Protein Overview: vav-PA, vav-PB

General Information:
Name(s) found:	vav-PB / FBpp0074449 [FlyBase] vav-PA / FBpp0074448 [FlyBase]
Description(s) found: Found 36 descriptions. SHOW ALL	The gene vav is referred to in FlyBase by the symbol Dmel\vav (CG7893, FBgn0040068). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19155864..19167312. It has the cytological map location 18B6-18B7. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity; diacylglycerol binding; Rho GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; cell adhesion; actin filament organization. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene vav is referred to in FlyBase by the symbol Dmel\vav (CG7893, FBgn0040068). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19155864..19167312. It has the cytological map location 18B6-18B7. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity; diacylglycerol binding; Rho GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; cell adhesion; actin filament organization. 6 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	793 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	regulation of cell shape [IMP] regulation of Rho protein signal transduction [IEA] actin filament organization [IMP] cell adhesion [IMP] Rho protein signal transduction [ISS]
Molecular Function:	protein binding [IEA] guanyl-nucleotide exchange factor activity [ISS] diacylglycerol binding [ISS] Rho GTPase activator activity [ISS] Rho guanyl-nucleotide exchange factor activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSSSSNSF GGVAGVNGDL WRECVAWLTR CKVIPPDHKA AQPDAEIRIL AMTLRDGVLL  60
   61 CNLVIHLDPS SLDPREFNRK PQMAQFLCSK NIKLFLDVCH NNFGIRDADL FEPTMLYDLT 120
  121 NFHRVLITLS KLSQCRKVQQ LHPDLIGFNL QLSPTERSHS DEAIYKDLHS TTTDNIACNG 180
  181 TGYDHTNTKE EEVYQDLCAL HRTSRSQTAS STSFEQRDYV IRELIDTESN YLDVLTALKT 240
  241 KFMGPLERHL NQDELRLIFP RIRELVDIHT KFLDKLRESL TPNAKVKMAQ VFLDFREPFL 300
  301 IYGEFCSLLL GAIDYLADVC KKNQIIDQLV QKCERDYNVG KLQLRDILSV PMQRILKYHL 360
  361 LLDKLVKETS PLHDDYRSLE RAKEAMIDVS QYINEVKRDS DHLVIIQKVK DSICDIHLLQ 420
  421 NGNGSDLLQY GRLLLDGELH IKAHEDQKTK LRYAFVFDKI LIMVKALHIK TGDMQYTYRD 480
  481 SHNLADYRVE QSHSRRTIGR DTRFKYQLLL ARKSGKTAFT LYLKSEHERD KWRKALTEAM 540
  541 ESLEPPGCQS TDHKMEIYTF DAPTTCRHCS KFLKGRIHQG YRCKVCQISV HKGCISSTGR 600
  601 CKQNPVSVPP PVCDRQLSEF NWFAGNMDRE TAAHRLENRR IGTYLLRVRP QGPSTAHETM 660
  661 YALSLKTDDN VIKHMKINQE NSGDSMLYCL SSRRHFKTIV ELVSYYERND LGENFAGLNQ 720
  721 SLQWPYKEVI ATALYDYEPK AGSNQLQLRT DCQVLVIGKD GDSKGWWRGK IGDTVGYFPK 780
  781 EYVQEQKLAS EEL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
molecular transducer activity	3.13508395312263	bayes_pls_golite062009
signal transducer activity	3.13508395312263	bayes_pls_golite062009
binding	2.48735671726158	bayes_pls_golite062009
protein binding	2.14586566310919	bayes_pls_golite062009
cytoskeletal protein binding	2.02807082768447	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
actin binding	1.61769239689139	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
receptor binding	1.02111138016453	bayes_pls_golite062009
transporter activity	0.896907103596953	bayes_pls_golite062009
protein kinase activity	0.866297952372595	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
actin filament binding	0.81415274660559	bayes_pls_golite062009
transmembrane transporter activity	0.713068405985864	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.672113434569322	bayes_pls_golite062009
kinase activity	0.613339968424942	bayes_pls_golite062009
nucleic acid binding	0.548932476087721	bayes_pls_golite062009
transcription regulator activity	0.489780129542396	bayes_pls_golite062009
enzyme regulator activity	0.456661966897198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.402293396718198	bayes_pls_golite062009
DNA binding	0.33967993424008	bayes_pls_golite062009
substrate-specific transporter activity	0.245869952317152	bayes_pls_golite062009
kinase binding	0.131981353175621	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.0273219613963591	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.88

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..138]	PSI-BLAST	27.69897	No description for 2d86A was found.
2	View Details	[139..546]	PSI-BLAST	48.69897	No description for 2dx1A was found.
3	View Details	[547..793]	PSI-BLAST	11.39794	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)

Protein Overview: vav-PA, vav-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: