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View Structure Prediction Details

Protein: X11L-PA
Organism: Drosophila melanogaster
Length: 1167 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for X11L-PA.

Description E-value Query
Range
Subject
Range
gi|11494014 - gi|11494014|gb|AAG35737.1|AF208839_1 DX11 [Drosophila melanogaster]
880.0 [0..14] [1167..14]

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Predicted Domain #1
Region A:
Residues: [1-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSNSCSDSS NESMVNPPHI QMNFGQQAQQ QQSHQHQQQQ QQQERYVWEM RTRSPNVTPA  60
   61 STVLNSPDLN GELSYVPLQG LSPSGGGVQG SGSYGSNAGR DSGSYYYQRP QLHQIRLGRS 120
  121 PGSQFETRDV LPQGLASPGS PTDVGKADGQ CLRDGEIVVF DDIDTNWMNK ASSGQRPGSN 180
  181 EDVLKVTKMI GQLPIAEYEG SPRRFGSQPN TNTITMGGPR KR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [223-421]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPGFPQRVSP TTSVANNATA AAKASVGNLI DLVDHEEERS GTLREKTPTF DYLYEFSETR  60
   61 KVLEEFFKAN PEDEKRYTDY TTESGDDVAS SPQEYPATPM EQAYIGQRLA RIPKDELYMV 120
  121 HRSPTKKPPS DQNPSTAYQE HNDIELYIDS NSRSSGDLAD TELEANLRRH SRNFTLSPET 180
  181 TDYDSNCGDL DSLSNDINC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [422-599]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTDFGKLYTS MPVLEDGLSS GHASDTENNV SVVCDKQQSS QSQPVHEHNG NGERLENDYN  60
   61 VMSASLATLT TDASQSALIS DFASLPMPPA PPPSSPPQIE IADASESMTM VPDADNPLDS 120
  121 HYGAVYAAAL GGTHTEKSAG SGLGVTPVTA GGSLPSQAAS EIQEAMKEIR SALQRAKT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [600-763]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPEKLKFCDE VLPTDPDSPV WVPRKGTTIS TAQGAAADEE PDTDLETDRL LGQQRHDEQD  60
   61 FFADQSLADN NANEGTDIAS NGHLNGTSDN NNPNPMNNSK PQTYSTATIR QGIGTSLTPN 120
  121 SPDICQIVGT TDISISSPEK LQFTKSPTGS IKSLKDSANS DKKA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [764-972]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSRNKEGLLE PKVLIEGVLF RARYLGSTQL VCEGQPTKST RMMQAEEAVS RIKAPEGESQ  60
   61 PSTEVDLFIS TEKIMVLNTD LKEIMMDHAL RTISYIADIG DLVVLMARRR FVPNSVVDPS 120
  121 ITSPLGDVPT PGIGEEESPP KEPLSKHNRT PKMICHVFES DEAQFIAQSI GQAFQVAYME 180
  181 FLKANGIENE SLAKEMDYQE VLNSQEIFG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.32
Match: 1aqcA
Description: X11
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.32408664703719 bayes_pls_golite062009
protein binding 1.85780451223644 bayes_pls_golite062009
signal transducer activity 1.33652392843319 bayes_pls_golite062009
molecular transducer activity 1.33652392843319 bayes_pls_golite062009
transporter activity 1.29925758003665 bayes_pls_golite062009
phospholipid binding 0.864843473490307 bayes_pls_golite062009
protein domain specific binding 0.650240628628722 bayes_pls_golite062009
substrate-specific transporter activity 0.552872712432362 bayes_pls_golite062009
phosphoinositide binding 0.45899353522401 bayes_pls_golite062009
receptor binding 0.391425518916624 bayes_pls_golite062009
receptor activity 0.257794982570723 bayes_pls_golite062009
transmembrane receptor activity 0.102504792589299 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [973-1167]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DELEIFAKKE LQKEVVVPKA KGEILGVVIV ESGWGSMLPT VVIANLMSSG AAARCGQLNI  60
   61 GDQLIAINGM SLVGLPLSTC QSYIRNAKNQ TAVKFTVVPC PPVVEVKILR PKALFQLGFS 120
  121 VQNGVICSLL RGGIAERGGV RVGHRIIEIN NQSVVAVPHD TIVKLLSSSV GEILMKTMPT 180
  181 SMFRLLTGQE TPIYI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1u3bA
Description: Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.4211406884996 bayes_pls_golite062009
protein binding 2.25893018754605 bayes_pls_golite062009
transporter activity 1.18978519116375 bayes_pls_golite062009
transmembrane transporter activity 1.07211582292329 bayes_pls_golite062009
PDZ domain binding 0.87883331498113 bayes_pls_golite062009
signal transducer activity 0.877891218909175 bayes_pls_golite062009
molecular transducer activity 0.877891218909175 bayes_pls_golite062009
protein domain specific binding 0.64214865642772 bayes_pls_golite062009
substrate-specific transporter activity 0.500408526353621 bayes_pls_golite062009
receptor binding 0.359972518335054 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.304039235146353 bayes_pls_golite062009
active transmembrane transporter activity 0.252733105474942 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle