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Protein Overview: SPBC1709.17

General Information:
Name(s) found: SPBC1709.17 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • folylpolyglutamate synthase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 505 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: glutamate metabolic process [RCALink to PubMed article]
    folic acid and derivative biosynthetic process [ISSLink to PubMed article]
    cellular amino acid metabolic process [RCALink to PubMed article]
    one-carbon metabolic process [ISSLink to PubMed article]
    Molecular Function: tetrahydrofolylpolyglutamate synthase activity [ISSLink to PubMed article]
    ATP binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHTAKPVKRY FNLKSSRIGM NPQTKTFEGA INRLNSLQSN AKVLEVLRKR GKIPNDQSMV  60
   61 EMRHWLRCIG YQPSDLNRLN VIHVAGTKGK GSTCAFTSSI LQQIQKSGER SIPKCIGMYT 120
  121 SPHLRSVCER IQLNGKPISQ ELFTKYFFDV WERLENAVGS DSEKPMYFRF LTLMAWHVFI 180
  181 SENVDAAIIE VGIGGEYDST NLIEKPYATA VTSLGLDHTS LLGNTIAEIA WQKAGIYKES 240
  241 AIALTCEQAP EAMNVLKNRA AERNTSLKVV IPPAELTPDM IGLSGVHQLG NTSLAVSLVQ 300
  301 EFYEKAGCPF DRDPYQDPAI LDGLKYVKWP GRCQIEEINN IKWCFDGAHT KESLEATGLW 360
  361 LASKKNLYED ADARILLFNQ QSRDDPIALL RSFLKGLESS GTGISFTHVI FSTNVTWKDA 420
  421 GYNPELLSIN TITDNKPVLH VQEDLCKWWK ESKGTTSEAT VAPTIQEAIE TVMSIKQKSR 480
  481 NTFVCVTGSL HLTGGVFVVL DQAVF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..505] PSI-BLAST 62.045757 Crystal structure of Folylpolyglutamate synthase (TM0166) from Thermotoga maritima at 2.10 A resolution

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acid-amino acid ligase activity
    		•  4.37731070676891 bayes_pls_golite062009
  • tetrahydrofolylpolyglutamate synthase activity
    		•  3.94486215528378 bayes_pls_golite062009
  • ligase activity
    		•  3.80574681739772 bayes_pls_golite062009
  • catalytic activity
    		•  2.66037860982128 bayes_pls_golite062009
  • dihydrofolate synthase activity
    		•  2.50201834836027 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.96801058335544 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle