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Protein Overview: dis1

General Information:
Name(s) found: dis1 / SPCC736.14 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • microtubule-associated protein Dis1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 882 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    microtubule cytoskeleton [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed articleLink to PubMed article]
    spindle [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [TASLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: sister chromatid segregation [IMPLink to PubMed article]
    spindle assembly [TASLink to PubMed article]
    attachment of spindle microtubules to kinetochore [IDALink to PubMed article]
    microtubule-based process [ICLink to PubMed article]
    Molecular Function: microtubule binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELDDFNSRI LSQIFDKSWK VRFEAYESLL HALNRALDDS DVCFQPWIHD PALWKQGLCD  60
   61 SNVPTQEHAV KSLRCFLDKS RQKGVNSAKS FVVAPLLEKC LPSPRQSIRD ASHQALLILA 120
  121 KSDALDYVLE GLFSAARVKH PKQAVASIKE LNSLLENFGI PALSPIPFYK LIPTLFAQSD 180
  181 KNIRQEASNL SITLYAWVGN AFKTHVFPQL KQIQVSDLEA SFQNVTSRTT TGGHISNSLN 240
  241 TQEVVLPSFS SNAKPKPHLS SKSSSQGNTL QRSTSSFSTP NRKVSQPSDF SASPSRSIVS 300
  301 PAKNIVGSTP VDVLSKLTPE FHTALSSPKW KDRKEALESM VPVCSNPVYQ EGDYSELLRV 360
  361 IAKSLKDANV VVVGVAALLL THIAKALRKG FLPYTGIVLP SLFDRFKERK SSLVHSLLDA 420
  421 ANAIFESCGL NDIMDETLEF LKHKNPQVKT ETLRWLNRCL QLTDVCPPRA SLETLCSLCV 480
  481 TLINDTFEPV RMATTNVLAT LVQIFSQPVL SKYIVGLDPK KLPKILELSK DITVNAHPNQ 540
  541 PSRPRLPRVA SPLKTSPVKL AVTPQAPSPL PSSNPSQASL TEESLSTRSS PTKPSTTSLR 600
  601 SQSLVNRFAS STLKAPSSSS KGVSNAASSK QSFPSSPSIS KKLETSRLST KKLPGSTMKA 660
  661 ASALKEYPQQ QSMKSGGEKQ DNLVTITMSE KVELDLLREE KAIRQVQEAE DALERERLFR 720
  721 EINDLQIQNA EMKEQVYEKE STISQKEVEI TSLRNEKDRL STRLQQVLLE LEKQHETNEE 780
  781 AMDIDLKVPE SGAIGRVTTR ATATTAMDES GNAGMVSSGI HSVSTKPSSY GTRRSLAGSM 840
  841 LQKPTQFSRP SFMFSPEARD NWRESHDLSS HLWEQIQRMK KA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..394] PSI-BLAST 24.30103 Adaptin beta subunit N-terminal fragment
    2 View Details [395..468] PSI-BLAST 5.39794 No description for 2iw3A was found.
    3 View Details [469..542] PSI-BLAST 31.221849 No description for 2qk2A was found.
    4 View Details [543..882] FFAS03 1.86 No description for 2i1jA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  3.05338750264476 bayes_pls_golite062009
  • binding
    		•  2.86831493830281 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • actin binding
    		•  1.76244772281676 bayes_pls_golite062009
  • protein binding
    		•  1.63705839411934 bayes_pls_golite062009
  • transporter activity
    		•  1.55621630624352 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.33334123659384 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.15447282085461 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.804909841250605 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.350388174853674 bayes_pls_golite062009
  • signal sequence binding
    		•  0.27824906981293 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.141331164449492 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.123389318446902 bayes_pls_golite062009
  • DNA binding
    		•  0.089209424262799 bayes_pls_golite062009
  • RNA binding
    		•  0.0370585094254798 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle