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View Structure Prediction Details

Protein: vav-PA, vav-PB
Organism: Drosophila melanogaster
Length: 793 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vav-PA, vav-PB.

Description E-value Query
Range
Subject
Range
gi|6822326 - gi|6822326|gb|AAF28765.1|AF218780_1 VAV protein [Drosophila melanogaster]
363.0 [0..1] [793..1]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSSSSNSF GGVAGVNGDL WRECVAWLTR CKVIPPDHKA AQPDAEIRIL AMTLRDGVLL  60
   61 CNLVIHLDPS SLDPREFNRK PQMAQFLCSK NIKLFLDVCH NNFGIRDADL FEPTMLYDLT 120
  121 NFHRVLITLS KLSQCRKV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.69897
Match: 2d86A
Description: No description for 2d86A was found.

Predicted Domain #2
Region A:
Residues: [139-546]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQLHPDLIGF NLQLSPTERS HSDEAIYKDL HSTTTDNIAC NGTGYDHTNT KEEEVYQDLC  60
   61 ALHRTSRSQT ASSTSFEQRD YVIRELIDTE SNYLDVLTAL KTKFMGPLER HLNQDELRLI 120
  121 FPRIRELVDI HTKFLDKLRE SLTPNAKVKM AQVFLDFREP FLIYGEFCSL LLGAIDYLAD 180
  181 VCKKNQIIDQ LVQKCERDYN VGKLQLRDIL SVPMQRILKY HLLLDKLVKE TSPLHDDYRS 240
  241 LERAKEAMID VSQYINEVKR DSDHLVIIQK VKDSICDIHL LQNGNGSDLL QYGRLLLDGE 300
  301 LHIKAHEDQK TKLRYAFVFD KILIMVKALH IKTGDMQYTY RDSHNLADYR VEQSHSRRTI 360
  361 GRDTRFKYQL LLARKSGKTA FTLYLKSEHE RDKWRKALTE AMESLEPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.69897
Match: 2dx1A
Description: No description for 2dx1A was found.

Predicted Domain #3
Region A:
Residues: [547-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GCQSTDHKME IYTFDAPTTC RHCSKFLKGR IHQGYRCKVC QISVHKGCIS STGRCKQNPV  60
   61 SVPPPVCDRQ LSEFNWFAGN MDRETAAHRL ENRRIGTYLL RVRPQGPSTA HETMYALSLK 120
  121 TDDNVIKHMK INQENSGDSM LYCLSSRRHF KTIVELVSYY ERNDLGENFA GLNQSLQWPY 180
  181 KEVIATALYD YEPKAGSNQL QLRTDCQVLV IGKDGDSKGW WRGKIGDTVG YFPKEYVQEQ 240
  241 KLASEEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.39794
Match: 1griA
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
molecular transducer activity 3.13508395312263 bayes_pls_golite062009
signal transducer activity 3.13508395312263 bayes_pls_golite062009
binding 2.48735671726158 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
cytoskeletal protein binding 2.02807082768447 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
actin binding 1.61769239689139 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
receptor binding 1.02111138016453 bayes_pls_golite062009
transporter activity 0.896907103596953 bayes_pls_golite062009
protein kinase activity 0.866297952372595 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
actin filament binding 0.81415274660559 bayes_pls_golite062009
transmembrane transporter activity 0.713068405985864 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.672113434569322 bayes_pls_golite062009
kinase activity 0.613339968424942 bayes_pls_golite062009
nucleic acid binding 0.548932476087721 bayes_pls_golite062009
transcription regulator activity 0.489780129542396 bayes_pls_golite062009
enzyme regulator activity 0.456661966897198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.402293396718198 bayes_pls_golite062009
DNA binding 0.33967993424008 bayes_pls_golite062009
substrate-specific transporter activity 0.245869952317152 bayes_pls_golite062009
kinase binding 0.131981353175621 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.0273219613963591 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle