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Protein Overview: hus1

General Information:
Name(s) found: hus1 / SPAC20G4.04c [Sanger Pombe]
Description(s) found:
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  • gi|3219811|sp|P78955.1|HUS1_SCHPO RecName: Full=Checkpoint protein hus1 [NCBI NR]
  • gi|2330760|emb|CAB11254.1| checkpoint clamp complex protein Hus1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115651|ref|NP_594739.1| checkpoint clamp complex protein Hus1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|1730487|emb|CAA70588.1| hus1+ [Schizosaccharomyces pombe] [NCBI NR]
  • pir||T43396 mitotic and DNA damage checkpoint protein hus1 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • checkpoint clamp complex protein Hus1 [Sanger Pombe]
  • Checkpoint protein hus1 OS=Schizosaccharomyces pombe GN=hus1 PE=1 SV=1 [Swiss-Prot]
  • HUS1 PROTEIN; DNA DAMAGE CHECKPOINT PROTEIN; SIMILAR TO S. CEREVISIAE MEC3: P78955; [pompepVF.fasta]
  • HUS1 PROTEIN; DNA DAMAGE CHECKPOINT; HOMOLOGUE OF S. CEREVISIAE MEC3: P78955; [pompepV13]
  • Protein hus1 [pompep4896]
  • |hus1||PCNA related protein [pompepnew.fasta]
  • |hus1||PCNA related protein|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • |hus1||checkpoint clamp complex protein|Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • hus1 protein [Schizosaccharomyces pombe]gi|1730487|emb|CAA70588.1| hus1+ [Schizosaccharomyces pombe]gi|2330760|emb|CAB11254.1| hus1 [Schizosaccharomyces pombe]gi|3219811|sp|P78955|HUS1_SCHPO Protein hus1gi|11280797|pir||T43396 mitotic and DNA damage c [nrdb_11152004_Chlamydomonas]
  • (P78955) Protein hus1 [pompep4896_normal_reversed]
  • |hus1||checkpoint clamp complex protein Hus1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hus1+ [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Checkpoint protein hus1 [nr-271106-contam.fasta]
  • SPAC20G4.04c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC20G4.04c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Checkpoint protein hus1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hus1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 287 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    checkpoint clamp complex [IDALink to PubMed article]
    Biological Process: DNA damage checkpoint [TASLink to PubMed article]
    DNA replication checkpoint [TASLink to PubMed article]
    S-M checkpoint [IMPLink to PubMed article]
    intra-S DNA damage checkpoint [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed articleLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFKTRISNL YTLTRLVQAL DKIGRFCWLR LMPETVNFVI VPDFRMTQVW SVLEVETIFE  60
   61 DYVVQSNADN VINLEVPIDN FYKALRSAAN ASDSTVRLSK KNNQPLLSLS TTWSGRAFGS 120
  121 NIVTHNIPVR VLSQSYVSVI KEPTAPEPDC HIFLPQLNFL RHVVDKYKSL SDRIIMSANM 180
  181 SGELQLSVNI PSARVSTKWK GLENPELDPS QVEDISRHPS QTRAPEEFVH MRLDSKDLVN 240
  241 MLKISSVAKR VIACFCEGHA LVLYVYITDP EDEHTAVLTY YISTYVD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..287] PSI-BLAST 79.522879 Prolifirating cell nuclear antigen (PCNA)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  5.01426276108174 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.9656505576274 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.36414326788613 bayes_pls_golite062009
  • DNA polymerase processivity factor activity
    		•  3.26999202934887 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  3.23598180825386 bayes_pls_golite062009
  • transferase activity
    		•  2.5167471642449 bayes_pls_golite062009
  • DNA binding
    		•  2.06316167255592 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.02054974752473 bayes_pls_golite062009
  • binding
    		•  1.88302251910664 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.785542777582287 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.552326589459571 bayes_pls_golite062009
  • catalytic activity
    		•  0.48077242755678 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.457118392479642 bayes_pls_golite062009
  • protein binding
    		•  0.452894757163315 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  0.366820812506101 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle