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Protein Overview: tif45

General Information:
Name(s) found: tif45 / SPAC16E8.15 [Sanger Pombe]
Description(s) found:
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  • gi|2494317|sp|P78954.1|IF4E1_SCHPO RecName: Full=Eukaryotic translation initiation factor 4E-1; Short=eIF-4E-1; Short=eIF4E-1; AltName: Full=mRNA cap-binding protein 1; AltName: Full=eIF-4F 25 kDa subunit 1 [NCBI NR]
  • gi|2330703|emb|CAB11043.1| translation initiation factor eIF4E, 4F complex subunit [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115140|ref|NP_594228.1| translation initiation factor eIF4E, 4F complex subunit [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1771713|emb|CAA67807.1| eIF4E protein [Schizosaccharomyces pombe] [NCBI NR]
  • pir||T43287 translation initiation factor eIF-4E [similarity] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • translation initiation factor eIF4E, 4F complex subunit [Sanger Pombe]
  • (P78954) Eukaryotic translation initiation factor 4E-1 (eIF4E-1) (eIF-4E-1) (mRNA cap-binding protein 1) (eIF-4F 25 kDa subunit 1) [Swiss-Prot]
  • Eukaryotic translation initiation factor 4E-1 OS=Schizosaccharomyces pombe GN=tif451 PE=2 SV=1 [Swiss-Prot]
  • EUKARYOTIC TRANSLATION INITIATION FACTOR 4E: P78954; [pompepVF.fasta]
  • Eukaryotic translation initiation factor 4E-1 (eIF4E-1) (eIF-4E-1) (mRNA cap-binding protein 1) (eIF-4F 25 kDa subunit 1) [pompep4896]
  • |tif45|tif1|eukaryotic translation initiation factor 4e (PMID 8955119) [pompepnew.fasta]
  • |tif45|tif1|translation initiation factor|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • eukaryotic translation initiation factor 4e [Schizosaccharomyces pombe]gi|1771713|emb|CAA67807.1| eIF4E protein [Schizosaccharomyces pombe]gi|2330703|emb|CAB11043.1| translation initiation factor; eIF4E (subunit) (PMID 8955119); eIF4G-binding (PMID 1171 [nrdb_11152004_Chlamydomonas]
  • |tif45|tif1|translation initiation factor eIF4E, 4F complex subunit|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC16E8.15 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • eIF4E protein [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC16E8.15 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Eukaryotic translation initiation factor 4E-1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tif451 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 218 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    eukaryotic translation initiation factor 4F complex [TASLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: positive regulation of translational initiation [ICLink to PubMed article]
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [ISSLink to PubMed article]
    translational initiation [TASLink to PubMed article]
    Molecular Function: translation initiation factor activity [ISSLink to PubMed article]
    RNA cap binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTEQPPKES QTENTVSEPQ EKALRTVFDD KINFNLKHPL ARPWTLWFLM PPTPGLEWNE  60
   61 LQKNIITFNS VEEFWGIHNN INPASSLPIK SDYSFFREGV RPEWEDVHNK TGGKWAFQNK 120
  121 GRGGNALDEM WLTTVLAAIG ETLDPTGQEV MGVVINMRKG FYRLAVWTKS CNNREVLMEI 180
  181 GTRFKQVLNL PRSETIEFSA HEDSSKSGST RAKTRMSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..218] PSI-BLAST 77.30103 Translation initiation factor eIF4e

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • translation initiation factor activity
    		•  12.6022960879923 bayes_pls_golite062009
  • RNA cap binding
    		•  8.70938037002519 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  7.91586572659635 bayes_pls_golite062009
  • translation regulator activity
    		•  7.87578736455963 bayes_pls_golite062009
  • RNA binding
    		•  6.31187636707846 bayes_pls_golite062009
  • binding
    		•  3.48071223822752 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.46353214508261 bayes_pls_golite062009
  • protein binding
    		•  0.850113401405075 bayes_pls_golite062009
  • RNA 7-methylguanosine cap binding
    		•  0.544036568660606 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle