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Protein Overview: Rph-PA

General Information:
Name(s) found: Rph-PA / FBpp0071431 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Rabphilin is referred to in FlyBase by the symbol Dmel\Rph (CG11556, FBgn0030230). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10643110..10651699. It has the cytological map location 9E2-9E4. Based on sequence similarity, it is predicted to have molecular function</span>: protein transporter activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: synaptic vesicle exocytosis; synaptic vesicle endocytosis. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 638 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [IEA][NAS]
    membrane [IEA]
    Biological Process: vesicle-mediated transport [NAS]
    synaptic vesicle endocytosis [ISS]
    synaptic vesicle exocytosis [ISS]
    intracellular protein transport [IEA]
    neurotransmitter secretion [NAS]
    Molecular Function: zinc ion binding [IEA]
    protein transporter activity [ISS]
    Rab GTPase binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFQNRNNTA NKFVCPSDRQ LALRAKLKAG WSSSKTSEPL RPEEQEAIIS VIRRNEEIEV  60
   61 AERQRVGRLV ERVEKIKQHA VERGPNCCRL CGDTFGILRP QRILCEDCRQ SVCTKCSVDI 120
  121 NIRYHTSERS REIWLCRICS ETREMWKKSG AWFFKGLPKY DMPRSASATP IPNPGPGSMA 180
  181 GDTRAVQSCH ATPTRPARVK KLTIRVNDSS SSSSGHSEPE DEVDTGVGIG VGVVGGGMAK 240
  241 GIASTRLQRE DSFRLRAYGS IRSFIDGGER KLSNSFFFNR QQSQRPSECP EYDSVSMSKL 300
  301 RRESSFLRRG SVSSSWSISD SSGSGSNNSG NSQTQSQYQQ HQQQLQQHCR DPLLGWLEIA 360
  361 ISYREAFHSL DCTMVRARDL PAMDAAGLAD PYCKLNIITP EAHTKYTRWQ RTKTVHKTRN 420
  421 PEFNETLQFV GVEPEELGNS LIYVALFDDD KYGHDFLGAA KVCLSTVHST SQYRISVPLG 480
  481 VEDQYSNAAE MAQNWPNGKM LLSLCYNTKR RALVVNVKQC INLMAMDNNG SSDPFVKIQL 540
  541 KPDAHKNKKH KTSVKWRTLN PIYNEEFYFE ASPHDLNKEM LILTVWDKDL GKSNDFLGSL 600
  601 QLGAQSKGER LQQWLDCIRL PDHFHEKWHC LAPDNPAH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] PSI-BLAST 29.522879 Effector domain of rabphilin-3a
    2 View Details [169..337] deduced N/A No confident structure predictions are available.
    3 View Details [338..638] PSI-BLAST 62.0 Synaptogamin I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.30634266891018 bayes_pls_golite062009
  • protein binding
    		•  1.32366404206022 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.14205751938857 bayes_pls_golite062009
  • phospholipid binding
    		•  0.80395524110653 bayes_pls_golite062009
  • phosphatidylinositol binding
    		•  0.41867699028241 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.252619815825555 bayes_pls_golite062009
  • DNA binding
    		•  0.223827909774173 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.107173543930241 bayes_pls_golite062009
  • transporter activity
    		•  0.0727830088566982 bayes_pls_golite062009
  • histone binding
    		•  0.0177836520392798 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle