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Protein Overview: clr3

General Information:
Name(s) found: clr3 / SPBC800.03 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • histone deacetylase (class II) Clr3 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 687 amino acids

    Gene Ontology:
    Cellular Component: mating-type region heterochromatin [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    nuclear chromatin [IDALink to PubMed article]
    telomeric heterochromatin [IDALink to PubMed article]
    NuRD complex [IDALink to PubMed article]
    histone deacetylase complex [NASLink to PubMed article]
    rDNA heterochromatin [IDALink to PubMed article]
    centromeric heterochromatin [IDALink to PubMed article]
    nucleolar chromatin [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    regulation of histone methylation [IMPLink to PubMed article]
    chromatin silencing at centromere [IMPLink to PubMed article]
    chromatin silencing at rDNA [IMPLink to PubMed article]
    nucleosome positioning [IMPLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    histone deacetylation [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IEPLink to PubMed article]
    Molecular Function: histone deacetylase activity [IDALink to PubMed article][IMPLink to PubMed article]
    histone deacetylase activity (H3-K14 specific) [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLASNSDGAS TSVKPSDDAV NTVTPWSILL TNNKPMSGSE NTLNNESHEM SQILKKSGLC  60
   61 YDPRMRFHAT LSEVDDHPED PRRVLRVFEA IKKAGYVSNV PSPSDVFLRI PAREATLEEL 120
  121 LQVHSQEMYD RVTNTEKMSH EDLANLEKIS DSLYYNNESA FCARLACGSA IETCTAVVTG 180
  181 QVKNAFAVVR PPGHHAEPHK PGGFCLFNNV SVTARSMLQR FPDKIKRVLI VDWDIHHGNG 240
  241 TQMAFYDDPN VLYVSLHRYE NGRFYPGTNY GCAENCGEGP GLGRTVNIPW SCAGMGDGDY 300
  301 IYAFQRVVMP VAYEFDPDLV IVSCGFDAAA GDHIGQFLLT PAAYAHMTQM LMGLADGKVF 360
  361 ISLEGGYNLD SISTSALAVA QSLLGIPPGR LHTTYACPQA VATINHVTKI QSQYWRCMRP 420
  421 KHFDANPKDA HVDRLHDVIR TYQAKKLFED WKITNMPILR DSVSNVFNNQ VLCSSNFFQK 480
  481 DNLLVIVHES PRVLGNGTSE TNVLNLNDSL LVDPVSLYVE WAMQQDWGLI DINIPEVVTD 540
  541 GENAPVDILS EVKELCLYVW DNYVELSISK NIFFIGGGKA VHGLVNLASS RNVSDRVKCM 600
  601 VNFLGTEPLV GLKTASEEDL PTWYYRHSLV FVSSSNECWK KAKRAKRRYG RLMQSEHTET 660
  661 SDMMEQHYRA VTQYLLHLLQ KARPTSQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..419] PSI-BLAST 103.0 No description for 2nvrA was found.
    2 View Details [420..687] FFAS03 1.12 No description for 2r8bA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • deacetylase activity
    		•  6.54075174712552 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.11117025144926 bayes_pls_golite062009
  • hydrolase activity
    		•  1.60018186789194 bayes_pls_golite062009
  • structural molecule activity
    		•  1.57651476285011 bayes_pls_golite062009
  • catalytic activity
    		•  1.2983708611085 bayes_pls_golite062009
  • binding
    		•  1.08169264016862 bayes_pls_golite062009
  • protein binding
    		•  0.954507778375691 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.936052349626823 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.856360387483181 bayes_pls_golite062009
  • acetyltransferase activity
    		•  0.807420416019793 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle