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Protein Overview: tif224

General Information:
Name(s) found: tif224 / SPAC21E11.06 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • translation initiation factor eIF2B delta subunit [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 467 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    eukaryotic translation initiation factor 2B complex [ISSLink to PubMed article]
    Biological Process: positive regulation of translational initiation [ICLink to PubMed article]
    translational initiation [ISSLink to PubMed article]
    Molecular Function: translation initiation factor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFSAEQAKK DGKDQSPVSE SSSVGGTSPA TASSVVSPNE PKLSGKEAKA LKKARKQASR  60
   61 RAKAEAAAAN NPPGVSEEKK VAIPNKNSNQ QKKASKQNPQ NSPETDANLQ EKKIFEEKQV 120
  121 SIFSHLDWRR RRTTENIPKD IHPAVIRLGL KLANYKIFGS NQRCIDLLKT FKIVIQDYQT 180
  181 PYGTTLSRHL TTHINSQIAY LVSTRPLSIS MGNAIRFLKL EISVLDIDLT DDEGKELLLE 240
  241 KIDSYIRDRI IIAGQVIVQA ATEKIQDGDV ILTYLHSSTV NDVLIHAKNV GKKFRVVVVD 300
  301 SRPEFEGRVC LKLLTEHGIE CTYVMISALS YIMQEVTKIF LGGHAMLSNG ALYSRAGTSL 360
  361 ISLLGHESNV PVIACCESYK FTERIQLDSL VYNELAPGDQ LVNMGVDDFE EKPGVLANWK 420
  421 SVKNLKLLSL KYDVTPPRLI TVCVCEMGLL PSTSVPAIIN EFKQVYA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] PSI-BLAST 18.522879 No description for 1y0fB was found.
    2 View Details [129..467] PSI-BLAST 87.522879 X-ray crystal structure of aIF-2B alpha subunit-related translation initiation factor [Thermotoga maritima]

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • translation initiation factor activity
    		•  10.1099993541596 bayes_pls_golite062009
  • translation regulator activity
    		•  5.74669335554405 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.17718456512191 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.9283980201455 bayes_pls_golite062009
  • DNA binding
    		•  1.55389679363348 bayes_pls_golite062009
  • binding
    		•  1.53908996868286 bayes_pls_golite062009
  • catalytic activity
    		•  1.31732715713197 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.09424756417577 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.03828732072006 bayes_pls_golite062009
  • transcription factor activity
    		•  0.995059566132783 bayes_pls_golite062009
  • sugar binding
    		•  0.319281682893106 bayes_pls_golite062009
  • protein binding
    		•  0.0293610121675921 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle