YRC Public Data Repository - Protein Structure Prediction

Protein:	tif45
Organism:	Schizosaccharomyces pombe
Length:	218 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tif45.

Description	E-value	Query Range	Subject Range
gi\|50746789 - gi\|50746789\|ref\|XP_420655.1\| PREDICTED: similar to eIF-4E [Gallus gallus]	298.0	[0..8]	[218..54]
gi\|94370433 - gi\|94370433\|ref\|XP_930840.2\| PREDICTED: similar to eIF-4E [Mus musculus]	288.0	[0..18]	[218..17]
gi\|67969074 - gi\|67969074\|dbj\|BAE00892.1\| unnamed protein product [Macaca fascicularis]	288.0	[0..22]	[218..44]
IF4E_MOUSE - Eukaryotic translation initiation factor 4E OS=Mus musculus GN=Eif4e PE=1 SV=1 IF4E_RAT - Eukaryotic translation initiation factor 4E OS=Rattus norvegicus GN=Eif4e PE=1 SV=1	287.0	[0..18]	[218..17]
IF4E_BOVIN - (Q9N0T5) Eukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNA cap-binding protein)	286.0	[0..22]	[218..21]
IF4E_RABIT - Eukaryotic translation initiation factor 4E OS=Oryctolagus cuniculus GN=EIF4E PE=1 SV=1	286.0	[0..22]	[218..21]
gi\|60830630 - gi\|60830630\|gb\|AAX36938.1\| eukaryotic translation initiation factor 4E [synthetic construct]	286.0	[0..22]	[218..21]
gi\|74001995 - gi\|74001995\|ref\|XP_544992.2\| PREDICTED: similar to Eukaryotic translation initiation factor 4E (eIF4...	285.0	[0..22]	[218..21]
EIF4E - eukaryotic translation initiation factor 4E gi\|60819169, gi\|... - gi\|61363092\|gb\|AAX42333.1\| eukaryotic translation initiation factor 4E [synthetic construct], gi\|608... gi\|90078144 - gi\|90078144\|dbj\|BAE88752.1\| unnamed protein product [Macaca fascicularis] ENSPTRT00000030331 - null HGNC:3287\|MIM:13... - translation initiation factor 4E gi\|109075052 - gi\|109075052\|ref\|XP_001104976.1\| PREDICTED: similar to Eukaryotic translation initiation factor 4E (...	285.0	[0..22]	[218..21]
gi\|147904808, gi... - gi\|7443509\|pir\|\|S69004 translation initiation factor eIF-4E, long splice form - African clawed frog,...	285.0	[0..2]	[218..13]

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Predicted Domain #1

Region A:
Residues: [1-218]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQTEQPPKES QTENTVSEPQ EKALRTVFDD KINFNLKHPL ARPWTLWFLM PPTPGLEWNE  60
   61 LQKNIITFNS VEEFWGIHNN INPASSLPIK SDYSFFREGV RPEWEDVHNK TGGKWAFQNK 120
  121 GRGGNALDEM WLTTVLAAIG ETLDPTGQEV MGVVINMRKG FYRLAVWTKS CNNREVLMEI 180
  181 GTRFKQVLNL PRSETIEFSA HEDSSKSGST RAKTRMSV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.30103
Match:	1ipbA
Description:	Translation initiation factor eIF4e
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	12.6022960879923	bayes_pls_golite062009
RNA cap binding	8.70938037002519	bayes_pls_golite062009
translation factor activity, nucleic acid binding	7.91586572659635	bayes_pls_golite062009
translation regulator activity	7.87578736455963	bayes_pls_golite062009
RNA binding	6.31187636707846	bayes_pls_golite062009
binding	3.48071223822752	bayes_pls_golite062009
nucleic acid binding	3.46353214508261	bayes_pls_golite062009
protein binding	0.850113401405075	bayes_pls_golite062009
RNA 7-methylguanosine cap binding	0.544036568660606	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: