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Protein Overview: Fer3HCH-PA

General Information:
Name(s) found: Fer3HCH-PA / FBpp0073576 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Ferritin 3 heavy chain homologue is referred to in FlyBase by the symbol Dmel\Fer3HCH (CG4349, FBgn0030449). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13001415..13002227. It has the cytological map location 11D11. Based on sequence similarity, it is predicted to have molecular function</span>: ferrous iron binding. There is experimental evidence that it is involved in the biological process</span>: cellular response to iron ion starvation. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 186 amino acids

    Gene Ontology:
    Cellular Component: intracellular ferritin complex [ISS]
    Biological Process: cellular iron ion homeostasis [ISS]
    iron ion transport [IEA]
    oxidation reduction [IEA]
    cellular response to iron ion starvation [IMP]
    Molecular Function: ferric iron binding [IEA]
    ferrous iron binding [ISS]
    oxidoreductase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWCFRDIRR HMCMLVRQNF AKSCEKKLND QINMELKASH QYLAMAYHFD RSDISSPGMH  60
   61 RFFLKASVEE REHAEKIMTY MNKRGGLIIL SSVPQPLPCF ASTLDALKHA MKMELEVNKH 120
  121 LLDLHALAGK EADPNLCDFI EANFLQEQVD GQKILADYIS QLEKAQNQVG EFLFDKYMGS 180
  181 GMHPAK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] PSI-BLAST 56.30103 SOLVING THE STRUCTURE OF HUMAN H FERRITIN BY GENETICALLY ENGINEERING INTERMOLECULAR CRYSTAL CONTACTS

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ferric iron binding
    		•  5.55100638826026 bayes_pls_golite062009
  • iron ion binding
    		•  3.10225782829614 bayes_pls_golite062009
  • binding
    		•  1.95813969002966 bayes_pls_golite062009
  • transition metal ion binding
    		•  1.70242943635222 bayes_pls_golite062009
  • cation binding
    		•  1.66873432300081 bayes_pls_golite062009
  • metal ion binding
    		•  1.66873432300081 bayes_pls_golite062009
  • ion binding
    		•  1.66140448750278 bayes_pls_golite062009
  • ribonucleoside-diphosphate reductase activity
    		•  0.366005079572569 bayes_pls_golite062009
  • protein binding
    		•  0.30514049100341 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
    		•  0.289628933165632 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle