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Protein Overview: FBpp0305524, HDA...

General Information:
Name(s) found: FBpp0305524 [FlyBase]
HDAC4-PB / FBpp0073629 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • type=protein; loc=X:complement(13159015..13159069,13159163..13159296,13159366..13159800,13159871..13159990,13160073..13161287,13161355..13162295,13162727..13162873,13163861..13163991,13164280..13164353,13164424..13164675,13165515..13165556); ID=FBpp0305524; name=HDAC4-PH; parent=FBgn0041210,FBtr0333332; dbxref=REFSEQ:NP_001259508,GB_protein:AGB95350,FlyBase:FBpp0305524,FlyBase_Annotation_IDs:CG1770-PH; MD5=6c5f057b8ff335a337cb0407ff99c960; length=1181; release=r5.56; species=Dmel; [FlyBase]
  • The gene HDAC4 is referred to in FlyBase by the symbol Dmel\HDAC4 (CG1770, FBgn0041210). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13156922..13179354. It has the cytological map location 11E8-11E9. There is experimental evidence that it has the molecular function</span>: histone deacetylase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of transcription. 22 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1181 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    histone deacetylase complex [IEA]
    Biological Process: chromatin modification [IEA]
    regulation of transcription [IDA]
    Molecular Function: histone deacetylase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELEHKLQLE HKYQFAVNSH GAFQELRNES MVTAAAAAVA QEQHRQQLHQ QQQQHQQQQQ  60
   61 QQQHQQQQQQ QQARGRDGMK LKQNCSANAS PEVKQILNCF ILSRKSQAAA SNGTTTTSPY 120
  121 RNRGVVKSSS GESLPAGTVT SAHPYKIPQP PPSLLKYESD FPLRKTASEP NLLKIRLKQS 180
  181 VIERKARIGG PAGARRHERL LQAAQRRQQK NSVLTNCNST PDSGPNSPPS AAALAVGVVG 240
  241 SRGSPTSAPI QEENEEGSQY QPGQRSSIND LPLFSSPSLP NISLGRPHLP NSAQAHAQVN 300
  301 AQVAAQAQAQ AQAQAQAHAM FAALAAAQGG CGQPGYYNPL GMAFVGRQPA PLAMIPATGI 360
  361 APQQPSPVVR SASATSTSSS QASLVGDVAP PQAHAASTIL PSSSSYMQQL GSVAGSGVNL 420
  421 HAAAVAAAAA AAAAAGSLPP TNSHGHGHGS HAHPHPHAHG HGHGHGHGIY AGHQHNVPIT 480
  481 DAQVAQVHLH KQGHRPLGRT QSAPLPLGHP MLTGAVQLNV VQTHYENSEA ERQAYEHQVV 540
  541 NQKVRQTVLT RSGAAAAAAA AAGVSVVREA QLKEEDDDSA AEVMDLTDKK KPPKTVLTST 600
  601 IATSTSQNLP EALAAAAAAA AYRAPHNASS NSASATKSGI KLRDQEYLQQ QREQLLLLQQ 660
  661 EEELAKSLMR PLSRTLSSPL VPLGPHGLSQ IPDTGQQPAP IATSSSADHI PPVNLSLPHR 720
  721 QHRQLMSTLY ASQLRNHQPS ASGSPPHKVT TGLAYDPLML KHSCICGDNA QHPEHSGRLQ 780
  781 SVWARLNETD LVKRCDRLRA RKATQEELQT VHTEAHAMLF GSNQCQLSRP KLENTLSASF 840
  841 VRLSCGGLGV DLDTTWNEHH TATAARMAAG CVIDLALKTA KGDLRNGFAV VRPPGHHAEA 900
  901 NLAMGFCFFN SIAIAAKLLR QRMPEVRRIL IVDWDVHHGN GTQQAFYQSP DILYLSIHRH 960
  961 DDGNFFPGTG GPTECGSGAG LGFNVNISWS GALNPPLGDA EYIAAFRTVV MPIARSFNPD1020
 1021 IVLVSSGFDA ATGHPAPLGG YHVSPACFGF MTRELLQLAN GKVVLALEGG YDLAAICDSA1080
 1081 QECVRALLGD PAAPIAKAEL ERPPCQNAIN TLQKTIAIQQ THWPCVRMLE HTVGLSALET1140
 1141 LKVEHDESET INAMAGLSMQ SMHRTLSRDD SEEPMDQDET K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] deduced N/A No confident structure predictions are available.
    2 View Details [114..291] MSA 2.291996 View MSA. No confident structure predictions are available.
    3 View Details [292..588] MSA 3.305997 View MSA. No confident structure predictions are available.
    4 View Details [589..746] deduced N/A No confident structure predictions are available.
    5 View Details [747..1181] PSI-BLAST 120.0 No description for 2pqoA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.70

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle