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Protein Overview: DIP1-PB

General Information:
Name(s) found: DIP1-PB / FBpp0077063 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene DISCO Interacting Protein 1 is referred to in FlyBase by the symbol Dmel\DIP1 (CG17686, FBgn0024807). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:21495823..21501185. It has the cytological map location 20A4-20A5. There is experimental evidence that it has the molecular function</span>: double-stranded RNA binding; protein binding. The biological processes in which it is involved are not known. 18 alleles are reported. The phenotypes of these alleles are annotated with: eye; antenna; wing margin bristle; head capsule; haltere; wing; arista; capitellum; wing vein. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 409 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    chromatin [NAS]
    Biological Process: NONE FOUND
    Molecular Function: protein binding [IPI]
    double-stranded RNA binding [IDA][ISS][NAS]
    chromatin binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSVGQRVAF LSTHWTSPLQ NPNATVKPLI QMPLQAANVQ EQQSSPVALY PTSASPVAVQ  60
   61 SPQDAFLAVQ SPGAPAPVQL ANSSDQQNNP DADAIASKLP MPVIIKEEPI SVNDEPSVDN 120
  121 IEDNTSASTS ASGIGGKIPF KKIFQKRKKS SERTRDKKLR QNRQLRKSML PKNALMALNE 180
  181 VKGVTISDFT IDSNTDGGFT AVVTVNSNQY EGKGTSKMTA KNAACEKAWR DFIIAKMTPK 240
  241 PPRIHQVEMG SEPMDINEDE ADAPDDDLPM LNLASFAIYK LFAEWEREGY VVPEMHPSAN 300
  301 AAQQAGGDAG TPVPPVPKEP KKPPVRTELP SGWETMHPAT ILCIMRPGLN YVDYGSSGDK 360
  361 TNGMQHLGIM VDNQEFHANG RSKKIARRNV AVKVCNSLFG TNFTYSDTT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] PSI-BLAST 17.69897 dsRNA-dependent protein kinase pkr
    2 View Details [238..409] PSI-BLAST 17.69897 RNase III endonuclease catalytic domain; RNase III, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.94193673826237 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.04630961873875 bayes_pls_golite062009
  • RNA binding
    		•  0.41703783699663 bayes_pls_golite062009
  • protein binding
    		•  0.32114973384806 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  1.94193673826237 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.04630961873875 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.868825189258668 bayes_pls_golite062009
  • nuclease activity
    		•  0.810795014450932 bayes_pls_golite062009
  • endonuclease activity
    		•  0.808265327042919 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.580369692270212 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.540638671994607 bayes_pls_golite062009
  • RNA binding
    		•  0.41703783699663 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.323139941667645 bayes_pls_golite062009
  • protein binding
    		•  0.32114973384806 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle