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View Structure Prediction Details

Protein: tif224
Organism: Schizosaccharomyces pombe
Length: 467 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tif224.

Description E-value Query
Range
Subject
Range
EI2BD_RAT - Translation initiation factor eIF-2B subunit delta OS=Rattus norvegicus GN=Eif2b4 PE=2 SV=1
332.0 [0..12] [460..55]
gi|114576632 - gi|114576632|ref|XP_001157413.1| PREDICTED: eukaryotic translation initiation factor 2B, subunit 4 d...
328.0 [0..9] [460..40]
gi|33337571 - gi|33337571|gb|AAQ13438.1|AF057699_1 EIF-2B-delta-like protein [Homo sapiens]
327.0 [0..9] [460..53]
gi|471329, gi|13... - gi|471329|emb|CAA53204.1| translation initiation factor eIF-2B-delta [Oryctolagus cuniculus], gi|130...
326.0 [0..12] [460..59]
gi|73979950 - gi|73979950|ref|XP_532909.2| PREDICTED: similar to eukaryotic translation initiation factor 2B, subu...
326.0 [0..13] [460..78]

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Predicted Domain #1
Region A:
Residues: [1-128]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGFSAEQAKK DGKDQSPVSE SSSVGGTSPA TASSVVSPNE PKLSGKEAKA LKKARKQASR  60
   61 RAKAEAAAAN NPPGVSEEKK VAIPNKNSNQ QKKASKQNPQ NSPETDANLQ EKKIFEEKQV 120
  121 SIFSHLDW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.522879
Match: 1y0fB
Description: No description for 1y0fB was found.

Predicted Domain #2
Region A:
Residues: [129-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRRRTTENIP KDIHPAVIRL GLKLANYKIF GSNQRCIDLL KTFKIVIQDY QTPYGTTLSR  60
   61 HLTTHINSQI AYLVSTRPLS ISMGNAIRFL KLEISVLDID LTDDEGKELL LEKIDSYIRD 120
  121 RIIIAGQVIV QAATEKIQDG DVILTYLHSS TVNDVLIHAK NVGKKFRVVV VDSRPEFEGR 180
  181 VCLKLLTEHG IECTYVMISA LSYIMQEVTK IFLGGHAMLS NGALYSRAGT SLISLLGHES 240
  241 NVPVIACCES YKFTERIQLD SLVYNELAPG DQLVNMGVDD FEEKPGVLAN WKSVKNLKLL 300
  301 SLKYDVTPPR LITVCVCEMG LLPSTSVPAI INEFKQVYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.522879
Match: 1t9kA
Description: X-ray crystal structure of aIF-2B alpha subunit-related translation initiation factor [Thermotoga maritima]
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 10.1099993541596 bayes_pls_golite062009
translation regulator activity 5.74669335554405 bayes_pls_golite062009
nucleic acid binding 2.17718456512191 bayes_pls_golite062009
transcription regulator activity 1.9283980201455 bayes_pls_golite062009
DNA binding 1.55389679363348 bayes_pls_golite062009
binding 1.53908996868286 bayes_pls_golite062009
catalytic activity 1.31732715713197 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.09424756417577 bayes_pls_golite062009
transcription repressor activity 1.03828732072006 bayes_pls_golite062009
transcription factor activity 0.995059566132783 bayes_pls_golite062009
sugar binding 0.319281682893106 bayes_pls_golite062009
protein binding 0.0293610121675921 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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