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View Structure Prediction Details

Protein: X11L-PA
Organism: Drosophila melanogaster
Length: 1167 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for X11L-PA.

Description E-value Query
Range
Subject
Range
gi|11494014 - gi|11494014|gb|AAG35737.1|AF208839_1 DX11 [Drosophila melanogaster]
880.0 [0..14] [1167..14]

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Predicted Domain #1
Region A:
Residues: [1-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSNSCSDSS NESMVNPPHI QMNFGQQAQQ QQSHQHQQQQ QQQERYVWEM RTRSPNVTPA  60
   61 STVLNSPDLN GELSYVPLQG LSPSGGGVQG SGSYGSNAGR DSGSYYYQRP QLHQIRLGRS 120
  121 PGSQFETRDV LPQGLASPGS PTDVGKADGQ CLRDGEIVVF DDIDTNWMNK ASSGQRPGSN 180
  181 EDVLKVTKMI GQLPIAEYEG SPRRFGSQPN TNTITMGGPR KR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [223-421]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPGFPQRVSP TTSVANNATA AAKASVGNLI DLVDHEEERS GTLREKTPTF DYLYEFSETR  60
   61 KVLEEFFKAN PEDEKRYTDY TTESGDDVAS SPQEYPATPM EQAYIGQRLA RIPKDELYMV 120
  121 HRSPTKKPPS DQNPSTAYQE HNDIELYIDS NSRSSGDLAD TELEANLRRH SRNFTLSPET 180
  181 TDYDSNCGDL DSLSNDINC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [422-599]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTDFGKLYTS MPVLEDGLSS GHASDTENNV SVVCDKQQSS QSQPVHEHNG NGERLENDYN  60
   61 VMSASLATLT TDASQSALIS DFASLPMPPA PPPSSPPQIE IADASESMTM VPDADNPLDS 120
  121 HYGAVYAAAL GGTHTEKSAG SGLGVTPVTA GGSLPSQAAS EIQEAMKEIR SALQRAKT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [600-763]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPEKLKFCDE VLPTDPDSPV WVPRKGTTIS TAQGAAADEE PDTDLETDRL LGQQRHDEQD  60
   61 FFADQSLADN NANEGTDIAS NGHLNGTSDN NNPNPMNNSK PQTYSTATIR QGIGTSLTPN 120
  121 SPDICQIVGT TDISISSPEK LQFTKSPTGS IKSLKDSANS DKKA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [764-972]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSRNKEGLLE PKVLIEGVLF RARYLGSTQL VCEGQPTKST RMMQAEEAVS RIKAPEGESQ  60
   61 PSTEVDLFIS TEKIMVLNTD LKEIMMDHAL RTISYIADIG DLVVLMARRR FVPNSVVDPS 120
  121 ITSPLGDVPT PGIGEEESPP KEPLSKHNRT PKMICHVFES DEAQFIAQSI GQAFQVAYME 180
  181 FLKANGIENE SLAKEMDYQE VLNSQEIFG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.32
Match: 1aqcA
Description: X11
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.32408664703719 bayes_pls_golite062009
protein binding 1.85780451223644 bayes_pls_golite062009
signal transducer activity 1.33652392843319 bayes_pls_golite062009
molecular transducer activity 1.33652392843319 bayes_pls_golite062009
transporter activity 1.29925758003665 bayes_pls_golite062009
phospholipid binding 0.864843473490307 bayes_pls_golite062009
protein domain specific binding 0.650240628628722 bayes_pls_golite062009
substrate-specific transporter activity 0.552872712432362 bayes_pls_golite062009
phosphoinositide binding 0.45899353522401 bayes_pls_golite062009
receptor binding 0.391425518916624 bayes_pls_golite062009
receptor activity 0.257794982570723 bayes_pls_golite062009
transmembrane receptor activity 0.102504792589299 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [973-1167]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DELEIFAKKE LQKEVVVPKA KGEILGVVIV ESGWGSMLPT VVIANLMSSG AAARCGQLNI  60
   61 GDQLIAINGM SLVGLPLSTC QSYIRNAKNQ TAVKFTVVPC PPVVEVKILR PKALFQLGFS 120
  121 VQNGVICSLL RGGIAERGGV RVGHRIIEIN NQSVVAVPHD TIVKLLSSSV GEILMKTMPT 180
  181 SMFRLLTGQE TPIYI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1u3bA
Description: Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.4211406884996 bayes_pls_golite062009
protein binding 2.25893018754605 bayes_pls_golite062009
transporter activity 1.18978519116375 bayes_pls_golite062009
transmembrane transporter activity 1.07211582292329 bayes_pls_golite062009
PDZ domain binding 0.87883331498113 bayes_pls_golite062009
signal transducer activity 0.877891218909175 bayes_pls_golite062009
molecular transducer activity 0.877891218909175 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
substrate-specific transporter activity 0.500408526353621 bayes_pls_golite062009
receptor binding 0.359972518335054 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.304039235146353 bayes_pls_golite062009
active transmembrane transporter activity 0.252733105474942 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle