YRC Public Data Repository - Protein Structure Prediction

Protein:	pfk1
Organism:	Schizosaccharomyces pombe
Length:	942 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pfk1.

Description	E-value	Query Range	Subject Range
PFKA1_PICPA - ATP-dependent 6-phosphofructokinase subunit alpha OS=Komagataella pastoris GN=PFK1 PE=1 SV=1	967.0	[0..1]	[938..1]
PFKA_YARLI - ATP-dependent 6-phosphofructokinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PFK1 PE=2 SV... K6P1_YARLI, K6PF... - 6-phosphofructokinase subunit alpha OS=Yarrowia lipolytica GN=PFK1 PE=2 SV=2, (P59680) 6-phosphofruc...	965.0	[0..6]	[939..2]
PFK2 - Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaero... PFKA2_YEAST - ATP-dependent 6-phosphofructokinase subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S...	950.0	[0..4]	[942..6]
PFKA1_CANAX - ATP-dependent 6-phosphofructokinase subunit alpha OS=Candida albicans GN=PFK1 PE=1 SV=1 gi\|238882854 - gi\|238882854\|gb\|EEQ46492.1\| 6-phosphofructokinase alpha subunit [Candida albicans WO-1]	946.0	[0..2]	[941..4]
orf19.11449, orf... - PFK1 CGDID:CAL0003055 Assembly 19, Contig19-10194 (123809, 126772) CDS, translated using codon table... gi\|68468074, gi\|... - gi\|68468074\|ref\|XP_721876.1\| phosphofructokinase alpha subunit [Candida albicans SC5314], gi\|6846775...	946.0	[0..2]	[941..4]
K6P1_KLULA, K6PF... - 6-phosphofructokinase subunit alpha OS=Kluyveromyces lactis GN=PFK1 PE=1 SV=1, (Q03215) 6-phosphofru... PFKA1_KLULA - ATP-dependent 6-phosphofructokinase subunit alpha OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 23...	925.0	[0..5]	[941..4]

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Predicted Domain #1

Region A:
Residues: [1-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGETVHGIS CYSVVANTED TYNQTLDFYQ KLGFKKVASF GTSDSDNARV CNESLREDWM  60
   61 HVAGNNSAES VTIKFRLVPG ELSLSPAAED SEWRGQKSSL VFYYPNLLDL LKQLSADAIK 120
  121 YQAFPNEKKP DEVYVEDPLG NLIGFSDRYN PFAHANLKKS EESGAASNLE SGLATPVVET 180
  181 LKKATTSDKP

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.5
Match:	1ss4A
Description:	Crystal Structure of the Glyoxalase Family Protein APC24694 from Bacillus cereus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	1.35877948593853	bayes_pls_golite062009
binding	1.28817277275486	bayes_pls_golite062009
catalytic activity	1.13770612627414	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [191-560]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGVKKKIAVM TSGGDSPGMN AVVRAVARIA IHRGCDAFAI YEGYEGLVQG GDMIKQLQWG  60
   61 DVRGWLAEGG TLIGTARCMA FRERPGRLRA AKNLISAGID SIIVCGGDGS LTGADIFRSD 120
  121 WPGLVKELED TKAITPEQAK LYRHLTIVGL VGSIDNDMSS TDVTIGAFSS LHRICEAVDS 180
  181 ISSTAISHSR AFIVEVMGRH CGWLAVLAAL ATGADFVFIP ERPAEVGKWQ DELCNSLSSV 240
  241 RKLGKRKSIV IVAEGAIDSE LNHISPEDIK NLLVERLHLD TRVTTLGHVQ RGGIPCAYDR 300
  301 MLATLQGVDA VDAVLASTPD TPSPMIAING NKINRKPLME AVKLTHEVAD AIEKKQFAHA 360
  361 MELRDPEFAD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	111.0
Match:	3pfkA
Description:	PHOSPHOFRUCTOKINASE. STRUCTURE AND CONTROL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
6-phosphofructokinase activity	12.7403693686468	bayes_pls_golite062009
phosphofructokinase activity	11.7059647240147	bayes_pls_golite062009
fructose-6-phosphate binding	9.55959144901554	bayes_pls_golite062009
fructose binding	9.55841643584799	bayes_pls_golite062009
carbohydrate kinase activity	9.54757838113048	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	3.19280659830412	bayes_pls_golite062009
kinase activity	2.85624705588769	bayes_pls_golite062009
fructose-2,6-bisphosphate 2-phosphatase activity	2.7198911999025	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.67472251964197	bayes_pls_golite062009
sugar binding	2.21212411210899	bayes_pls_golite062009
monosaccharide binding	2.05358532613083	bayes_pls_golite062009
transferase activity	1.97789134877808	bayes_pls_golite062009
catalytic activity	1.89212073381079	bayes_pls_golite062009
protein binding	1.76136621968843	bayes_pls_golite062009
binding	1.57437723650762	bayes_pls_golite062009
carbohydrate binding	0.97067862054315	bayes_pls_golite062009
hydrolase activity	0.276140444059183	bayes_pls_golite062009
cytoskeletal protein binding	0.184982121995695	bayes_pls_golite062009
tubulin binding	0.0889554716245424	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [561-942]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YLHTWEGTTF IEDESHFVPK DERMRVAIIH VGAPAGGMNS ATRAAVRYCL NRGHTPLAID  60
   61 NGFSGFLRHD SIHELSWIDV DEWCIRGGSE IGTNRDTPDL DMGFTAFKFQ QHKIDALIII 120
  121 GGFEAFTALS QLESARVNYP SFRIPMAIIP ATISNNVPGT EFSLGCDTCL NAVMEYCDTI 180
  181 KQSASASRRR VFVCEVQGGR SGYIATVGGL ITGASAIYTP EDGISLDMLR KDIDHLKATF 240
  241 ALEAGRNRAG QLILRNECAS KVYTTEVIGN IISEEAHKRF SARTAVPGHV QQGGNPTPMD 300
  301 RARAARLAMR AIRFFETCRA NDLGNDPSSA VVIGIRGTGV SFSSVADVEN NETEIEMRRP 360
  361 KNAWWRDMHN LVNILAGKTF AD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.39794
Match:	2higA
Description:	No description for 2higA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: