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Protein Overview: X11L-PA

General Information:
Name(s) found: X11L-PA / FBpp0074225 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene X11L is referred to in FlyBase by the symbol Dmel\X11L (CG5675, FBgn0026313). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17493644..17500912. It has the cytological map location 16B7. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. It is reported to be involved in the biological process</span>: establishment or maintenance of cell polarity; neurotransmitter secretion; synaptic vesicle docking during exocytosis; synaptic vesicle targeting. 8 alleles are reported. The phenotypes of these alleles are annotated with: medulla neuropil; rhabdomere; interommatidial bristle; primary pigment cell; four cone-cell ommatidial precursor cluster; ommatidial precursor cluster; ommatidium; lamina neuropil. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1167 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    plasma membrane [IDA]
    Biological Process: synaptic vesicle targeting [NAS]
    synaptic vesicle docking during exocytosis [NAS]
    establishment or maintenance of cell polarity [NAS]
    neurotransmitter secretion [NAS]
    Molecular Function: protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSNSCSDSS NESMVNPPHI QMNFGQQAQQ QQSHQHQQQQ QQQERYVWEM RTRSPNVTPA  60
   61 STVLNSPDLN GELSYVPLQG LSPSGGGVQG SGSYGSNAGR DSGSYYYQRP QLHQIRLGRS 120
  121 PGSQFETRDV LPQGLASPGS PTDVGKADGQ CLRDGEIVVF DDIDTNWMNK ASSGQRPGSN 180
  181 EDVLKVTKMI GQLPIAEYEG SPRRFGSQPN TNTITMGGPR KRPPGFPQRV SPTTSVANNA 240
  241 TAAAKASVGN LIDLVDHEEE RSGTLREKTP TFDYLYEFSE TRKVLEEFFK ANPEDEKRYT 300
  301 DYTTESGDDV ASSPQEYPAT PMEQAYIGQR LARIPKDELY MVHRSPTKKP PSDQNPSTAY 360
  361 QEHNDIELYI DSNSRSSGDL ADTELEANLR RHSRNFTLSP ETTDYDSNCG DLDSLSNDIN 420
  421 CPTDFGKLYT SMPVLEDGLS SGHASDTENN VSVVCDKQQS SQSQPVHEHN GNGERLENDY 480
  481 NVMSASLATL TTDASQSALI SDFASLPMPP APPPSSPPQI EIADASESMT MVPDADNPLD 540
  541 SHYGAVYAAA LGGTHTEKSA GSGLGVTPVT AGGSLPSQAA SEIQEAMKEI RSALQRAKTQ 600
  601 PEKLKFCDEV LPTDPDSPVW VPRKGTTIST AQGAAADEEP DTDLETDRLL GQQRHDEQDF 660
  661 FADQSLADNN ANEGTDIASN GHLNGTSDNN NPNPMNNSKP QTYSTATIRQ GIGTSLTPNS 720
  721 PDICQIVGTT DISISSPEKL QFTKSPTGSI KSLKDSANSD KKAKSRNKEG LLEPKVLIEG 780
  781 VLFRARYLGS TQLVCEGQPT KSTRMMQAEE AVSRIKAPEG ESQPSTEVDL FISTEKIMVL 840
  841 NTDLKEIMMD HALRTISYIA DIGDLVVLMA RRRFVPNSVV DPSITSPLGD VPTPGIGEEE 900
  901 SPPKEPLSKH NRTPKMICHV FESDEAQFIA QSIGQAFQVA YMEFLKANGI ENESLAKEMD 960
  961 YQEVLNSQEI FGDELEIFAK KELQKEVVVP KAKGEILGVV IVESGWGSML PTVVIANLMS1020
 1021 SGAAARCGQL NIGDQLIAIN GMSLVGLPLS TCQSYIRNAK NQTAVKFTVV PCPPVVEVKI1080
 1081 LRPKALFQLG FSVQNGVICS LLRGGIAERG GVRVGHRIIE INNQSVVAVP HDTIVKLLSS1140
 1141 SVGEILMKTM PTSMFRLLTG QETPIYI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..222] deduced N/A No confident structure predictions are available.
    2 View Details [223..421] MSA 1.199994 View MSA. No confident structure predictions are available.
    3 View Details [422..599] MSA 3.252997 View MSA. No confident structure predictions are available.
    4 View Details [600..763] deduced N/A No confident structure predictions are available.
    5 View Details [764..972] FFAS03 2.32 X11
    6 View Details [973..1167] PSI-BLAST 51.39794 Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.32408664703719 bayes_pls_golite062009
  • protein binding
    		•  1.85780451223644 bayes_pls_golite062009
  • signal transducer activity
    		•  1.33652392843319 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.33652392843319 bayes_pls_golite062009
  • transporter activity
    		•  1.29925758003665 bayes_pls_golite062009
  • phospholipid binding
    		•  0.864843473490307 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.650240628628722 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.552872712432362 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.45899353522401 bayes_pls_golite062009
  • receptor binding
    		•  0.391425518916624 bayes_pls_golite062009
  • receptor activity
    		•  0.257794982570723 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.102504792589299 bayes_pls_golite062009
    6
    Term Confidence Notes
  • binding
    		•  2.4211406884996 bayes_pls_golite062009
  • protein binding
    		•  2.25893018754605 bayes_pls_golite062009
  • transporter activity
    		•  1.18978519116375 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07211582292329 bayes_pls_golite062009
  • PDZ domain binding
    		•  0.87883331498113 bayes_pls_golite062009
  • signal transducer activity
    		•  0.877891218909175 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.877891218909175 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.64214865642772 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.500408526353621 bayes_pls_golite062009
  • receptor binding
    		•  0.359972518335054 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.304039235146353 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252733105474942 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle