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Protein Overview: eIF-2alpha-PA, F...

General Information:
Name(s) found: FBpp0309768 [FlyBase]
eIF-2alpha-PA / FBpp0074075 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=X:complement(16339588..16339918,16340218..16340912); ID=FBpp0309768; name=eIF-2alpha-PB; parent=FBgn0261609,FBtr0343016; dbxref=FlyBase:FBpp0309768,FlyBase_Annotation_IDs:CG9946-PB; MD5=e3f0b632583d5204c5d718cb0d2136ca; length=341; release=r5.56; species=Dmel; [FlyBase]
  • The gene eIF-2Ã?&#142;Ã?± is referred to in FlyBase by the symbol Dmel\eIF-2Ã?&#142;Ã?± (CG9946, FBgn0004925). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16339528..16341007. It has the cytological map location 14C6. There is experimental evidence that it has the molecular function</span>: translation initiation factor activity. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle elongation; mitotic spindle organization. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 341 amino acids

    Gene Ontology:
    Cellular Component: cytosol [ISS]
    eukaryotic translation initiation factor 2B complex [ISS]
    eukaryotic translation initiation factor 2 complex [ISS][NAS]
    Biological Process: mitotic spindle elongation [IMP]
    formation of translation initiation ternary complex [NAS]
    mitotic spindle organization [IMP]
    translational initiation [ISS]
    Molecular Function: GTP binding [NAS]
    translation initiation factor activity [IGI][ISS][NAS]
    RNA binding [IEA]
    tRNA binding [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALTSRFYNE RYPEIEDVVM VNVLSIAEMG AYVHLLEYNN IEGMILLSEL SRRRIRSINK  60
   61 LIRVGKTEPV VVIRVDKEKG YIDLSKRRVS PEDVEKCTER FAKAKAINSL LRHVADILGF 120
  121 EGNEKLEDLY QKTAWHFEKK YNNKTVAYDI FKQSVTDPTV FDECNLEPET KEVLLSNIKR 180
  181 KLVSPTVKIR ADIECSCYGY EGIDAVKASL TKGLELSTEE LPIRINLIAP PLYVMTTSTT 240
  241 KKTDGLKALE VAIEHIRAKT SEYDGEFKVI MAPKLVTAID EADLARRLER AEAENAQVAG 300
  301 DDDEEDGADQ EGMQFDPEKE FNHKGSGAGR ANEEDEEEEE D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..341] PSI-BLAST 61.69897 Solution structure of alpha subunit of human eIF2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • translation initiation factor activity
    		•  10.6089165352091 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  6.60650180781768 bayes_pls_golite062009
  • translation regulator activity
    		•  6.15562485158748 bayes_pls_golite062009
  • structural molecule activity
    		•  6.0174879876147 bayes_pls_golite062009
  • DNA binding
    		•  3.38561002225202 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.60981339834849 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  2.50756546575713 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  2.36609416429058 bayes_pls_golite062009
  • binding
    		•  2.263388192549 bayes_pls_golite062009
  • RNA binding
    		•  1.76502371106766 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.69669059514663 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.60662288414996 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.33094846641297 bayes_pls_golite062009
  • transferase activity
    		•  0.945564658432858 bayes_pls_golite062009
  • mRNA binding
    		•  0.883475899526061 bayes_pls_golite062009
  • transcription factor activity
    		•  0.859071050218437 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.77755643935497 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.474251377131502 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.47336621289748 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.47336621289748 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.448368263932591 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.40142383001471 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.33985916978927 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.16147560902991 bayes_pls_golite062009
  • protein binding
    		•  0.152645195799531 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle