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Protein Overview: comt-PA, FBpp0305521

General Information:
Name(s) found: FBpp0305521 [FlyBase]
comt-PA / FBpp0073585 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=X:join(13153279..13153287,13153369..13153457,13153536..13153754,13153828..13155456,13155538..13155696,13155765..13155897); ID=FBpp0305521; name=comt-PB; parent=FBgn0000346,FBtr0333329; dbxref=REFSEQ:NP_001259506,GB_protein:AGB95348,FlyBase:FBpp0305521,FlyBase_Annotation_IDs:CG1618-PB; MD5=1cebd2856ff208f54f5f9da651db31e4; length=745; release=r5.56; species=Dmel; [FlyBase]
  • The gene comatose is referred to in FlyBase by the symbol Dmel\comt (CG1618, FBgn0000346). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13153028..13156527. It has the cytological map location 11E8. It is reported to have molecular function</span>: ATPase activity. There is experimental evidence that it is involved in the biological process</span>: Golgi organization; phagocytosis, engulfment. 34 alleles are reported. The phenotypes of these alleles are annotated with: Golgi stack; retina; Golgi apparatus; central nervous system; NMJ bouton; synapse; embryonic/larval heart. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 745 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISS][NAS]
    Biological Process: ER to Golgi vesicle-mediated transport [NAS]
    synaptic vesicle priming [NAS]
    phagocytosis, engulfment [IMP]
    Golgi organization [IMP]
    neurotransmitter secretion [NAS]
    Molecular Function: ATPase activity [TAS]
    ATP binding [IEA]
    nucleoside-triphosphatase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYILKATKC PTDELSLTNR AIVNVGDFPE EIKYADISPA PGQHFIFALE KTVEVPSGYV  60
   61 GFSLVQRKWA MVSINQELEV RPYRFDASSD VITCVSFETD FLQKKTVSQE PYDSDQMAKE 120
  121 FIMQFAGMAL TVGQSLVFNF KDKKLLGLAV KSLEAIDPKS LGEGKDTAMR NVRFGRILGN 180
  181 TVVQFEKAEN SSLNLQGKSK GKVVRQSIIN PDWDFGKMGI GGLDKEFNSI FRRAFASRVF 240
  241 PPELVEQLGC KHVKGILLYG PPGTGKTLMA RQIGTMLNAR EPKIVNGPQI LDKYVGESEA 300
  301 NVRRLFAEAE EEEKRLGPNS GLHIIIFDEI DAICKQRGSV AGNSGVHDTV VNQLLTKIDG 360
  361 VDQLNNILVI GMTNRRDMID EALLRPGRLE VQMEISLPNE QGRVQILNIH TKRMREFNKI 420
  421 NDDVDNKEIA ALTKNFSGAE LEGLVRAAQS SAMNRLIKAD AKVTVDPEAM EKLKVNRDDF 480
  481 LHSLEHDIKP AFGTAQEILD NMLARGVINW GAPVSNLLED GMLYVQQAKA PESSGLVSVL 540
  541 VAGAPNSGKT ALAAQLAKMS DFPFVKVCSP EDMVGYTESA KCLHIRKIFD DAYRSMLSCI 600
  601 VVDNVERLLD YGSIGPRYSN MTLQALLVLL KKQPPKGRKL LILCTSSRRE VLEEMEMLTA 660
  661 FTSVLHVPNL SKPDHVLAVL ENTDIFSKGE IQAIGKKMAG KRVFIGIKKL LGLIDMARQT 720
  721 EQSQRAIKFL SKMEEEGGLD MVARQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..745] PSI-BLAST 130.0 VCP/p97


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle