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View Structure Prediction Details

Protein: bub1
Organism: Schizosaccharomyces pombe
Length: 1044 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for bub1.

Description E-value Query
Range		 Subject
Range
gi|7513785, gi|2... - gi|7513785|pir||T31004 probable mitotic checkpoint control protein kinase BUB1 - mouse (fragment), g...
 382.0 [0..32] [1043..54]
gi|157817678, gi... - gi|62645833|ref|XP_215849.3| PREDICTED: similar to budding uninhibited by benzimidazoles 1 homolog [...
 358.0 [0..32] [1036..10]
gi|475128 - gi|475128|gb|AAA64894.1| protein kinase [Saccharomyces cerevisiae]
 353.0 [0..12] [1042..16]
gi|61368242 - gi|61368242|gb|AAX43137.1| BUB1 budding uninhibited by benzimidazoles 1-like beta [synthetic constru...
 352.0 [0..9] [997..39]

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Predicted Domain #1
Region A:
Residues: [1-239] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDWRLTENV LDQNIPETKP RESKTRLEEI QRLALFQEEL DIIEELDDPV DVWYRCIEWL  60
   61 LETRFLGMET VNKMLDDAIQ YLERCRFALN DVRHLLIQLA KIKQSYETPD ELQQAAKQFY 120
  121 QLASKGIGLE LALFYEEYGS LLIRMQRWKE ASEVFHAAVS REARPLVRLL RNAAEFSRAY 180
  181 DLHNAHPSIH DAPYSSPFPP PRIVLGSKPV SSSTLPSKPK SFQVFSDASS SRDSQNASD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.53
Match: 2ooeA
Description: No description for 2ooeA was found.

Predicted Domain #2
Region A:
Residues: [240-388] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPQAKSLESE ANTPNLPLLY DKSSGKRVEY SAFNFLALYE NGEERSMEEC RAQRYLSSIQ  60
   61 PNTAASFPKV VPKNEISVHH DSSSSNVSPI YKNPVAEQSD TPTRSLPKNY AYVAKSTSPE 120
  121 LKVFDTVMPV ALSPKPAQKP PSPTIHTKA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [389-1044] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALADILDIFN QPLRSESLEK SSKSPISAQS SYLGTPLKND ENSSNSGATS LTGRSQEEHL  60
   61 DFIPSLTPSK NYPSKIYSPN KNLDFSHTAS KAETYKNSNE LENVKREQPF SELLPSTLQE 120
  121 ETATGTTSTT FANAKRRPED SNISPTNPKK LHTLPRSPQY STVDSNSVLS PAMPKGYMFV 180
  181 NENQSMKHES SVSNPVATIP HENGKHDFGQ LSPIEHKPFF PKNDDELPGP SGYLTMPYEE 240
  241 AMASLSNLPT LINPLDQSLR DLLFQVLRPS LLRDKDYHEH ETSFALVEHI ESFVSKIKPK 300
  301 AGGPGRRRSS NRHSLDGPEF HLFYPPNTNL SVISKLGQGA FAPVYLVKSK IETENGDVSQ 360
  361 GGAENNESKL FALKIETPPS CFEFYLTRQA MTRLKGLRET NSILPVHQLH MFHDTSHLLM 420
  421 DYRPQGSILD LVNSMHNSTF SSSGMDEILV VFFSIEFLRI IEALHTHKII HGDLKADNAL 480
  481 LRLETVADSE WSPIYSPEGL YGWSFKGIYL IDFGRGIDLS LFEEKVKFIA DWDTDLQDCI 540
  541 EMREGRPWTY QIDYHGLAAI IYTMLFGQYI ETRIEVINGQ RRQVLTQRMK RYWNQDLWHR 600
  601 LFDLLLNPTL HVSEENLPMT EELSKIRIEM EEWLVNHSTG GSGLKGLLKS IEKRKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.0
Match: 2h8hA
Description: No description for 2h8hA was found.

Predicted functions:

Term Confidence Notes
binding 2.74863538127007 bayes_pls_golite062009
protein kinase activity 2.56362090019902 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.1214292592052 bayes_pls_golite062009
kinase activity 1.87389866531382 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.85529180726136 bayes_pls_golite062009
protein serine/threonine kinase activity 1.66424140461588 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
cytoskeletal protein binding 1.1208666000428 bayes_pls_golite062009
telethonin binding 0.880108382130672 bayes_pls_golite062009
transferase activity 0.876865688160088 bayes_pls_golite062009
ATP binding 0.5817701531934 bayes_pls_golite062009
adenyl ribonucleotide binding 0.546494897702862 bayes_pls_golite062009
adenyl nucleotide binding 0.539760789902549 bayes_pls_golite062009
purine ribonucleotide binding 0.511706857793891 bayes_pls_golite062009
ribonucleotide binding 0.511646852033539 bayes_pls_golite062009
purine nucleotide binding 0.511126133432142 bayes_pls_golite062009
nucleotide binding 0.503624561336457 bayes_pls_golite062009
molecular adaptor activity 0.494024302340603 bayes_pls_golite062009
tubulin binding 0.488928950975855 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.476542772435059 bayes_pls_golite062009
actin binding 0.464111806616899 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.409062479526042 bayes_pls_golite062009
protein binding, bridging 0.370788151516215 bayes_pls_golite062009
microtubule binding 0.196718452862042 bayes_pls_golite062009
transporter activity 0.187543377461637 bayes_pls_golite062009
transmembrane transporter activity 0.0413380592707298 bayes_pls_golite062009
alpha-actinin binding 0.00586886096202299 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle