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View Structure Prediction Details

Protein: dis1
Organism: Schizosaccharomyces pombe
Length: 882 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dis1.

Description E-value Query
Range
Subject
Range
CLASP1 - cytoplasmic linker associated protein 1
446.0 [0..7] [767..5]
gi|14599402 - gi|14599402|emb|CAC43454.1| probable microtubule associated protein [Pneumocystis carinii]
436.0 [0..1] [882..4]
gi|82881254, gi|... - gi|94363870|ref|XP_900513.2| PREDICTED: CLASP1 isoform 6 [Mus musculus], gi|82881254|ref|XP_927106.1...
434.0 [0..7] [692..5]
gi|76668544 - gi|76668544|ref|XP_601740.2| PREDICTED: similar to CLIP-associating protein 1 [Bos taurus]
429.0 [0..7] [767..5]
gi|109104489 - gi|109104489|ref|XP_001085566.1| PREDICTED: similar to CLIP-associating protein 1 [Macaca mulatta]
425.0 [0..7] [709..5]

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Predicted Domain #1
Region A:
Residues: [1-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELDDFNSRI LSQIFDKSWK VRFEAYESLL HALNRALDDS DVCFQPWIHD PALWKQGLCD  60
   61 SNVPTQEHAV KSLRCFLDKS RQKGVNSAKS FVVAPLLEKC LPSPRQSIRD ASHQALLILA 120
  121 KSDALDYVLE GLFSAARVKH PKQAVASIKE LNSLLENFGI PALSPIPFYK LIPTLFAQSD 180
  181 KNIRQEASNL SITLYAWVGN AFKTHVFPQL KQIQVSDLEA SFQNVTSRTT TGGHISNSLN 240
  241 TQEVVLPSFS SNAKPKPHLS SKSSSQGNTL QRSTSSFSTP NRKVSQPSDF SASPSRSIVS 300
  301 PAKNIVGSTP VDVLSKLTPE FHTALSSPKW KDRKEALESM VPVCSNPVYQ EGDYSELLRV 360
  361 IAKSLKDANV VVVGVAALLL THIAKALRKG FLPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.30103
Match: 1gw5B
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 3.05338750264476 bayes_pls_golite062009
binding 2.86831493830281 bayes_pls_golite062009
cytoskeletal protein binding 2.61566088685247 bayes_pls_golite062009
actin binding 1.76244772281676 bayes_pls_golite062009
protein binding 1.63705839411934 bayes_pls_golite062009
transporter activity 1.55621630624352 bayes_pls_golite062009
substrate-specific transporter activity 1.33334123659384 bayes_pls_golite062009
protein transmembrane transporter activity 1.15447282085461 bayes_pls_golite062009
nucleic acid binding 0.804909841250605 bayes_pls_golite062009
transmembrane transporter activity 0.350388174853674 bayes_pls_golite062009
signal sequence binding 0.27824906981293 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.141331164449492 bayes_pls_golite062009
transcription regulator activity 0.123389318446902 bayes_pls_golite062009
DNA binding 0.089209424262799 bayes_pls_golite062009
RNA binding 0.0370585094254798 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [395-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGIVLPSLFD RFKERKSSLV HSLLDAANAI FESCGLNDIM DETLEFLKHK NPQVKTETLR  60
   61 WLNRCLQLTD VCPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.39794
Match: 2iw3A
Description: No description for 2iw3A was found.

Predicted Domain #3
Region A:
Residues: [469-542]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RASLETLCSL CVTLINDTFE PVRMATTNVL ATLVQIFSQP VLSKYIVGLD PKKLPKILEL  60
   61 SKDITVNAHP NQPS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.221849
Match: 2qk2A
Description: No description for 2qk2A was found.

Predicted Domain #4
Region A:
Residues: [543-882]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPRLPRVASP LKTSPVKLAV TPQAPSPLPS SNPSQASLTE ESLSTRSSPT KPSTTSLRSQ  60
   61 SLVNRFASST LKAPSSSSKG VSNAASSKQS FPSSPSISKK LETSRLSTKK LPGSTMKAAS 120
  121 ALKEYPQQQS MKSGGEKQDN LVTITMSEKV ELDLLREEKA IRQVQEAEDA LERERLFREI 180
  181 NDLQIQNAEM KEQVYEKEST ISQKEVEITS LRNEKDRLST RLQQVLLELE KQHETNEEAM 240
  241 DIDLKVPESG AIGRVTTRAT ATTAMDESGN AGMVSSGIHS VSTKPSSYGT RRSLAGSMLQ 300
  301 KPTQFSRPSF MFSPEARDNW RESHDLSSHL WEQIQRMKKA 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.86
Match: 2i1jA
Description: No description for 2i1jA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle