YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC1709.17
Organism:	Schizosaccharomyces pombe
Length:	505 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC1709.17.

Description	E-value	Query Range	Subject Range
gi\|34849806, gi\|... - gi\|47087409\|ref\|NP_998602.1\| folylpolyglutamate synthase [Danio rerio], gi\|34849806\|gb\|AAH58343.1\| F...	284.0	[0..2]	[504..22]
FPGS - folylpolyglutamate synthase	279.0	[0..22]	[504..40]
gi\|149039000, gi... - gi\|226342937\|ref\|NP_001139597.2\| folylpolyglutamate synthase [Rattus norvegicus], gi\|149039000\|gb\|ED...	274.0	[0..22]	[504..40]
gi\|90300411, gi\|... - gi\|90300411\|gb\|EAS30042.1\| folylpolyglutamate synthase [Coccidioides immitis RS], gi\|119180272\|ref\|X...	272.0	[0..25]	[501..30]
gi\|74152384 - gi\|74152384\|dbj\|BAE33941.1\| unnamed protein product [Mus musculus]	272.0	[0..22]	[504..40]
gi\|14582587 - gi\|14582587\|gb\|AAK69546.1\|AF283647_1 folylpoly-gammaglutamate synthetase precursor [Cricetulus grise...	272.0	[0..22]	[504..40]

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Predicted Domain #1

Region A:
Residues: [1-505]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHTAKPVKRY FNLKSSRIGM NPQTKTFEGA INRLNSLQSN AKVLEVLRKR GKIPNDQSMV  60
   61 EMRHWLRCIG YQPSDLNRLN VIHVAGTKGK GSTCAFTSSI LQQIQKSGER SIPKCIGMYT 120
  121 SPHLRSVCER IQLNGKPISQ ELFTKYFFDV WERLENAVGS DSEKPMYFRF LTLMAWHVFI 180
  181 SENVDAAIIE VGIGGEYDST NLIEKPYATA VTSLGLDHTS LLGNTIAEIA WQKAGIYKES 240
  241 AIALTCEQAP EAMNVLKNRA AERNTSLKVV IPPAELTPDM IGLSGVHQLG NTSLAVSLVQ 300
  301 EFYEKAGCPF DRDPYQDPAI LDGLKYVKWP GRCQIEEINN IKWCFDGAHT KESLEATGLW 360
  361 LASKKNLYED ADARILLFNQ QSRDDPIALL RSFLKGLESS GTGISFTHVI FSTNVTWKDA 420
  421 GYNPELLSIN TITDNKPVLH VQEDLCKWWK ESKGTTSEAT VAPTIQEAIE TVMSIKQKSR 480
  481 NTFVCVTGSL HLTGGVFVVL DQAVF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.045757
Match:	1o5zA
Description:	Crystal structure of Folylpolyglutamate synthase (TM0166) from Thermotoga maritima at 2.10 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acid-amino acid ligase activity	4.37731070676891	bayes_pls_golite062009
tetrahydrofolylpolyglutamate synthase activity	3.94486215528378	bayes_pls_golite062009
ligase activity	3.80574681739772	bayes_pls_golite062009
catalytic activity	2.66037860982128	bayes_pls_golite062009
dihydrofolate synthase activity	2.50201834836027	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	1.96801058335544	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: