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View Structure Prediction Details

Protein: tomosyn-PF, tomo...
Organism: Drosophila melanogaster
Length: 1470 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tomosyn-PF, tomo....

Description E-value Query
Range
Subject
Range
gi|7505846 - gi|7505846|pir||T25828 hypothetical protein M01A10.2a - Caenorhabditis elegans
674.0 [0..11] [1470..20]

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Predicted Domain #1
Region A:
Residues: [1-549]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKFTFKGVL DGFRQSVQPQ ATRQEQEIQE QLKADHFTLK KTFRHGFPYS PTSFAFDPVQ  60
   61 KLLAIGDKSG YIRILGRPGV DAHAKHEGES ECAVLFAQFL VNEGALVTVT ADDTIHLWSI 120
  121 RQKTPRIVQS LKFQRERVTC IHLPVGSKWL YVGTEKGNIH VVHIDTFALS GYIINWNKAI 180
  181 EVVRTSHPGA VIALCDNPLD ANKLLIAFEC GLLVLWDLKA KCAELRWQAA EAVKSLAWHY 240
  241 EGKYFVSSHT DGSICSWPTK PQAKPQSQVC PHAKINKDGN AEKCKPIYKV DLKSSATGET 300
  301 FTIFSGGMPS EKGSKSNCIT VMVGKATTVL EMEHAVCDFI TLCENPWPCE TQEPYAIAVL 360
  361 LQYDLVLIDL LTPGFPCFES PYPMDLHESP VTCCTYLTDC PSDLVPAFYS VGRTTTSKKS 420
  421 CFSEREWPIS GGEWSPASCS YSEIVITGHQ DGSLKFWDSG AGTLQILYKL KTAKMFEKPR 480
  481 SHVAHSHPES DNPLAVHLIF LCSESRRLCV AGAMGQVMLF KFRKVESTSE VLVLEIPILY 540
  541 ENFDDIYGT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.69897
Match: 1nr0A
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.79788997337153 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [550-712]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPECDFLTGH QVQKAESSDS DKTAECSLKV RNGAQRKPPG FQSQLVCLTT GPNRRNVQVT  60
   61 SLCISSSYGL MAYGTEYGLV IIDIIQKICL LSVACPDLYG AHDPYSRTPK SPKRIENKEE 120
  121 QSRSPSSDQL NDTTSPDSPS LEFVPEAGET SAHDGVATAT SSR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [713-831]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSPDPVVNS ARETLLSGSA AATAAAAASA AVMMAKSPQR DDAAPKELQD RRKSMSWKTF  60
   61 NLKRQLSKVN MKIGGLNVNT DMESLKNSSI FYTPKEVSPE AATPPATEEE ATPEGKEDE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [832-985]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDDGEMATN AGAAAAASPS PAVRGKFRSS TTDSPDEGAS SSIASGIRRV DFEQPAGVEV  60
   61 ERPNNLPLAD APAPLKPARQ KFKEKSRDQR LLSVPNIKYQ PRDSRGGARN LKNDVSPLMG 120
  121 GGGGGGGVVG ASSGIGGSVA GGKKIHKLDG TFSR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [986-1133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRSSSMSSID MSSSESVTCL AFIESYAKRN DILTLVPTLW IGTSFGSILT LFITMPERDV  60
   61 RKSQPVLITI NGGPVVRLKG SITSMSFLDS YGSIIPYTFE TWRDEKRDNK DRTPTKSSSR 120
  121 TSPTFTPTTA NTLSNTSVAG GASAGGGA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1134-1288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGGGAGGGA ASGGAAAGGP AGGGAGAGSA AGAAGGVGSG VTSGGGMSSS SASSSGISGS  60
   61 VSTGLETLTD RQYIVIASEK QTKVFDVANQ CCINRIQLSE MDFAVKAETI TMKDGSCLAT 120
  121 YLSNGHLMVH SLPSLKLLLD TDFLPLMELS FQTKC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1289-1407]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQGIVDPMLS IWGQQIIVHE DTTQISKIFC FSHKGHGLYM ASPTEIQKFT ISSEFCQFIL  60
   61 EMMGELYTVH EMPEQPKEGF FKGLFGGGAK LLDREELFGE QSGKPNRSVA RHIPGPNLE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1408-1470]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLGQRASTAA SEISRAHQLA MERGEKLNLL EERAERMANT AQDFSGTAHQ LMLKYKDKKW  60
   61 YQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.69897
Match: 1urqA
Description: Crystal structure of neuronal Q-SNAREs in complex with R-SNARE motif of Tomosyn
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle