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Protein Overview: gcs1

General Information:
Name(s) found: gcs1 / SPAC22F3.10c [Sanger Pombe]
Description(s) found:
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  • pir||T38181 glutamate-cysteine ligase (EC 6.3.2.2) - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19113943|ref|NP_593031.1| glutamate-cysteine ligase Gcs1 (PMID 8619315) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1170035|sp|Q09768.1|GSH1_SCHPO RecName: Full=Glutamate--cysteine ligase; AltName: Full=Gamma-glutamylcysteine synthetase; AltName: Full=Gamma-ECS; Short=GCS [NCBI NR]
  • gi|1008438|emb|CAA91075.1| glutamate-cysteine ligase Gcs1 [Schizosaccharomyces pombe] [NCBI NR]
  • glutamate-cysteine ligase Gcs1 [Sanger Pombe]
  • Glutamate--cysteine ligase OS=Schizosaccharomyces pombe GN=gcs1 PE=2 SV=1 [Swiss-Prot]
  • GLUTAMATE--CYSTEINE LIGASE: Q09768; [pompepVF.fasta]
  • Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) [pompep4896]
  • |gcs1||glutamate--cysteine ligase (PMID 8619315) [pompepnew.fasta]
  • |gcs1||glutamate--cysteine ligase (PMID 8619315)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • glutamate--cysteine ligase [Schizosaccharomyces pombe]gi|1008438|emb|CAA91075.1| gcs1 [Schizosaccharomyces pombe]gi|1170035|sp|Q09768|GSH1_SCHPO Glutamate--cysteine ligase (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS)gi|7490586|pir||T38181 glut [nrdb_11152004_Chlamydomonas]
  • |gcs1||glutamate--cysteine ligase |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q09768) Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) [pompep4896_normal_reversed]
  • |gcs1|apd1|glutamate-cysteine ligase Gcs1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC22F3.10c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Glutamate--cysteine ligase (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) [nr-271106-contam.fasta]
  • hypothetical protein SPAC22F3.10c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Glutamate--cysteine ligase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gcs1 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 669 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    glutamate-cysteine ligase complex [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: glutathione biosynthetic process [IMPLink to PubMed article]
    response to cadmium ion [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    glutamate-cysteine ligase activity [IMPLink to PubMed article]
    metal chelating activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLVLGTPL DWPESKKYCD YVRENGIMQF LHMYDTYISK KQDVLLWGDE IECIVVSMDD  60
   61 KSKKARVSLR QEDILNALGK YEETFRHVDF GPVYAALRNE TCPKKIDAIL SEVAKNPADY 120
  121 VERIGGNSNK DTIEITSSTK PHAQNAVPTF HPEYGRYMLE STPGAPYGST LKDFTFVEYN 180
  181 MRLRRKIIEN HLLPNELPLT ITNFFRLGTP GFTDPEVEAN GAISRSFFLP DDVINTHVRF 240
  241 PTLTANIRQR RGRKVAMNVP IFFDKNTIKP FHDPTVPWDR NLFPEDANAR DGAALDNHIY 300
  301 MDSMGFGMGC CCLQITFQAK SCDEARLLYD QLTPITPLML ALSAGTPAFR GYLADQDCRW 360
  361 NVIAGAVDDR TEEEMKTVPK SRYDSVDLYI SNDKRNLPEY NDVPVVINQD CYDKLIKDCI 420
  421 DERLAKHMAH IFSRDPLVIF SDSILQDNSV SNAHFENLNS TNWQSMRFKP PPPGSDIGWR 480
  481 VEFRSMEIQI TDFENAAYSI FVVMLSRAIL SFNLNLYMPI SLVDENMKAA HARDAIHRKK 540
  541 FWFRCNPFPD ASTDDESGQF RQLTIDELFN GEHRENGFPG LITIVRSYLY SCNPDAKTIC 600
  601 LIERYIRLIS QRANGQCLTA ASWIRNFITT HPSYKQDSVV NDEINYDLIR RIAKIVDGDY 660
  661 DDTLLGKCS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..669] FFAS03 1.64 No description for 2gwcA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle