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Protein Overview: pfk1

General Information:
Name(s) found: pfk1 / SPBC16H5.02 [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • 6-phosphofructokinase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 942 amino acids

    Gene Ontology:
    Cellular Component: 6-phosphofructokinase complex [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article][ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: glycolysis [ICLink to PubMed article][ISS]
    carbohydrate phosphorylation [IC]
    Molecular Function: magnesium ion binding [IEA]
    ATP binding [IDALink to PubMed article]
    fructose-6-phosphate binding [IDALink to PubMed article]
    6-phosphofructokinase activity [ICLink to PubMed article][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGETVHGIS CYSVVANTED TYNQTLDFYQ KLGFKKVASF GTSDSDNARV CNESLREDWM  60
   61 HVAGNNSAES VTIKFRLVPG ELSLSPAAED SEWRGQKSSL VFYYPNLLDL LKQLSADAIK 120
  121 YQAFPNEKKP DEVYVEDPLG NLIGFSDRYN PFAHANLKKS EESGAASNLE SGLATPVVET 180
  181 LKKATTSDKP AGVKKKIAVM TSGGDSPGMN AVVRAVARIA IHRGCDAFAI YEGYEGLVQG 240
  241 GDMIKQLQWG DVRGWLAEGG TLIGTARCMA FRERPGRLRA AKNLISAGID SIIVCGGDGS 300
  301 LTGADIFRSD WPGLVKELED TKAITPEQAK LYRHLTIVGL VGSIDNDMSS TDVTIGAFSS 360
  361 LHRICEAVDS ISSTAISHSR AFIVEVMGRH CGWLAVLAAL ATGADFVFIP ERPAEVGKWQ 420
  421 DELCNSLSSV RKLGKRKSIV IVAEGAIDSE LNHISPEDIK NLLVERLHLD TRVTTLGHVQ 480
  481 RGGIPCAYDR MLATLQGVDA VDAVLASTPD TPSPMIAING NKINRKPLME AVKLTHEVAD 540
  541 AIEKKQFAHA MELRDPEFAD YLHTWEGTTF IEDESHFVPK DERMRVAIIH VGAPAGGMNS 600
  601 ATRAAVRYCL NRGHTPLAID NGFSGFLRHD SIHELSWIDV DEWCIRGGSE IGTNRDTPDL 660
  661 DMGFTAFKFQ QHKIDALIII GGFEAFTALS QLESARVNYP SFRIPMAIIP ATISNNVPGT 720
  721 EFSLGCDTCL NAVMEYCDTI KQSASASRRR VFVCEVQGGR SGYIATVGGL ITGASAIYTP 780
  781 EDGISLDMLR KDIDHLKATF ALEAGRNRAG QLILRNECAS KVYTTEVIGN IISEEAHKRF 840
  841 SARTAVPGHV QQGGNPTPMD RARAARLAMR AIRFFETCRA NDLGNDPSSA VVIGIRGTGV 900
  901 SFSSVADVEN NETEIEMRRP KNAWWRDMHN LVNILAGKTF AD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run dam1 No Comments Liu X, et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] FFAS03 2.5 Crystal Structure of the Glyoxalase Family Protein APC24694 from Bacillus cereus
    2 View Details [191..560] PSI-BLAST 111.0 PHOSPHOFRUCTOKINASE. STRUCTURE AND CONTROL
    3 View Details [561..942] PSI-BLAST 76.39794 No description for 2higA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.35877948593853 bayes_pls_golite062009
  • binding
    		•  1.28817277275486 bayes_pls_golite062009
  • catalytic activity
    		•  1.13770612627414 bayes_pls_golite062009
    2
    Term Confidence Notes
  • 6-phosphofructokinase activity
    		•  12.7403693686468 bayes_pls_golite062009
  • phosphofructokinase activity
    		•  11.7059647240147 bayes_pls_golite062009
  • fructose-6-phosphate binding
    		•  9.55959144901554 bayes_pls_golite062009
  • fructose binding
    		•  9.55841643584799 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  9.54757838113048 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  3.19280659830412 bayes_pls_golite062009
  • kinase activity
    		•  2.85624705588769 bayes_pls_golite062009
  • fructose-2,6-bisphosphate 2-phosphatase activity
    		•  2.7198911999025 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.67472251964197 bayes_pls_golite062009
  • sugar binding
    		•  2.21212411210899 bayes_pls_golite062009
  • monosaccharide binding
    		•  2.05358532613083 bayes_pls_golite062009
  • transferase activity
    		•  1.97789134877808 bayes_pls_golite062009
  • catalytic activity
    		•  1.89212073381079 bayes_pls_golite062009
  • protein binding
    		•  1.76136621968843 bayes_pls_golite062009
  • binding
    		•  1.57437723650762 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.97067862054315 bayes_pls_golite062009
  • hydrolase activity
    		•  0.276140444059183 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.184982121995695 bayes_pls_golite062009
  • tubulin binding
    		•  0.0889554716245424 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle