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Protein Overview: Trxr-1-PB

General Information:
Name(s) found: Trxr-1-PB / FBpp0071116 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Thioredoxin reductase-1 is referred to in FlyBase by the symbol Dmel\Trxr-1 (CG2151, FBgn0020653). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8136517..8142072. It has the cytological map location 7D22-7E1. There is experimental evidence that it has the molecular function</span>: glutathione-disulfide reductase activity; thioredoxin-disulfide reductase activity; antioxidant activity; protein homodimerization activity. There is experimental evidence that it is involved in the biological process</span>: response to hypoxia; cellular response to DNA damage stimulus; determination of adult lifespan. 20 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 596 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA][NAS]
    mitochondrion [IDA]
    Biological Process: response to hypoxia [IMP]
    determination of adult lifespan [IMP][TAS]
    cell redox homeostasis [IC][IEA]
    oxidation reduction [IEA]
    response to DNA damage stimulus [IMP]
    Molecular Function: NADP or NADPH binding [IEA]
    protein homodimerization activity [IDA]
    antioxidant activity [IDA][NAS]
    FAD binding [IEA]
    glutathione-disulfide reductase activity [IDA][IMP][NAS]
    thioredoxin-disulfide reductase activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLCNSRFSV TFVRQCSTIL TSPSAGIIQN RGSLTTKVPH WISSSLSCAH HTFQRTMNLT  60
   61 GQRGSRDSTG ATGGNAPAGS GAGAPPPFQH PHCDRAAMYA QPVRKMSTKG GSYDYDLIVI 120
  121 GGGSAGLACA KEAVLNGARV ACLDFVKPTP TLGTKWGVGG TCVNVGCIPK KLMHQASLLG 180
  181 EAVHEAAAYG WNVDEKIKPD WHKLVQSVQN HIKSVNWVTR VDLRDKKVEY INGLGSFVDS 240
  241 HTLLAKLKSG ERTITAQTFV IAVGGRPRYP DIPGAVEYGI TSDDLFSLDR EPGKTLVVGA 300
  301 GYIGLECAGF LKGLGYEPTV MVRSIVLRGF DQQMAELVAA SMEERGIPFL RKTVPLSVEK 360
  361 QDDGKLLVKY KNVETGEEAE DVYDTVLWAI GRKGLVDDLN LPNAGVTVQK DKIPVDSQEA 420
  421 TNVANIYAVG DIIYGKPELT PVAVLAGRLL ARRLYGGSTQ RMDYKDVATT VFTPLEYACV 480
  481 GLSEEDAVKQ FGADEIEVFH GYYKPTEFFI PQKSVRYCYL KAVAERHGDQ RVYGLHYIGP 540
  541 VAGEVIQGFA AALKSGLTIN TLINTVGIHP TTAEEFTRLA ITKRSGLDPT PASCCS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] PSI-BLAST 18.221849 Dihydropyrimidine dehydrogenase, N-terminal domain; Dihydropyrimidine dehydrogenase, domain 4; Dihydropyrimidine dehydrogenase, domain 3; Dihydropyrimidine dehydrogenase, domain 2; Dihydropyrimidine dehydrogenase, C-terminal domain
    2 View Details [100..596] PSI-BLAST 107.0 No description for 2nvkX was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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