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Protein Overview: HDAC6-PB

General Information:
Name(s) found: HDAC6-PB / FBpp0073827 [FlyBase]
Description(s) found:
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  • gi|24642144|ref|NP_727842.1| HDAC6, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|22833160|gb|AAN09661.1| HDAC6, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579966|gb|ACN94226.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579948|gb|ACN94210.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579930|gb|ACN94194.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579921|gb|ACN94186.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579903|gb|ACN94170.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579894|gb|ACN94162.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579885|gb|ACN94154.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579876|gb|ACN94146.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579867|gb|ACN94138.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579858|gb|ACN94130.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579840|gb|ACN94114.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579804|gb|ACN94082.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579795|gb|ACN94074.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579777|gb|ACN94058.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|225579768|gb|ACN94050.1| histone deacetylase 6 isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene HDAC6 is referred to in FlyBase by the symbol Dmel\HDAC6 (CG6170, FBgn0026428). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15226988..15234394. It has the cytological map location 13B6. There is experimental evidence that it has the molecular function</span>: histone deacetylase activity. There is experimental evidence that it is involved in the biological process</span>: histone deacetylation; regulation of transcription. 10 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG6170-PB translation from_gene[CG6170 HDAC6 FBgn0026428] seq_release:3 mol_weight=125798 cds_boundaries:(X:15,065,665..15,071,026[+]) aa_length:1135 transcript_info:[CG6170-RB seq_release:3] gene_info:[gene symbol:HDAC6 FBgn0026428 gene_boundaries:(X [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8IR38) CG6170-PB [DrosMelano7227.FASTAC.txt]
  • CG6170-PB, isoform B [Drosophila melanogaster]gi|24642144|ref|NP_727842.1| CG6170-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(15228684..15228707,15229023..15229301,15229383..15229513,15229579..15229762,15230323..15230594,15230648..15232055,15232105..15232737,15232870..15232957,15233660..15234048); ID=FBpp0073827; name=HDAC6-PB; parent=FBgn0026428,FBtr007 [fly-100309-contam.fasta]
  • HDAC6 CG6170-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG6170-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(15228684..15228707,15229023..15229301,15229383..15229513,15229579..15229762,15230323..15230594,15230648..15232055,15232105..15232737,15232870..15232957,15233660..15234048); ID=FBpp0073827; name=HDAC6-PB; parent=FBgn0026428,FBtr0074010; dbxref=FlyBase:FBpp0073827,FlyBase_Annotation_IDs:CG6170-PB,GB_protein:AAN09661.1,REFSEQ:NP_727842,GB_protein:AAN09661; MD5=c3389620b8f0c072ee5020702ef13cc0; length=1135; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(15228684..15228707,15229023..15229301,15229383..15229513,15229579..15229762,15230323..15230594,15230648..15232055,15232105..15232737,15232870..15232957,15233660..15234048); ID=FBpp0073827; name=HDAC6-PB; parent=FBgn0026428,FBtr0074010; dbxref=FlyBase:FBpp0073827,FlyBase_Annotation_IDs:CG6170-PB,GB_protein:AAN09661.1,REFSEQ:NP_727842,GB_protein:AAN09661; MD5=c3389620b8f0c072ee5020702ef13cc0; length=1135; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • HDAC6, isoform B OS=Drosophila melanogaster GN=HDAC6 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(15228684..15228707,15229023..15229301,15229383..15229513,15229579..15229762,15230323..15230594,15230648..15232055,15232105..15232737,15232870..15232957,15233660..15234048); ID=FBpp0073827; name=HDAC6-PB; parent=FBgn0026428,FBtr0074010; dbxref=FlyBase:FBpp0073827,FlyBase_Annotation_IDs:CG6170-PB,GB_protein:AAN09661.1,REFSEQ:NP_727842,GB_protein:AAN09661,FlyMine:FBpp0073827,modMine:FBpp0073827; MD5=c3389620b8f0c072ee5020702ef13cc0; length=1135; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:join(15334651..15334674,15334990..15335268,15335350..15335480,15335546..15335729,15336290..15336561,15336615..15338022,15338072..15338704,15338837..15338924,15339627..15340015); ID=FBpp0073827; name=HDAC6-PB; parent=FBgn0026428,FBtr0074010; dbxref=FlyBase:FBpp0073827,FlyBase_Annotation_IDs:CG6170-PB,GB_protein:AAN09661.1,REFSEQ:NP_727842,GB_protein:AAN09661,FlyMine:FBpp0073827,modMine:FBpp0073827; MD5=c3389620b8f0c072ee5020702ef13cc0; length=1135; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(15334651..15334674,15334990..15335268,15335350..15335480,15335546..15335729,15336290..15336561,15336615..15338022,15338072..15338704,15338837..15338924,15339627..15340015); ID=FBpp0073827; name=HDAC6-PB; parent=FBgn0026428,FBtr0074010; dbxref=FlyBase:FBpp0073827,FlyBase_Annotation_IDs:CG6170-PB,GB_protein:AAN09661.1,REFSEQ:NP_727842,GB_protein:AAN09661,FlyMine:FBpp0073827,modMine:FBpp0073827; MD5=c3389620b8f0c072ee5020702ef13cc0; length=1135; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of M9PJN5, Histone deacetylase 6 isoform B OS=Drosophila melanogaster GN=HDAC6 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0073827 type=protein; loc=X:join(15334651..15334674,15334990..15335268,15335350..15335480,15335546..15335729,15336290..15336561,15336615..15338022,15338072..15338704,15338837..15338924,15339627..15340015); ID=FBpp0073827; name=HDAC6-PB; parent=FBgn0026428,FBtr0074010; dbxref=FlyBase:FBpp0073827,FlyBase_Annotation_IDs:CG6170-PB,GB_protein:AAN09661.1,REFSEQ:NP_727842,GB_protein:AAN09661,FlyMine:FBpp0073827,modMine:FBpp0073827; MD5=c3389620b8f0c072ee5020702ef13cc0; length=1135; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(15334651..15334674,15334990..15335268,15335350..15335480,15335546..15335729,15336290..15336561,15336615..15338022,15338072..15338704,15338837..15338924,15339627..15340015); ID=FBpp0073827; name=HDAC6-PB; parent=FBgn0026428,FBtr0074010; dbxref=FlyBase:FBpp0073827,FlyBase_Annotation_IDs:CG6170-PB,GB_protein:AAN09661.1,REFSEQ:NP_727842,GB_protein:AAN09661,UniProt/TrEMBL:Q8IR38,FlyMine:FBpp0073827,modMine:FBpp0073827; MD5=c3389620b8f0c072ee5020702ef13cc0; length=1135; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1135 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA]
    Biological Process: histone deacetylation [IDA]
    regulation of transcription [IDA]
    Molecular Function: zinc ion binding [IEA]
    histone deacetylase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRDIWIQSP PIVTRRSAQQ AKIQTRAMAS KSKTGTTGAA TAAGGTGSSS GSISGGFNAA  60
   61 DPRKSNKPNA ALLEAKRRAR NNMLKNQGCG SQESVTDIFQ NAVNSKSLVR KPTALIYDES 120
  121 MSQHCCLWDK EHYECPERFT RVLERCRELN LTERCLELPS RSATKDEILR LHTEEHFERL 180
  181 KETSGIRDDE RMEELSSRYD SIYIHPSTFE LSLLASGSTI ELVDHLVAGK AQNGMAIIRP 240
  241 PGHHAMKAEY NGYCFFNNVA LATQHALDVH KLQRILIIDY DVHHGQGTQR FFYNDPRVVY 300
  301 FSIHRFEHGS FWPHLHESDY HAIGSGAGTG YNFNVPLNAT GMTNGDYLAI FQQLLLPVAL 360
  361 EFQPELIIVS AGYDAALGCP EGEMEVTPAC YPHLLNPLLR LADARVAVVL EGGYCLDSLA 420
  421 EGAALTLRSL LGDPCPPLVE TVPLPRAELA QALLSCIAVH RPHWRCLQLQ QTYDCVELQD 480
  481 RDKEEDLHTV LRHWIGGPPP MDRYPTRDTA IPLPPEKLTS NAARLQVLRA ETKLSVPSFK 540
  541 VCYAYDAQML LHCNLNDTGH PEQPSRIQHI HKMHDDYGLL KQMKQLSPRA ATTDEVCLAH 600
  601 TRAHVNTVRR LLGREPKELH DAAGIYNSVY LHPRTFDCAT LAAGLVLQAV DSVLRGESRS 660
  661 GICNVRPPGH HAEQDHPHGF CIFNNVAIAA QYAIRDFGLE RVLIVDWDVH HGNGTQHIFE 720
  721 SNPKVLYISL HRYEHGSFFP KGPDGNFDVV GKGAGRGFNV NIPWNKKGMG DLEYALAFQQ 780
  781 LIMPIAYEFN PQLVLVSAGF DAAIGDPLGG CKVTAEGYGM LTHWLSALAS GRIIVCLEGG 840
  841 YNVNSISYAM TMCTKTLLGD PVPTPQLGAT ALQKPPTVAF QSCVESLQQC LQVQRNHWRS 900
  901 LEFVGRRLPR DPVVGENNNE DFLTASLRHL NISNDDATAA AGGLAGDRPD CGDERPSGSK 960
  961 PKVKVKTLSD YLAENKEALE QSEMFAVYPL KTCPHLRLLR PEEAPRSLDS GAECSVCGST1020
 1021 GENWVCLSCR HVACGRYVNA HMEQHSVEEQ HPLAMSTADL SVWCYACSAY VDHPRLYAYL1080
 1081 NPLHEDKFQE PMAWTHGCAW REDGCYATGP DGRDEDDDDD NGAGSSICLR LERNN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] deduced N/A No confident structure predictions are available.
    2 View Details [94..476] PSI-BLAST 107.0 No description for 2nvrA was found.
    3 View Details [477..917] FFAS03 8.35 No description for 2nvrA was found.
    4 View Details [918..987] deduced N/A No confident structure predictions are available.
    5 View Details [988..1135] PSI-BLAST 22.0 No description for 2g43A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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