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Protein Overview: CG6227-PA

General Information:
Name(s) found: CG6227-PA / FBpp0073828 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG6227 (CG6227, FBgn0030631). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15239152..15244054. It has the cytological map location 13B7-13B8. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA binding; ATP-dependent RNA helicase activity; RNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of alternative nuclear mRNA splicing, via spliceosome. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1224 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    spliceosomal complex [ISS]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    nuclear mRNA splicing, via spliceosome [ISS]
    Molecular Function: ATP binding [IEA]
    RNA helicase activity [ISS]
    mRNA binding [ISS]
    ATP-dependent RNA helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKSSGRDRD RERDRERERE RDRERERDRD RERDNRHDSR SRDYDMGKSR NGGGGGAGGG  60
   61 SRNMREDRKR GKDMISDRGK RDDKRRKCSR SKDYEKDNSP HYRRLDKDRD RDRDRDRQRE 120
  121 KEREREKEKE REKEKERERD KDRERDRQRE KESDSRRAAA AAPLIIPLLS TSCSEEEVEE 180
  181 IDKEEQQRRL EQEMIKRRER IERWRAERKR DTKAAVVAPS LVNSAKKWSL EDESEEDDSN 240
  241 PAPPLDSGKK DAEPDSPPSK FHSIRKRFDD DVVESKFSPV KRPTFSKSFG KLGIGLATKA 300
  301 EADIKKEPPP VDTKKEIKKK PEPVAAKMEI VEEPTVAAGE KTKKEPEQPH VGAKSEPEVE 360
  361 DKPQPEAEPE DEIDPLDAYM QEVNNEMRRV NNFVNPPAKS QGVVILTGVA KKKTTTLKKG 420
  421 EVIEQNMDSL EYSSEDELED IRDTAVNLAM KHRKELAKID HSSVTYAPFR KNFYVEVPEL 480
  481 TRMTAADVEK YRSDLEGIQV KGKGCPKPIK TWAQCGVSKK EMEVLRRLGF EKPTPIQCQA 540
  541 IPAIMSGRDL IGIAKTGSGK TLAFILPMFR HILDQPSMED GDGAIAIIMA PTRELCMQIG 600
  601 KDIRKFSKSL GLRPVCVYGG TGISEQIAEL KRGAEIIVCT PGRMIDMLAA NSGRVTNLRR 660
  661 VTYVVLDEAD RMFDMGFEPQ VMRIIDNVRP DRQTVMFSAT FPRQMEALAR RILKKPIEVI 720
  721 VGGRSVVCKE VEQHVVILND DAKFFKLLEL LGIYQEAGSI IVFVDKQENA DILLRDLMKA 780
  781 SYPCMSLHGG IDQFDRDSTI IDFKSGKVRL LIATSVAARG LDVKDLILVV NYDVPNHYED 840
  841 YVHRCGRTGR AGKKGSAYTF ITPEQSRYAG DIIRAMDLSG TLIPAELQAL WTEYKALQEA 900
  901 EGKTVHTGGG FSGKGFKFDE QEFNAAKESK KLQKAALGLA DSDDEEDIEQ DIDQQIEQIF 960
  961 AAKRTVKDTS AAATAAAAAA AAAAAAAAAV SGANPALASA AAQAAAAAAA ANIAIAAASA1020
 1021 PAAAGGAPSV AMGGALSSDK LELAKRLASK INSSKNLDTK GSVVTVEPMI KGPHVTGAAA1080
 1081 TLLTARTVAE QMAAKLNNKL NYQPKEDEEG LGPLVGGTTN PFTKYEEELE INDFPQQARW1140
 1141 KVTSKEALAQ ISEYSEAGLT VRGTYVPQGK NPPDGERKLY LAIESCSELA VQKAKREITR1200
 1201 LIKEELLKLS SAHHVFNKGR YKVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] MSA 4.121996 View MSA. No confident structure predictions are available.
    2 View Details [94..216] deduced N/A No confident structure predictions are available.
    3 View Details [217..458] FFAS03 1.45 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    4 View Details [459..509] PSI-BLAST 109.0 No description for 2db3A was found.
    5 View Details [510..713] FFAS03 9.43 No description for 2gxqA was found.
    6 View Details [714..941] PSI-BLAST 38.221849 No description for 2hjvA was found.
    7 View Details [942..1112] deduced N/A No confident structure predictions are available.
    8 View Details [1113..1224] MSA 2.125983 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.38

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle