NASLink to PubMed article]
    protein amino acid phosphorylation [ISSLink to PubMed article]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    protein binding [IPILink to PubMed article]
    MAP kinase kinase kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAADIGSQSS GSLEERFEQS LHLQNVDKQD WSLNSVLQFL KLYKFNKEWE DVFIKSRIEM  60
   61 DLFINLADQS KAEEFAFKNK LSKESAIQLS SCIRKTLLAP SSTRVPSKNS SYETLTYSAK 120
  121 DSSDDVFTET NSGFRSSNQN SSLKSFQSVP DSNVNVFGGF GGSVVDNNEL LSTGKNSHQT 180
  181 TSLNLEGSPI NLHAYKGTVT SIINDDSRNI NKKTLSKQPV SEHKEKQTSF LRRFRVPGFS 240
  241 RDKDKTKDCP SSNSNPFHLA SSNVKTLDAS LDQGEWVPRI HRLESQIGLI SKKKSFVLAT 300
  301 MDDMKFTVVD ITNVQNATQL RKLIAKSMYL DISIDQFDLF LTEVGGAQYI EILDDRKLDI 360
  361 ARLYSDEFGT IKFFVKPSQN EESGMDSDTY LSFGTKSSST YKADDDSIYH RKEDFKKQPS 420
  421 YPVLTSDFEI TDAGPNLSLS GHQPDNKYYK GFSSAPNLAV VPELPSRRFR GFEKIRGAKG 480
  481 EMATKILDAT EAQSEKNKFT VCRPHKKVTL KMPLNSGSSA PQSPSSNTSA SVLTRNFVAH 540
  541 RDPPPPPTET SSLRRKNTLT RRPSIRHARS SPYIDTGHNE ASKFSHTSFD PKASSKSSNS 600
  601 LKESVEALSE IPFEDAPALD ESDLSGDPFW AIQPKQSSSQ VPKENHHNIQ SKLSINTEAA 660
  661 TDLKANELSS PKTPEYCRGD DRSISLSPLS YRLRKSKHIR ESPPSSKVIN SGNWEVRPSA 720
  721 DDLYEDVDRF FPRYDLDKVL VVDQSRMVSS PSKVSIRPKM KSVRLLAREA SEARKEIRHN 780
  781 ARRNKSGNLL RRSSTKLWGS RIVELKPDTT ITSGSVVSQN ATFKWMKGEL IGNGTYGKVF 840
  841 LAMNINTGEL IAVKQVEIPQ TINGRHDQLR KDIVDSINAE ISMIADLDHL NIVQYLGFEK 900
  901 TETDISIFLE YVSGGSIGRC LRNYGPFEEQ LVRFVSRQVL YGLSYLHSKG IIHRDLKADN 960
  961 LLIDFDGVCK ISDFGISKHS DNVYDNDANL SMQGSIFWMA PEVIHNDHQG YSAKVDVWSL1020
 1021 GCVVLEMLAG RRPWSTDEAI QAMFKLGTEK KAPPIPSELV SQVSPEAIQF LNACFTVNAD1080
 1081 VRPTAEELLN HPFMKCDEEF NFKDTNLYDM LCKRKS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..84] FFAS03 1.17 Sterile alpha motif (SAM) domain of mouse bifunctional apoptosis regulator
    2 View Details [85..181] deduced N/A No confident structure predictions are available.
    3 View Details [182..272] MSA 3.151996 View MSA. No confident structure predictions are available.
    4 View Details [273..450] deduced N/A No confident structure predictions are available.
    5 View Details [451..596] deduced N/A No confident structure predictions are available.
    6 View Details [597..817] deduced N/A No confident structure predictions are available.
    7 View Details [818..1116] PSI-BLAST 64.30103 No description for 2clqA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle