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Protein Overview: shm2

General Information:
Name(s) found: shm2 / SPAC18G6.04c [Sanger Pombe]
Description(s) found:
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  • pir||T37918 serine hydroxymethyltransferase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19114580|ref|NP_593668.1| serine hydroxymethyltransferase Shm2 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1346154|sp|Q10104.1|GLYC_SCHPO RecName: Full=Probable serine hydroxymethyltransferase, cytosolic; Short=SHMT; Short=Serine methylase; AltName: Full=Glycine hydroxymethyltransferase [NCBI NR]
  • gi|1122369|emb|CAA92384.1| serine hydroxymethyltransferase Shm2 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • serine hydroxymethyltransferase Shm2 [Sanger Pombe]
  • Probable serine hydroxymethyltransferase, cytosolic OS=Schizosaccharomyces pombe GN=shm2 PE=2 SV=1 [Swiss-Prot]
  • SERINE HYDROXYMETHYLTRANSFERASE: Q10104; [pompepVF.fasta]
  • Probable serine hydroxymethyltransferase, cytosolic (EC 2.1.2.1) (Serine methylase) (Glycine hydroxymethyltransferase) (SHMT) [pompep4896]
  • |shm2||serine hydroxymethyltransferase [pompepnew.fasta]
  • |shm2||serine hydroxymethyltransferase (predicted)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • serine hydroxymethyltransferase [Schizosaccharomyces pombe]gi|1122369|emb|CAA92384.1| shm2 [Schizosaccharomyces pombe]gi|7493372|pir||T37918 serine hydroxymethyltransferase - fission yeast (Schizosaccharomyces pombe)gi|1346154|sp|Q10104|GLYC_SCHPO Pro [nrdb_11152004_Chlamydomonas]
  • |shm2||serine hydroxymethyltransferase|Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q10104) Probable serine hydroxymethyltransferase, cytosolic (EC 2.1.2.1) (Serine methylase) (Glycine hydroxymethyltransferase) (SHMT) [pompep4896_normal_reversed]
  • |shm2||serine hydroxymethyltransferase Shm2 |Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Probable serine hydroxymethyltransferase, cytosolic (Serine methylase) (Glycine hydroxymethyltransferase) (SHMT) [nr-271106-contam.fasta]
  • SPAC18G6.04c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC18G6.04c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
    • Organism: Schizosaccharomyces pombe
    Length: 472 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: L-serine metabolic process [IEA]
    serine family amino acid biosynthetic process [ISSLink to PubMed article]
    one-carbon metabolic process [ICLink to PubMed article]
    glycine metabolic process [ISSLink to PubMed article]
    Molecular Function: pyridoxal phosphate binding [IEA]
    glycine hydroxymethyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKCSNKVLTI IKLLKAPLAE CDPTVYKILE SEKSRQKESI ALIASENFTS RAVMDALGSI  60
   61 MQNKYSEGYP GARYYGGNEF IDQAERLCQT RALEAFHLDG EKWGVNVQPH SGSPANLQAY 120
  121 QAVMKPHDRL MGLDLPHGGH LSHGFSTPQK AISAVSTYFS TMPYNVNKET GIIDYDSLEK 180
  181 AAIQFRPKVI VAGASAYARL VDYKRMRKIT EMCNAYLLCD MAHISGLVAA GVIPSPFEYA 240
  241 DIVTTTTHKS LRGPRGAMIF YRKGTRSHDK RGNPILYELE DKINFSVFPG HQGGPHNHTI 300
  301 TALAVALGQA KTPEFYQYQK DVLSNAKAMA NAFITRGYKL VSGGTDTHLV LVDLTDKGVD 360
  361 GARVERILEL VNISANKNTV PGDKSALIPR GLRLGTPACT TRGFDEKDFE RVVELIDEVV 420
  421 SLTKKINEAA LKEGKSKFRD FKAYVGDGSK FSEIAKLKKE VITWAGKFDF PV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..472] PSI-BLAST 90.522879 Human mitochondrial serine hydroxymethyltransferase 2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  3.359406422625 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  3.2128372762799 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  3.2128372762799 bayes_pls_golite062009
  • transferase activity
    		•  2.59075614411581 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  2.47911083054773 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • O-phospho-L-serine:2-oxoglutarate aminotransferase activity
    		•  2.1692959843619 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.67701710033155 bayes_pls_golite062009
  • DNA binding
    		•  1.4774443071095 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39741122443159 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.19150094103499 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15775909410582 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  1.14675852378654 bayes_pls_golite062009
  • binding
    		•  1.09053123792737 bayes_pls_golite062009
  • structural molecule activity
    		•  0.754675308623467 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.681623261233707 bayes_pls_golite062009
  • vitamin binding
    		•  0.66463470119531 bayes_pls_golite062009
  • protein binding
    		•  0.613130945854863 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.60304280865376 bayes_pls_golite062009
  • L-allo-threonine aldolase activity
    		•  0.500744432308415 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.271623203801431 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle