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Protein Overview: tomosyn-PF, tomo...

General Information:
Name(s) found: FBpp0300333 [FlyBase]
tomosyn-PF / FBpp0289604 [FlyBase]
tomosyn-PC / FBpp0073511 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • type=protein; loc=X:join(12530194..12530316,12530572..12530669,12530744..12530932,12531084..12531218,12531294..12531357,12531471..12531678,12531740..12531815,12532052..12532206,12532377..12532558,12532626..12533108,12533187..12533329,12534695..12534872,12537906..12538800,12545143..12545259,12545328..12545450,12545512..12545631,12545708..12546157,12546274..12546382,12546448..12546534,12546602..12546697,12546772..12546896,12546980..12547236); ID=FBpp0300333; name=Tomosyn-PI; parent=FBgn0030412,FBtr0307899; dbxref=REFSEQ:NP_727628,GB_protein:AAF48190,FlyBase:FBpp0300333,FlyBase_Annotation_IDs:CG17762-PI; MD5=e68c615347a9b1fbd880d4f1d88cccf3; length=1470; release=r5.56; species=Dmel; [FlyBase]
  • The gene tomosyn is referred to in FlyBase by the symbol Dmel\tomosyn (CG17762, FBgn0030412). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12525653..12547377. It has the cytological map location 11B6-11B7. Based on sequence similarity, it is predicted to have molecular function</span>: syntaxin-1 binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: synaptic vesicle exocytosis. 8 alleles are reported. The phenotype of these alleles is annotated with: intersegmental nerve. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene tomosyn is referred to in FlyBase by the symbol Dmel\tomosyn (CG17762, FBgn0030412). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12525653..12547377. It has the cytological map location 11B6-11B7. Based on sequence similarity, it is predicted to have molecular function</span>: syntaxin-1 binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: synaptic vesicle exocytosis. 8 alleles are reported. The phenotype of these alleles is annotated with: intersegmental nerve. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1470 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [NAS]
    integral to membrane [IEA]
    Biological Process: synaptic vesicle priming [NAS]
    vesicle-mediated transport [IEA]
    establishment or maintenance of cell polarity [NAS]
    synaptic vesicle exocytosis [ISS]
    neurotransmitter secretion [NAS]
    Molecular Function: syntaxin-1 binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKFTFKGVL DGFRQSVQPQ ATRQEQEIQE QLKADHFTLK KTFRHGFPYS PTSFAFDPVQ  60
   61 KLLAIGDKSG YIRILGRPGV DAHAKHEGES ECAVLFAQFL VNEGALVTVT ADDTIHLWSI 120
  121 RQKTPRIVQS LKFQRERVTC IHLPVGSKWL YVGTEKGNIH VVHIDTFALS GYIINWNKAI 180
  181 EVVRTSHPGA VIALCDNPLD ANKLLIAFEC GLLVLWDLKA KCAELRWQAA EAVKSLAWHY 240
  241 EGKYFVSSHT DGSICSWPTK PQAKPQSQVC PHAKINKDGN AEKCKPIYKV DLKSSATGET 300
  301 FTIFSGGMPS EKGSKSNCIT VMVGKATTVL EMEHAVCDFI TLCENPWPCE TQEPYAIAVL 360
  361 LQYDLVLIDL LTPGFPCFES PYPMDLHESP VTCCTYLTDC PSDLVPAFYS VGRTTTSKKS 420
  421 CFSEREWPIS GGEWSPASCS YSEIVITGHQ DGSLKFWDSG AGTLQILYKL KTAKMFEKPR 480
  481 SHVAHSHPES DNPLAVHLIF LCSESRRLCV AGAMGQVMLF KFRKVESTSE VLVLEIPILY 540
  541 ENFDDIYGTS PECDFLTGHQ VQKAESSDSD KTAECSLKVR NGAQRKPPGF QSQLVCLTTG 600
  601 PNRRNVQVTS LCISSSYGLM AYGTEYGLVI IDIIQKICLL SVACPDLYGA HDPYSRTPKS 660
  661 PKRIENKEEQ SRSPSSDQLN DTTSPDSPSL EFVPEAGETS AHDGVATATS SRPSSPDPVV 720
  721 NSARETLLSG SAAATAAAAA SAAVMMAKSP QRDDAAPKEL QDRRKSMSWK TFNLKRQLSK 780
  781 VNMKIGGLNV NTDMESLKNS SIFYTPKEVS PEAATPPATE EEATPEGKED ESLDDGEMAT 840
  841 NAGAAAAASP SPAVRGKFRS STTDSPDEGA SSSIASGIRR VDFEQPAGVE VERPNNLPLA 900
  901 DAPAPLKPAR QKFKEKSRDQ RLLSVPNIKY QPRDSRGGAR NLKNDVSPLM GGGGGGGGVV 960
  961 GASSGIGGSV AGGKKIHKLD GTFSRSRSSS MSSIDMSSSE SVTCLAFIES YAKRNDILTL1020
 1021 VPTLWIGTSF GSILTLFITM PERDVRKSQP VLITINGGPV VRLKGSITSM SFLDSYGSII1080
 1081 PYTFETWRDE KRDNKDRTPT KSSSRTSPTF TPTTANTLSN TSVAGGASAG GGAGGGGGAG1140
 1141 GGAASGGAAA GGPAGGGAGA GSAAGAAGGV GSGVTSGGGM SSSSASSSGI SGSVSTGLET1200
 1201 LTDRQYIVIA SEKQTKVFDV ANQCCINRIQ LSEMDFAVKA ETITMKDGSC LATYLSNGHL1260
 1261 MVHSLPSLKL LLDTDFLPLM ELSFQTKCKQ GIVDPMLSIW GQQIIVHEDT TQISKIFCFS1320
 1321 HKGHGLYMAS PTEIQKFTIS SEFCQFILEM MGELYTVHEM PEQPKEGFFK GLFGGGAKLL1380
 1381 DREELFGEQS GKPNRSVARH IPGPNLEQLG QRASTAASEI SRAHQLAMER GEKLNLLEER1440
 1441 AERMANTAQD FSGTAHQLML KYKDKKWYQL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..549] PSI-BLAST 46.69897 Actin interacting protein 1
    2 View Details [550..712] deduced N/A No confident structure predictions are available.
    3 View Details [713..831] deduced N/A No confident structure predictions are available.
    4 View Details [832..985] deduced N/A No confident structure predictions are available.
    5 View Details [986..1133] deduced N/A No confident structure predictions are available.
    6 View Details [1134..1288] deduced N/A No confident structure predictions are available.
    7 View Details [1289..1407] deduced N/A No confident structure predictions are available.
    8 View Details [1408..1470] PSI-BLAST 18.69897 Crystal structure of neuronal Q-SNAREs in complex with R-SNARE motif of Tomosyn

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.79788997337153 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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