Protein Overview: ND75-PB, ND75-PA

General Information:
Name(s) found:	ND75-PB / FBpp0071129 [FlyBase] ND75-PA / FBpp0071128 [FlyBase]
Description(s) found: Found 38 descriptions. SHOW ALL	The gene NADH:ubiquinone reductase 75kD subunit precursor is referred to in FlyBase by the symbol Dmel\ND75 (CG2286, FBgn0017566). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8142684..8145699. It has the cytological map location 7E1. Based on sequence similarity, it is predicted to have molecular function</span>: NADH dehydrogenase activity; NADH dehydrogenase (ubiquinone) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ATP synthesis coupled electron transport. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene NADH:ubiquinone reductase 75kD subunit precursor is referred to in FlyBase by the symbol Dmel\ND75 (CG2286, FBgn0017566). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8142684..8145699. It has the cytological map location 7E1. Based on sequence similarity, it is predicted to have molecular function</span>: NADH dehydrogenase activity; NADH dehydrogenase (ubiquinone) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ATP synthesis coupled electron transport. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	731 amino acids
Gene Ontology:
Cellular Component:	mitochondrial respiratory chain complex I [ISS] mitochondrion [ISS]
Biological Process:	ATP synthesis coupled electron transport [IEA]
Molecular Function:	NADH dehydrogenase activity [ISS] electron carrier activity [IEA] NADH dehydrogenase (ubiquinone) activity [ISS] iron-sulfur cluster binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRAPLVKAL GALGSPTHQM ASRAVRTSAM VAQTPAKAPE KIEVFVDDIP VQVVPGTTVL  60
   61 QAAAQIGVEI PRFCYHERLA VAGNCRMCLV EVEKSPKPVA ACAMPVMKGW RIKTNSDLTR 120
  121 KAREGVMEFL LMNHPLDCPI CDQGGECDLQ DQAMAFGSDR SRFTDINYTG KRAVEDKDIG 180
  181 PLVKTIMTRC IHCTRCVRFA SEIAGVDDLG TTGRGNDMQI GTYVEKLFLT ELSGNVIDLC 240
  241 PVGALTNKPY SFVARPWEIR KVSSIDVLDA VGSNIVVSTR TNEVLRILPR ENEDVNEEWL 300
  301 ADKSRFACDG LKRQRLVAPM VRMPNGELQA VEWEGALIAV AKAIKAAGGQ IAGISGQLAD 360
  361 LEAQVALKDL LNRLGSEVVA TEQGFIAGGT DNRANYLLNS TIAGLEEADA VLLVGTNPRY 420
  421 EAPLVNTRLR KAYVHNELQI ASIGPKIDLS YDHENLGADA ALVKDVCSGA HAFSKVLEGA 480
  481 KKPAIIIGAD LLERADGAAI HATVAEYCKK LKKPNWNPFN VLQTNAAQVG ALDVGYKAGA 540
  541 QTAVKAQPKV LFLLNADAGK VTREQLPKDC FVVYIGSHGD NGASIADAVL PGAAYTEKQG 600
  601 IYVNTEGRPQ QTLPGVSPPG MAREDWKILR ALSEVVGKPL PYDNLDELRN RLEDVAPHLT 660
  661 RLGQLEPAGD AGAAGTISKS IGGGAIDIKL KELRDYFMTD AISRASPTMA KCISAVNKQQ 720
  721 RENEAKQSVA I

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
NADH dehydrogenase activity	8.57020397959255	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	8.38566609923386	bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity	8.21082857163161	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	7.52220758347541	bayes_pls_golite062009
oxidoreductase activity	7.16286065347789	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	7.03780998761655	bayes_pls_golite062009
formate dehydrogenase activity	4.68407412780362	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	3.54243134597505	bayes_pls_golite062009
oxidoreduction-driven active transmembrane transporter activity	3.29174700910768	bayes_pls_golite062009
succinate dehydrogenase activity	3.27019699125535	bayes_pls_golite062009
electron carrier activity	2.86867645862628	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	2.73204059194206	bayes_pls_golite062009
metal cluster binding	2.57357653703854	bayes_pls_golite062009
iron-sulfur cluster binding	2.57357653703854	bayes_pls_golite062009
nitrate reductase activity	2.20600951698793	bayes_pls_golite062009
catalytic activity	1.93875927205186	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	1.87673954208357	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.84836110501265	bayes_pls_golite062009
carboxy-lyase activity	1.54181416413094	bayes_pls_golite062009
oxidoreductase activity, acting on other nitrogenous compounds as donors	1.12492792673137	bayes_pls_golite062009
binding	1.0770649921334	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.737415967372169	bayes_pls_golite062009
carbon-carbon lyase activity	0.67478911167421	bayes_pls_golite062009
transition metal ion binding	0.614505320206825	bayes_pls_golite062009
ferrous iron binding	0.599635746381861	bayes_pls_golite062009
cation binding	0.292059992813768	bayes_pls_golite062009
metal ion binding	0.292059992813768	bayes_pls_golite062009
ion binding	0.285849308897776	bayes_pls_golite062009
protein binding	0.128023487683923	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..731]	PSI-BLAST	89.69897	Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

Protein Overview: ND75-PB, ND75-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: