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Protein Overview: bub1

General Information:
Name(s) found: bub1 / SPCC1322.12c [Sanger Pombe]
Description(s) found:
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  • gi|4176552|emb|CAA22865.1| serine/threonine protein kinase Bub1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|4063611|gb|AAC98348.1| protein kinase Bub1p [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075640|ref|NP_588140.1| serine/threonine protein kinase Bub1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|12229696|sp|O94751.1|BUB1_SCHPO RecName: Full=Checkpoint serine/threonine-protein kinase bub1 [NCBI NR]
  • pir||T43800 protein kinase bub1, checkpoint-associated - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • serine/threonine protein kinase Bub1 [Sanger Pombe]
  • Checkpoint serine/threonine-protein kinase bub1 OS=Schizosaccharomyces pombe GN=bub1 PE=1 SV=1 [Swiss-Prot]
  • SPINDLE CHECKPOINT PROTEIN KINASE; ESSENTIAL; MITOTIC CENTROMERE PROTEIN; REQUIRED FOR PRESERVATION OF CORRECT PLOIDY THROUGH MITOSIS: O94751; [pompepVF.fasta]
  • Checkpoint serine/threonine-protein kinase bub1 (EC 2.7.1.-) [pompep4896]
  • |bub1||spindle assembly checkpoint component (PMID 9864354) [pompepnew.fasta]
  • Checkpoint serine/threonine-protein kinase bub1 (EC 2.7.1.37) [4896.FASTAC]
  • |bub1||serine/threonine protein kinase|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • |bub1||serine/threonine protein kinase Bub1|Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • protein kinase bub1p [Schizosaccharomyces pombe]gi|4176552|emb|CAA22865.1| bub1 [Schizosaccharomyces pombe]gi|12229696|sp|O94751|BUB1_SCHPO Checkpoint serine/threonine-protein kinase bub1gi|4063611|gb|AAC98348.1| protein kinase Bub1p [Schizosaccharomyc [nrdb_11152004_Chlamydomonas]
  • (O94751) Checkpoint serine/threonine-protein kinase bub1 (EC 2.7.1.-) [pompep4896_normal_reversed]
  • hypothetical protein SPCC1322.12c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPCC1322.12c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Checkpoint serine/threonine-protein kinase bub1 [nr-271106-contam.fasta]
  • protein kinase Bub1p [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Checkpoint serine/threonine-protein kinase bub1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=bub1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1044 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed article]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IMPLink to PubMed article]
    meiotic sister chromatid cohesion [IGILink to PubMed article]
    signal transduction [RCALink to PubMed article]
    attachment of spindle microtubules to kinetochore [IGILink to PubMed article]
    protein amino acid phosphorylation [IEA]
    cellular protein localization [IGILink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    protein binding [IPILink to PubMed article]
    protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDWRLTENV LDQNIPETKP RESKTRLEEI QRLALFQEEL DIIEELDDPV DVWYRCIEWL  60
   61 LETRFLGMET VNKMLDDAIQ YLERCRFALN DVRHLLIQLA KIKQSYETPD ELQQAAKQFY 120
  121 QLASKGIGLE LALFYEEYGS LLIRMQRWKE ASEVFHAAVS REARPLVRLL RNAAEFSRAY 180
  181 DLHNAHPSIH DAPYSSPFPP PRIVLGSKPV SSSTLPSKPK SFQVFSDASS SRDSQNASDL 240
  241 PQAKSLESEA NTPNLPLLYD KSSGKRVEYS AFNFLALYEN GEERSMEECR AQRYLSSIQP 300
  301 NTAASFPKVV PKNEISVHHD SSSSNVSPIY KNPVAEQSDT PTRSLPKNYA YVAKSTSPEL 360
  361 KVFDTVMPVA LSPKPAQKPP SPTIHTKAAL ADILDIFNQP LRSESLEKSS KSPISAQSSY 420
  421 LGTPLKNDEN SSNSGATSLT GRSQEEHLDF IPSLTPSKNY PSKIYSPNKN LDFSHTASKA 480
  481 ETYKNSNELE NVKREQPFSE LLPSTLQEET ATGTTSTTFA NAKRRPEDSN ISPTNPKKLH 540
  541 TLPRSPQYST VDSNSVLSPA MPKGYMFVNE NQSMKHESSV SNPVATIPHE NGKHDFGQLS 600
  601 PIEHKPFFPK NDDELPGPSG YLTMPYEEAM ASLSNLPTLI NPLDQSLRDL LFQVLRPSLL 660
  661 RDKDYHEHET SFALVEHIES FVSKIKPKAG GPGRRRSSNR HSLDGPEFHL FYPPNTNLSV 720
  721 ISKLGQGAFA PVYLVKSKIE TENGDVSQGG AENNESKLFA LKIETPPSCF EFYLTRQAMT 780
  781 RLKGLRETNS ILPVHQLHMF HDTSHLLMDY RPQGSILDLV NSMHNSTFSS SGMDEILVVF 840
  841 FSIEFLRIIE ALHTHKIIHG DLKADNALLR LETVADSEWS PIYSPEGLYG WSFKGIYLID 900
  901 FGRGIDLSLF EEKVKFIADW DTDLQDCIEM REGRPWTYQI DYHGLAAIIY TMLFGQYIET 960
  961 RIEVINGQRR QVLTQRMKRY WNQDLWHRLF DLLLNPTLHV SEENLPMTEE LSKIRIEMEE1020
 1021 WLVNHSTGGS GLKGLLKSIE KRKI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..239] FFAS03 1.53 No description for 2ooeA was found.
    2 View Details [240..388] deduced N/A No confident structure predictions are available.
    3 View Details [389..1044] PSI-BLAST 75.0 No description for 2h8hA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein kinase activity
    		•  2.56362090019902 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.1214292592052 bayes_pls_golite062009
  • kinase activity
    		•  1.87389866531382 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.85529180726136 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.66424140461588 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.1208666000428 bayes_pls_golite062009
  • telethonin binding
    		•  0.880108382130672 bayes_pls_golite062009
  • transferase activity
    		•  0.876865688160088 bayes_pls_golite062009
  • ATP binding
    		•  0.5817701531934 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.546494897702862 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.539760789902549 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.511706857793891 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.511646852033539 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.511126133432142 bayes_pls_golite062009
  • nucleotide binding
    		•  0.503624561336457 bayes_pls_golite062009
  • molecular adaptor activity
    		•  0.494024302340603 bayes_pls_golite062009
  • tubulin binding
    		•  0.488928950975855 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.476542772435059 bayes_pls_golite062009
  • actin binding
    		•  0.464111806616899 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  0.409062479526042 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.370788151516215 bayes_pls_golite062009
  • microtubule binding
    		•  0.196718452862042 bayes_pls_golite062009
  • transporter activity
    		•  0.187543377461637 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.0413380592707298 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.00586886096202299 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle