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Protein Overview: cek1

General Information:
Name(s) found: cek1 / SPCC1450.11c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • serine/threonine protein kinase Cek1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1338 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: signal transduction [IEA]
    protein amino acid phosphorylation [ICLink to PubMed article]
    regulation of mitotic cell cycle [IGILink to PubMed article]
    Molecular Function: ATP binding [IEA]
    protein serine/threonine kinase activity [TASLink to PubMed article]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKHIKNEREE VFLEDDQAQH SQAELLSSKD ENLQPSIPLS PVAFELDFSG NFQFISDNSS  60
   61 ELLDIPKDKI IGHSVAEVLG TDGYNAFMRA VNCLLKDDSH SYHVRFQHSI NANHANQNYY 120
  121 TAKGDLPSDE KITKPFDAIG ILIRHPGSAI PAHTMWVVNP ATNSLGSVSP LVTKLLDVIG 180
  181 FGASLLDKYL CDLRTSYHKH NSLDALPLPT PEFCQICERE IQSWFFELHS KFCLSTSTYE 240
  241 SVVQAAQDSL LYFRSTLLEI QEGMQKDSSL VPVYKNEPLI VDADDYFFTD ENKQTLSLCS 300
  301 FLSQVMYYLE VAIDITIPPV KIIVNFDKVD SLRVQSPRSE KATIELDNYN PSLENCSSAV 360
  361 IALWEDIKTA VDTKITGVLR LRNAIYYSER IRLEIDHHVQ EIIDDVVSNL VTNHSSTSLG 420
  421 HLESKLAPSI TFPDACDALE AEECITRPGS ATNTPQSDRS LDINDLSRSS SYSRHLSHVS 480
  481 LSNPDFAIGS PMSQDSSNYS SPLHRRKASD SNFSDPRFDD LKYLSPNSSP RFVASDGPNR 540
  541 PASNGRSSLF SRGRASNLGD VGLRLPSPSP RIHTIVPNSA PEHPSINDYK ILKPISKGAF 600
  601 GSVYLAQKRT TGDYFAIKIL KKSNMIAKNQ VINVRAERAI LMSQGESPFV AKLYYTFQSK 660
  661 DYLYLVMEYL NGGDCGSLLK TMGVLDLDWI RTYIAETVLC LGDLHDRGII HRDIKPENLL 720
  721 ISQNGHLKLT DFGLSRVGYM KRHRRKQSSS IPVLDLRDRS SAISDLSLST ASSVLEAQSL 780
  781 ITPERPKRPS LNEKLLSLDG TSIRLAGQSF NYENSAEDSP TATNTPTSQV DESNIFRSTD 840
  841 SPRVQPFFEN KDPSKRFIGT PDYIAPEVIL GNPGIKASDW WSLGCVVFEF LFGYPPFNAE 900
  901 TPDQVFQNIL ARRINWPAEV FTAESSVALD LIDRLLCMNP ANRLGANGVE EIKAHPFFKS 960
  961 VNWDTILEED PPFVPKPFSP EDTVYFDSRG LKGFDFSEYY NQPTVTEAQK LEEERPASSI1020
 1021 PQHVSGNRKG RLRSNTISTP EFGSFTYRNL DFLNKANRNT IQKLRKEHMA VKSAKTSVDD1080
 1081 TFSQYMSRFK AKLSTSQSVG PVKSSRRASM ADYEASTTTR VQDITTDSID SIDDFDSLKE1140
 1141 GRMLSFFDNL ALEDHKGVSS TMSASQSQSS MHTALPDVTE GTSSDEHTTI QKGRIDNLQA1200
 1201 QSLTHKRNAI SYPGLFQLDR LQMIIPKDEI ELAEILKKIF PKLTLVLIDD PWSILKKLLQ1260
 1261 NEQFNVVFLH FGNDKVSSSR LMYSVRTSAT INSRVPFVYI CEDETCIPTD LQSDGVLLKP1320
 1321 ITCENIESCL RKLDVWHS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..263] FFAS03 2.06 Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
    2 View Details [264..553] deduced N/A No confident structure predictions are available.
    3 View Details [554..850] PSI-BLAST 58.522879 The structure of the N-terminal kinase domain of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein
    4 View Details [851..916] PSI-BLAST 63.522879 cAMP-dependent PK, catalytic subunit
    5 View Details [917..1204] FFAS03 2.19 G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2
    6 View Details [1205..1338] PSI-BLAST 11.69897 No description for 2ayxA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.10874590528357 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.684204466593894 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.196560862858137 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.52256824388179 bayes_pls_golite062009
  • protein binding
    		•  1.95763087285706 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.55414958698765 bayes_pls_golite062009
  • kinase activity
    		•  1.52393509273639 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.39413069155432 bayes_pls_golite062009
  • transferase activity
    		•  1.09391396934652 bayes_pls_golite062009
  • protein kinase activity
    		•  1.07426739991648 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.62326150960884 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle