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Protein Overview: Met-PA, FBpp0310182

General Information:
Name(s) found: FBpp0310182 [FlyBase]
Met-PA / FBpp0073368 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • type=protein; loc=X:join(11510901..11512193,11512263..11513120); ID=FBpp0310182; name=Met-PB; parent=FBgn0002723,FBtr0343585; dbxref=FlyBase:FBpp0310182,FlyBase_Annotation_IDs:CG1705-PB; MD5=bcf1826f56e98b28c59bc52d969b5bd8; length=716; release=r5.56; species=Dmel; [FlyBase]
  • The gene Methoprene-tolerant is referred to in FlyBase by the symbol Dmel\Met (CG1705, FBgn0002723). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11510901..11513120. It has the cytological map location 10D1. There is experimental evidence that it has the molecular function</span>: transcription regulator activity; protein heterodimerization activity; juvenile hormone binding; protein homodimerization activity. There is experimental evidence that it is involved in the biological process</span>: regulation of transcription; regulation of developmental process. 22 alleles are reported. The phenotypes of these alleles are annotated with: stage S13 oocyte; stage S10 oocyte; stage S8 oocyte; stage S11 oocyte; ovary; stage S14 oocyte; stage S9 oocyte; stage S12 oocyte. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 716 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][TAS]
    Biological Process: regulation of developmental process [IMP]
    signal transduction [IEA]
    regulation of transcription, DNA-dependent [IEA]
    regulation of transcription [IDA][IEA][TAS]
    Molecular Function: transcription factor activity [ISS]
    protein homodimerization activity [IDA]
    transcription regulator activity [IDA]
    protein heterodimerization activity [IDA]
    signal transducer activity [IEA]
    juvenile hormone binding [IDA][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPETGNTG STGSAGSTGS GSGSGSGSGS SSDPANGREA RNLAEKQRRD KLNASIQELA  60
   61 TMVPHAAESS RRLDKTAVLR FATHGLRLQY VFGKSASRRR KKTGLKGTGM SASPVGDLPN 120
  121 PSLHLTDTLM QLLDCCFLTL TCSGQIVLVS TSVEQLLGHC QSDLYGQNLL QITHPDDQDL 180
  181 LRQQLIPRDI ETLFYQHQHH QQQGHNPQQH STSTSASTSG SDLEEEEMET EEHRLGRQQG 240
  241 EADDDEDHPY NRRTPSPRRM AHLATIDDRL RMDRRCFTVR LARASTRAEA TRHYERVKID 300
  301 GCFRRSDSSL TGGAAANYPI VSQLIRRSRN NNMLAAAAAV AAEAATVPPQ HDAIAQAALH 360
  361 GISGNDIVLV AMARVLREER PPEETEGTVG LTIYRQPEPY QLEYHTRHLI DGSIIDCDQR 420
  421 IGLVAGYMKD EVRNLSPFCF MHLDDVRWVI VALRQMYDCN SDYGESCYRL LSRNGRFIYL 480
  481 HTKGFLEVDR GSNKVHSFLC VNTLLDEEAG RQKVQEMKEK FSTIIKAEMP TQSSSPDLPA 540
  541 SQAPQQLERI VLYLIENLQK SVDSAETVGG QGMESLMDDG YSSPANTLTL EELAPSPTPA 600
  601 LALVPPAPSS VKSSISKSVS VVNVTAARKF QQEHQKQRER DREQLKERTN STQGVIRQLS 660
  661 SCLSEAETAS CILSPASSLS ASEAPDTPDP HSNTSPPPSL HTRPSVLHRT LTSTLR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118] PSI-BLAST 7.69897 SREBP-1a
    2 View Details [119..244] FFAS03 5.23 Histidine kinase FixL heme domain
    3 View Details [245..607] PSI-BLAST 48.69897 Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
    4 View Details [608..716] MSA 3.265997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.75270293029792 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • transcription activator activity
    		•  2.5495467409976 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.48787404513864 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.31910036997977 bayes_pls_golite062009
  • protein binding
    		•  1.59929864805879 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  1.46304579811572 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.801830750183111 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.27604928641749 bayes_pls_golite062009
  • DNA binding
    		•  3.83861939247274 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.43738039086015 bayes_pls_golite062009
  • transcription factor activity
    		•  3.18442852449976 bayes_pls_golite062009
  • binding
    		•  3.0194696248926 bayes_pls_golite062009
  • transcription factor binding
    		•  2.22314179303094 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.13819142609078 bayes_pls_golite062009
  • transcription activator activity
    		•  1.8593473738006 bayes_pls_golite062009
  • protein binding
    		•  1.60673447924806 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.54935001412565 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.06445298547053 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.934727986222767 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.865848090169615 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.614755150740891 bayes_pls_golite062009
  • histone acetyltransferase binding
    		•  0.609670492126344 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.3832620238984 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.119454387636252 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.104316215089923 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle