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Protein Overview: tomosyn-PA, tomo...

General Information:
Name(s) found: tomosyn-PA / FBpp0073510 [FlyBase]
tomosyn-PB / FBpp0073509 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene tomosyn is referred to in FlyBase by the symbol Dmel\tomosyn (CG17762, FBgn0030412). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12525653..12547377. It has the cytological map location 11B6-11B7. Based on sequence similarity, it is predicted to have molecular function</span>: syntaxin-1 binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: synaptic vesicle exocytosis. 8 alleles are reported. The phenotype of these alleles is annotated with: intersegmental nerve. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene tomosyn is referred to in FlyBase by the symbol Dmel\tomosyn (CG17762, FBgn0030412). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12525653..12547377. It has the cytological map location 11B6-11B7. Based on sequence similarity, it is predicted to have molecular function</span>: syntaxin-1 binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: synaptic vesicle exocytosis. 8 alleles are reported. The phenotype of these alleles is annotated with: intersegmental nerve. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1173 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [NAS]
    integral to membrane [IEA]
    Biological Process: synaptic vesicle priming [NAS]
    vesicle-mediated transport [IEA]
    establishment or maintenance of cell polarity [NAS]
    synaptic vesicle exocytosis [ISS]
    neurotransmitter secretion [NAS]
    Molecular Function: syntaxin-1 binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKFTFKGVL DGFRQSVQPQ ATRQEQEIQE QLKADHFTLK KTFRHGFPYS PTSFAFDPVQ  60
   61 KLLAIGDKSG YIRILGRPGV DAHAKHEGES ECAVLFAQFL VNEGALVTVT ADDTIHLWSI 120
  121 RQKTPRIVQS LKFQRERVTC IHLPVGSKWL YVGTEKGNIH VVHIDTFALS GYIINWNKAI 180
  181 EVVRTSHPGA VIALCDNPLD ANKLLIAFEC GLLVLWDLKA KCAELRWQAA EAVKSLAWHY 240
  241 EGKYFVSSHT DGSICSWPTK PQAKPQSQVC PHAKINKDGN AEKCKPIYKV DLKSSATGET 300
  301 FTIFSGGMPS EKGSKSNCIT VMVGKATTVL EMEHAVCDFI TLCENPWPCE TQEPYAIAVL 360
  361 LQYDLVLIDL LTPGFPCFES PYPMDLHESP VTCCTYLTDC PSDLVPAFYS VGRTTTSKKS 420
  421 CFSEREWPIS GGEWSPASCS YSEIVITGHQ DGSLKFWDSG AGTLQILYKL KTAKMFEKPR 480
  481 SHVAHSHPES DNPLAVHLIF LCSESRRLCV AGAMGQVMLF KFRKVESTSE VLVLEIPILY 540
  541 ENFDDIYGTS PECDFLTGHQ VQKAESSDSD KTAECSLKVR NGAQRKPPGF QSQLVCLTTG 600
  601 PNRRNVQVTS LCISSSYGLM AYGTEYGLVI IDIIQKICLL SVACPDLYGA HDPYSRTPKS 660
  661 PKRIENKEEQ SRSPSSDQVN KLDGTFSRSR SSSMSSIDMS SSESVTCLAF IESYAKRNDI 720
  721 LTLVPTLWIG TSFGSILTLF ITMPERDVRK SQPVLITING GPVVRLKGSI TSMSFLDSYG 780
  781 SIIPYTFETW RDEKRDNKDR TPTKSSSRTS PTFTPTTANT LSNTSVAGGA SAGGGAGGGG 840
  841 GAGGGAASGG AAAGGPAGGG AGAGSAAGAA GGVGSGVTSG GGMSSSSASS SGISGSVSTG 900
  901 LETLTDRQYI VIASEKQTKV FDVANQCCIN RIQLSEMDFA VKAETITMKD GSCLATYLSN 960
  961 GHLMVHSLPS LKLLLDTDFL PLMELSFQTK CKQGIVDPML SIWGQQIIVH EDTTQISKIF1020
 1021 CFSHKGHGLY MASPTEIQKF TISSEFCQFI LEMMGELYTV HEMPEQPKEG FFKGLFGGGA1080
 1081 KLLDREELFG EQSGKPNRSV ARHIPGPNLE QLGQRASTAA SEISRAHQLA MERGEKLNLL1140
 1141 EERAERMANT AQDFSGTAHQ LMLKYKDKKW YQL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] PSI-BLAST 72.69897 PAF-AH Holoenzyme: Lis1/Alfa2
    2 View Details [77..415] PSI-BLAST 6.522879 Surface layer protein
    3 View Details [416..625] PSI-BLAST 14.522879 Crystal Structure analysis of the beta-propeller protein Ski8p
    4 View Details [626..716] deduced N/A No confident structure predictions are available.
    5 View Details [717..937] FFAS03 0.97 Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.
    6 View Details [938..1097] deduced N/A No confident structure predictions are available.
    7 View Details [1098..1173] PSI-BLAST 19.09691 Crystal structure of neuronal Q-SNAREs in complex with R-SNARE motif of Tomosyn

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.66964148100475 bayes_pls_golite062009
  • protein binding
    		•  0.931624635835922 bayes_pls_golite062009
  • transporter activity
    		•  0.711149297585691 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.517650155593165 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.276105437109391 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.113736784801445 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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