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Protein Overview: B-H1-PA

General Information:
Name(s) found: B-H1-PA / FBpp0074204 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene BarH1 is referred to in FlyBase by the symbol Dmel\B-H1 (CG5529, FBgn0011758). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17291534..17297312. It has the cytological map location 16A4-16A5. It is reported to have molecular function</span>: specific RNA polymerase II transcription factor activity; DNA binding; transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: sensory organ boundary specification; negative regulation of transcription; compound eye photoreceptor cell differentiation; leg disc proximal/distal pattern formation; eye-antennal disc morphogenesis; eye pigment granule organization; bristle morphogenesis. 11 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: external compound sense organ; peripheral nervous system; nervous system; adult segment; compound cell cluster organ; metatarsus; thoracic segment; appendage segment; morphogenetic furrow; imaginal precursor. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 544 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: sensory organ boundary specification [IMP]
    compound eye photoreceptor cell differentiation [IMP]
    bristle morphogenesis [IMP]
    negative regulation of transcription [IGI][IMP]
    eye-antennal disc morphogenesis [IMP]
    regulation of transcription, DNA-dependent [IEA][NAS]
    eye pigment granule organization [IMP]
    regulation of transcription [IEA]
    leg disc proximal/distal pattern formation [IMP]
    Molecular Function: DNA binding [NAS]
    transcription factor activity [IEA][NAS]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDSMSILTQ TPSEPNAAHP QLHHHLSTLQ QQHHQHHLHY GLQPPAVAHS IHSTTTMSSG  60
   61 GSTTTASGIG KPNRSRFMIN DILAGSAAAA FYKQQQHHQQ LHHHNNNNNS GSSGGSSPAH 120
  121 SNNNNNINGD NCEASNVAGV GVLPSALHHP QPHPPTHPHT HPHALMHPHG KLGHFPPTAG 180
  181 GNGLNVAQYA AAMQQHYAAA AAAAAARNNA AAAAAAAAAA AAAGVAAPPV DGGVDGGVGL 240
  241 APPAGGDLDD SSDYHEENED CDSGNMDDHS VCSNGGKDDD GNSVKSGSTS DMSGLSKKQR 300
  301 KARTAFTDHQ LQTLEKSFER QKYLSVQERQ ELAHKLDLSD CQVKTWYQNR RTKWKRQTAV 360
  361 GLELLAEAGN FAAFQRLYGG SPYLGAWPYA AAAGAAHGAT PHTNIDIYYR QAAAAAAMQK 420
  421 PLPYNLYAGV PSVGVGVGVG VGPAPFSHLS ASSSLSSLSS YYQSAAAAAS AANPGGPHPV 480
  481 APPPSVGGGS PPSGLVKPIP AHSASASPPP RPPSTPSPTL NPGSPPGRSV DSCSQSDDED 540
  541 QIQV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..126] MSA 1.20599 View MSA. No confident structure predictions are available.
    2 View Details [127..240] deduced N/A No confident structure predictions are available.
    3 View Details [241..365] PSI-BLAST 11.30103 Homeobox protein hox-b1
    4 View Details [366..544] MSA 1.201987 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  2.6809639302471 bayes_pls_golite062009
  • DNA binding
    		•  2.45264254102339 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32767577674158 bayes_pls_golite062009
  • binding
    		•  2.12643314274039 bayes_pls_golite062009
  • transcription factor activity
    		•  1.9610710007594 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.71974400731667 bayes_pls_golite062009
  • protein binding
    		•  0.57484570028668 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.328460252819506 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.245215140763955 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0177888191364471 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.42

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle