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Protein Overview: ND75-PB, ND75-PA

General Information:
Name(s) found: ND75-PB / FBpp0071129 [FlyBase]
ND75-PA / FBpp0071128 [FlyBase]
Description(s) found:
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  • gi|7290915|gb|AAF46356.1| NADH:ubiquinone reductase 75kD subunit precursor, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|24640559|ref|NP_727255.1| NADH:ubiquinone reductase 75kD subunit precursor, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|24640557|ref|NP_511083.1| NADH:ubiquinone reductase 75kD subunit precursor, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|22831939|gb|AAN09230.1| NADH:ubiquinone reductase 75kD subunit precursor, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|13124802|sp|Q94511.3|NDUS1_DROME RecName: Full=NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; AltName: Full=Complex I-75kD; Short=CI-75kD; Flags: Precursor [NCBI NR]
  • (Q94511) NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-75Kd) (CI-75Kd) [Swiss-Prot]
  • NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Drosophila melanogaster GN=ND-75 PE=2 SV=3 [Swiss-Prot]
  • The gene NADH:ubiquinone reductase 75kD subunit precursor is referred to in FlyBase by the symbol Dmel\ND75 (CG2286, FBgn0017566). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8142684..8145699. It has the cytological map location 7E1. Based on sequence similarity, it is predicted to have molecular function</span>: NADH dehydrogenase activity; NADH dehydrogenase (ubiquinone) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ATP synthesis coupled electron transport. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG2286-PA translation from_gene[CG2286 ND75 FBgn0017566] seq_release:3 mol_weight=78631 cds_boundaries:(X:7,987,879..7,990,329[-]) aa_length:731 transcript_info:[CG2286-RA seq_release:3] gene_info:[gene symbol:ND75 FBgn0017566 gene_boundaries:(X:7,987 [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG2286-PB translation from_gene[CG2286 ND75 FBgn0017566] seq_release:3 mol_weight=78631 cds_boundaries:(X:7,987,879..7,990,329[-]) aa_length:731 transcript_info:[CG2286-RB seq_release:3] gene_info:[gene symbol:ND75 FBgn0017566 gene_boundaries:(X:7,987 [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003443) ND75 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG2286-PB, isoform B [Drosophila melanogaster]gi|7290915|gb|AAF46356.1| CG2286-PA, isoform A [Drosophila melanogaster]gi|24640559|ref|NP_727255.1| CG2286-PB [Drosophila melanogaster]gi|24640557|ref|NP_511083.1| CG2286-PA [Drosophila melanogaster]gi|13 [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(8142963..8143127,8143187..8143675,8143736..8144762,8144831..8145162,8145234..8145416); ID=FBpp0071128; name=ND75-PA; parent=FBgn0017566,FBtr0071180; dbxref=FlyBase:FBpp0071128,FlyBase_Annotation_IDs:CG2286-PA,GB_protein:AAF4 [fly-100309-contam.fasta]
  • type=protein; loc=X:complement(8142963..8143127,8143187..8143675,8143736..8144762,8144831..8145162,8145234..8145416); ID=FBpp0071129; name=ND75-PB; parent=FBgn0017566,FBtr0071181; dbxref=FlyBase:FBpp0071129,FlyBase_Annotation_IDs:CG2286-PB,GB_protein:AAN0 [fly-100309-contam.fasta]
  • NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor (Complex I-75kD) (CI-75kD) [nr-271106-contam.fasta]
  • CG2286-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG2286-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • NADH:ubiquinone reductase 75kD subunit precursor CG2286-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • NADH:ubiquinone reductase 75kD subunit precursor CG2286-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(8142963..8143127,8143187..8143675,8143736..8144762,8144831..8145162,8145234..8145416); ID=FBpp0071128; name=ND75-PA; parent=FBgn0017566,FBtr0071180; dbxref=FlyBase:FBpp0071128,FlyBase_Annotation_IDs:CG2286-PA,GB_protein:AAF46356.1,REFSEQ:NP_511083,GB_protein:AAF46356; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(8142963..8143127,8143187..8143675,8143736..8144762,8144831..8145162,8145234..8145416); ID=FBpp0071129; name=ND75-PB; parent=FBgn0017566,FBtr0071181; dbxref=FlyBase:FBpp0071129,FlyBase_Annotation_IDs:CG2286-PB,GB_protein:AAN09230.1,REFSEQ:NP_727255,GB_protein:AAN09230; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(8142963..8143127,8143187..8143675,8143736..8144762,8144831..8145162,8145234..8145416); ID=FBpp0071128; name=ND75-PA; parent=FBgn0017566,FBtr0071180; dbxref=FlyBase:FBpp0071128,FlyBase_Annotation_IDs:CG2286-PA,GB_protein:AAF46356.1,REFSEQ:NP_511083,GB_protein:AAF46356; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=X:complement(8142963..8143127,8143187..8143675,8143736..8144762,8144831..8145162,8145234..8145416); ID=FBpp0071129; name=ND75-PB; parent=FBgn0017566,FBtr0071181; dbxref=FlyBase:FBpp0071129,FlyBase_Annotation_IDs:CG2286-PB,GB_protein:AAN09230.1,REFSEQ:NP_727255,GB_protein:AAN09230; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Drosophila melanogaster GN=ND75 PE=2 SV=3 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • NADH-ubiquinone oxidoreductase 75 kDa subunit OS=Drosophila melanogaster GN=ND75 PE=3 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:complement(8142963..8143127,8143187..8143675,8143736..8144762,8144831..8145162,8145234..8145416); ID=FBpp0071128; name=ND75-PA; parent=FBgn0017566,FBtr0071180; dbxref=FlyBase:FBpp0071128,FlyBase_Annotation_IDs:CG2286-PA,GB_protein:AAF46356.1,REFSEQ:NP_511083,GB_protein:AAF46356,FlyMine:FBpp0071128,modMine:FBpp0071128; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(8142963..8143127,8143187..8143675,8143736..8144762,8144831..8145162,8145234..8145416); ID=FBpp0071129; name=ND75-PB; parent=FBgn0017566,FBtr0071181; dbxref=FlyBase:FBpp0071129,FlyBase_Annotation_IDs:CG2286-PB,GB_protein:AAN09230.1,REFSEQ:NP_727255,GB_protein:AAN09230; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • NADH:ubiquinone reductase 75kD subunit, isoform B OS=Drosophila melanogaster GN=ND75 PE=4 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=X:complement(join(8251201..8251383,8250798..8251129,8249703..8250729,8249154..8249642,8248930..8249094)); ID=FBpp0071128; name=ND75-PA; parent=FBgn0017566,FBtr0071180; dbxref=FlyBase:FBpp0071128,FlyBase_Annotation_IDs:CG2286-PA,GB_protein:AAF46356.1,REFSEQ:NP_511083,GB_protein:AAF46356,FlyMine:FBpp0071128,modMine:FBpp0071128; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(8251201..8251383,8250798..8251129,8249703..8250729,8249154..8249642,8248930..8249094)); ID=FBpp0071129; name=ND75-PB; parent=FBgn0017566,FBtr0071181; dbxref=FlyBase:FBpp0071129,FlyBase_Annotation_IDs:CG2286-PB,GB_protein:AAN09230.1,REFSEQ:NP_727255,GB_protein:AAN09230; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(8251201..8251383,8250798..8251129,8249703..8250729,8249154..8249642,8248930..8249094)); ID=FBpp0071128; name=ND-75-PA; parent=FBgn0017566,FBtr0071180; dbxref=FlyBase:FBpp0071128,FlyBase_Annotation_IDs:CG2286-PA,GB_protein:AAF46356.1,REFSEQ:NP_511083,GB_protein:AAF46356,FlyMine:FBpp0071128,modMine:FBpp0071128; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=X:complement(join(8251201..8251383,8250798..8251129,8249703..8250729,8249154..8249642,8248930..8249094)); ID=FBpp0071129; name=ND-75-PB; parent=FBgn0017566,FBtr0071181; dbxref=FlyBase:FBpp0071129,FlyBase_Annotation_IDs:CG2286-PB,GB_protein:AAN09230.1,REFSEQ:NP_727255,GB_protein:AAN09230; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q94511, NADH dehydrogenase (Ubiquinone) 75 kDa subunit, isoform B OS=Drosophila melanogaster GN=ND-75 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0071128 type=protein; loc=X:complement(join(8251201..8251383,8250798..8251129,8249703..8250729,8249154..8249642,8248930..8249094)); ID=FBpp0071128; name=ND-75-PA; parent=FBgn0017566,FBtr0071180; dbxref=FlyBase:FBpp0071128,FlyBase_Annotation_IDs:CG2286-PA,GB_protein:AAF46356.1,REFSEQ:NP_511083,GB_protein:AAF46356,FlyMine:FBpp0071128,modMine:FBpp0071128; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0071129 type=protein; loc=X:complement(join(8251201..8251383,8250798..8251129,8249703..8250729,8249154..8249642,8248930..8249094)); ID=FBpp0071129; name=ND-75-PB; parent=FBgn0017566,FBtr0071181; dbxref=FlyBase:FBpp0071129,FlyBase_Annotation_IDs:CG2286-PB,GB_protein:AAN09230.1,REFSEQ:NP_727255,GB_protein:AAN09230; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(8251201..8251383,8250798..8251129,8249703..8250729,8249154..8249642,8248930..8249094)); ID=FBpp0071128; name=ND-75-PA; parent=FBgn0017566,FBtr0071180; dbxref=FlyBase:FBpp0071128,FlyBase_Annotation_IDs:CG2286-PA,GB_protein:AAF46356.1,REFSEQ:NP_511083,GB_protein:AAF46356,UniProt/Swiss-Prot:Q94511,FlyMine:FBpp0071128,modMine:FBpp0071128; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=X:complement(join(8251201..8251383,8250798..8251129,8249703..8250729,8249154..8249642,8248930..8249094)); ID=FBpp0071129; name=ND-75-PB; parent=FBgn0017566,FBtr0071181; dbxref=FlyBase:FBpp0071129,FlyBase_Annotation_IDs:CG2286-PB,GB_protein:AAN09230.1,REFSEQ:NP_727255,GB_protein:AAN09230,UniProt/Swiss-Prot:Q94511; MD5=0f74f1abf645a3e87a11c2099ddef724; length=731; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 731 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial respiratory chain complex I [ISS]
    mitochondrion [ISS]
    Biological Process: ATP synthesis coupled electron transport [IEA]
    Molecular Function: NADH dehydrogenase activity [ISS]
    electron carrier activity [IEA]
    NADH dehydrogenase (ubiquinone) activity [ISS]
    iron-sulfur cluster binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRAPLVKAL GALGSPTHQM ASRAVRTSAM VAQTPAKAPE KIEVFVDDIP VQVVPGTTVL  60
   61 QAAAQIGVEI PRFCYHERLA VAGNCRMCLV EVEKSPKPVA ACAMPVMKGW RIKTNSDLTR 120
  121 KAREGVMEFL LMNHPLDCPI CDQGGECDLQ DQAMAFGSDR SRFTDINYTG KRAVEDKDIG 180
  181 PLVKTIMTRC IHCTRCVRFA SEIAGVDDLG TTGRGNDMQI GTYVEKLFLT ELSGNVIDLC 240
  241 PVGALTNKPY SFVARPWEIR KVSSIDVLDA VGSNIVVSTR TNEVLRILPR ENEDVNEEWL 300
  301 ADKSRFACDG LKRQRLVAPM VRMPNGELQA VEWEGALIAV AKAIKAAGGQ IAGISGQLAD 360
  361 LEAQVALKDL LNRLGSEVVA TEQGFIAGGT DNRANYLLNS TIAGLEEADA VLLVGTNPRY 420
  421 EAPLVNTRLR KAYVHNELQI ASIGPKIDLS YDHENLGADA ALVKDVCSGA HAFSKVLEGA 480
  481 KKPAIIIGAD LLERADGAAI HATVAEYCKK LKKPNWNPFN VLQTNAAQVG ALDVGYKAGA 540
  541 QTAVKAQPKV LFLLNADAGK VTREQLPKDC FVVYIGSHGD NGASIADAVL PGAAYTEKQG 600
  601 IYVNTEGRPQ QTLPGVSPPG MAREDWKILR ALSEVVGKPL PYDNLDELRN RLEDVAPHLT 660
  661 RLGQLEPAGD AGAAGTISKS IGGGAIDIKL KELRDYFMTD AISRASPTMA KCISAVNKQQ 720
  721 RENEAKQSVA I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..731] PSI-BLAST 89.69897 Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  8.57020397959255 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  8.38566609923386 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  8.21082857163161 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  7.52220758347541 bayes_pls_golite062009
  • oxidoreductase activity
    		•  7.16286065347789 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  7.03780998761655 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  4.68407412780362 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  3.54243134597505 bayes_pls_golite062009
  • oxidoreduction-driven active transmembrane transporter activity
    		•  3.29174700910768 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  3.27019699125535 bayes_pls_golite062009
  • electron carrier activity
    		•  2.86867645862628 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  2.73204059194206 bayes_pls_golite062009
  • metal cluster binding
    		•  2.57357653703854 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  2.57357653703854 bayes_pls_golite062009
  • nitrate reductase activity
    		•  2.20600951698793 bayes_pls_golite062009
  • catalytic activity
    		•  1.93875927205186 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
    		•  1.87673954208357 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  1.84836110501265 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.54181416413094 bayes_pls_golite062009
  • oxidoreductase activity, acting on other nitrogenous compounds as donors
    		•  1.12492792673137 bayes_pls_golite062009
  • binding
    		•  1.0770649921334 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  0.737415967372169 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.67478911167421 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.614505320206825 bayes_pls_golite062009
  • ferrous iron binding
    		•  0.599635746381861 bayes_pls_golite062009
  • cation binding
    		•  0.292059992813768 bayes_pls_golite062009
  • metal ion binding
    		•  0.292059992813768 bayes_pls_golite062009
  • ion binding
    		•  0.285849308897776 bayes_pls_golite062009
  • protein binding
    		•  0.128023487683923 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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