Protein Overview: beta-Spec-PA

General Information:
Name(s) found:	beta-Spec-PA / FBpp0074228 [FlyBase]
Description(s) found: Found 21 descriptions. SHOW ALL	The gene Ă?Ă?Â˛ Spectrin is referred to in FlyBase by the symbol Dmel\Ă?Ă?Â˛-Spec (CG5870, FBgn0250788). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17551454..17563270. It has the cytological map location 16B10-16B12. There is experimental evidence that it has the molecular function</span>: phosphatidylinositol-4,5-bisphosphate binding; microtubule binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of microtubule depolymerization; neuromuscular synaptic transmission; regulation of synapse organization; long-term strengthening of neuromuscular junction; axon guidance; maintenance of presynaptic active zone structure; axonogenesis; axon midline choice point recognition. 30 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: multi-cell-component structure; commissure; organ system; embryonic nervous system; anatomical structure; nervous system; hub cell; site of polarized growth; cytoplasmic part; synapse; postsynaptic membrane. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	2291 amino acids
Gene Ontology:
Cellular Component:	lipid particle [IDA] apicolateral plasma membrane [TAS] lateral plasma membrane [IDA] neuromuscular junction [IDA] fusome [IDA] spectrosome [IDA][TAS] spectrin [ISS][NAS] plasma membrane [IDA] axon [IDA]
Biological Process:	plasma membrane organization [TAS] maintenance of presynaptic active zone structure [IDA] neuromuscular synaptic transmission [IMP] regulation of synapse organization [IMP] long-term strengthening of neuromuscular junction [IMP] axonogenesis [IMP] fusome organization [TAS] axon guidance [IMP] negative regulation of microtubule depolymerization [IMP] axon midline choice point recognition [IMP] spectrosome organization [TAS]
Molecular Function:	actin filament binding [ISS] phosphatidylinositol-4,5-bisphosphate binding [IDA] calmodulin binding [ISS][NAS] actin binding [ISS][NAS] structural constituent of cytoskeleton [IEA] cytoskeletal protein binding [ISS] microtubule binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTDISIVRW DPSQGPGNEY IDEYEYDGGN SSSRLFERSR IKALAEERES VQKKTFTKWV  60
   61 NSHLCRVNCR IADLYVDMRD GKHLIKLLEV LSGERLPKPT KGKMRIHCLE NVDKALQFLR 120
  121 EQRVHLENIG SHDIVDGNAS LNLGLIWTII LRFQIQDITI EEVDNKETKS AKDALLLWCQ 180
  181 MKTAGYHNVN VRNFTTSWRD GLAFNAIIHK HRPDLVQFEK LSKTNAIHNL NNAFDVAEDK 240
  241 LGLAKLLDAE DVFVEHPDEK SIITYVVTYY HYFSKLKQET VQGKRIGKVV GIAMENDKMV 300
  301 HDYENFTSDL LKWIETTIQS LGEREFENSL AGVQGQLAQF SNYRTIEKPP KFVEKGNLEV 360
  361 LLFTLQSKMR ANNQKPYTPK EGKMISDINK AWERLEKAEH ERELALREEL IRQEKLEQLA 420
  421 ARFDRKASMR ETWLSENQRL VSQDNFGFDL AAVEAAAKKH EAIETDIFAY EERVQAVVAV 480
  481 CDELESERYH DVKRILLRKD NVMRLWTYLL ELLRARRMRL EISLQLQQNF QEMLYILDNM 540
  541 EEIKQLLMTD DYGKHLMGVE DLLQKHSLVE ADINILGERV KVVVQNSQKF LSDDPESYKP 600
  601 CDPEIIVSRV QQLEDAYAEL VRLAVERRSR LEESRKLWQF YWDTADEENW IKEKEQIVST 660
  661 DEVGHDLTTV NLMLSKHKAL ESEITSHDPQ LQNVAKVGSE LITEGHFGAD RIKDRLKEIL 720
  721 NKWDHLLDLT KYRRQRLENA VEYFQLFADA DDVDNWMLDT LRIVSSEDVG RDEANVQSLL 780
  781 KKHKDVADEL KNYAEVIDAL HKQAESLKLN EAEKANVDKR LEAIDNRYKE LTELAKLRKQ 840
  841 RLLDALSLYK LMSEADGVEQ WIKEKTKMLD TMTPGKDIED VEIMKHRFEG FDKEMNANAS 900
  901 RVAVVNQLAR QLLHVEHPNS DEILERQNHL NQEWSTLREK AEAKMDDLKS AHGVQTFYIE 960
  961 CRETISWIED KKRILTETDS LEMDLTGVMT LQRRLSGMDR DLAAIQAKLS SLEREANSIE1020
 1021 DEHPEEAKII RERIAQIELI WEQLTQMLKE RDSKLEEAGD LHRFLRDLDH FQTWLTKTQT1080
 1081 DVASEDTPTS LPEAEKLLNQ HQSIREEIDN YTEDYKNMME YGERLTSEGS TSDDPQYMFL1140
 1141 RERLNALKDG WEELHQMWEN RQVLLSQSLD QQLFNRDARQ TEVLLSQQEH FLSKDDTPVN1200
 1201 LEQAENQLKR HEAFLTTMEA NDDKINTLLQ VADTLVEKDH FDADKIGKRA ENITGRRDDN1260
 1261 RQRALDQHEK LKNQVKLHEF LQDLEELAEW VQEKYATSQD ESYRSAKTIH SKWTRHQAFE1320
 1321 AEIAANKERL FEAEKSAQEL SKEKPEFKDV IEPKLKELAK QFDDLEVHTK EKGAMLFDAN1380
 1381 REVLVQQTCD DIDSYITDLE KQIVSGDTAN DLTSVNILMQ KQQVIQTQMA VKARQVEEID1440
 1441 KQTEYLQKTV PEEKIEPIVV KKTAVLERFE KIKAPLLERQ KALEKKKEAF QFCRDVEDEK1500
 1501 LWIDEKLPVA NSPDYGNSLF NVHVLKKKNQ SLATEIDNHE PRINAICNNG RKLIDEGHED1560
 1561 AKKFEALISD LTQKWQELKD AIENRRKHLL ESEKVQQYFF DAQEAESWMS EQELYMMVED1620
 1621 RGKDEISAQN LMKKHENLEQ SVEDYANTIR QLGEVARQFS GDDISSGDAV AVKQSQLDKL1680
 1681 YAGLKDLAGE RRARLNEALQ LFMLSREVDD LEQWITDREV VAGSQELGQD FDHVTLLSER1740
 1741 FNEFARDTEA VGGERVAKVN GIADNLIQAG HSDSATIAEW KDNLNESWQD LLELIETRTQ1800
 1801 MLAASRELHK FFHDCKDVLG RILEKQHGVS DELGRDAGSV STLQRKHYNF LQDLITLYSQ1860
 1861 VQQIQEESAK LQDAYAGDKA KEITNREQEV LHAWDNLQAM CDARKQKLAD TGDLFRFFNM1920
 1921 VRILMIWMED LVRQMNTSEK PRDVSGVELL MNNHQSLKAE IDTREDNFGA CISLGKELLT1980
 1981 RNHYASADIK DRLMTLSNSR NALLRRWEER WENLQLILEV YQFARDAAVA EAWLIAQEPY2040
 2041 LLSSELGHTI DEVENLIKKH EAFEKSAAAQ EERFSALERL TTFELKEMKR RQELAEEAER2100
 2101 QRIKEEQEAK AASEAAEQAK REAERRDDVD VGASHDDSER GGTPGAGEGH EGYVTRKHEW2160
 2161 DSTTKKASNR SWDKVYMAAK AGRISFYKDQ KGYKSNPELT FRGEPSYDLQ NAAIEIASDY2220
 2221 TKKKHVLRVK LANGALFLLQ AHDDTEMSQW VTSLKAQSDS TAVAASRSQT LPATSQKDEP2280
 2281 KRRSFFTLKK K

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: beta-Spec-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: