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Protein Overview: FBpp0305497, flw-PB

General Information:
Name(s) found: FBpp0305497 [FlyBase]
flw-PB / FBpp0071382 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=X:join(10280545..10280596,10300386..10300733,10300795..10301138,10301199..10301333,10301399..10301512); ID=FBpp0305497; name=flw-PC; parent=FBgn0000711,FBtr0333305; dbxref=REFSEQ:NP_001259407,GB_protein:AGB95250,FlyBase:FBpp0305497,FlyBase_Annotation_IDs:CG2096-PC; MD5=98dac36ac6f920877ea2923e5aa8e0b8; length=330; release=r5.56; species=Dmel; [FlyBase]
  • The gene flap wing is referred to in FlyBase by the symbol Dmel\flw (CG2096, FBgn0000711). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:10279966..10302119. It has the cytological map location 9B14-9C1. There is experimental evidence that it has the molecular function</span>: myosin phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: ovarian nurse cell to oocyte transport; striated muscle tissue development; chromosome segregation; ovarian ring canal formation; negative regulation of JNK cascade; imaginal disc-derived wing morphogenesis. 17 alleles are reported. The phenotypes of these alleles are annotated with 27 unique terms, many of which group under: adult segment; adult mesothoracic segment; indirect flight muscle; adult somatic muscle; cytoplasmic part; female germline cyst; cell cycle; external compound sense organ; actin cytoskeleton; contractile fiber; peripheral nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 330 amino acids

    Gene Ontology:
    Cellular Component: protein phosphatase type 1 complex [ISS]
    Biological Process: striated muscle tissue development [IMP]
    protein amino acid dephosphorylation [ISS][NAS]
    mesoderm development [NAS]
    ovarian nurse cell to oocyte transport [IMP]
    imaginal disc-derived wing morphogenesis [IMP]
    female germline ring canal formation [IMP]
    chromosome segregation [IMP]
    cell adhesion [NAS]
    negative regulation of JNK cascade [IGI]
    muscle attachment [NAS]
    instar larval development [NAS]
    Molecular Function: protein serine/threonine phosphatase activity [ISS][NAS]
    myosin phosphatase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDFDLNVDS LIQRLLEMRS CRTGKQVQMT EAEVRGLCLK SREIFLQQPI LLELEAPLII  60
   61 CGDIHGQYTD LLRLFEYGGF PPAANYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL 120
  121 RGNHECASIN RIYGFYDECK RRYNVKLWKT FTDCFNCLPV AAIIDEKIFC CHGGLSPDLQ 180
  181 GMEQIRRLMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGVDV VSKFLNRHEL 240
  241 DLICRAHQVV EDGYEFFARR QLVTLFSAPN YCGEFDNAGG MMTVDDTLMC SFQILKPSEK 300
  301 KAKYLYSGMN SSRPTTPQRS APMLATNKKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..330] PSI-BLAST 105.0 Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.126411744957937 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle