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Protein Overview: FBpp0309125, FBp...

General Information:
Name(s) found: FBpp0309125 [FlyBase]
FBpp0309124 [FlyBase]
Gclc-PB / FBpp0089361 [FlyBase]
Gclc-PA / FBpp0071063 [FlyBase]
Description(s) found:
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  • gi|7290879|gb|AAF46321.1| Glutamate-cysteine ligase catalytic subunit, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|45554453|ref|NP_996373.1| Glutamate-cysteine ligase catalytic subunit, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|45446853|gb|AAS65282.1| Glutamate-cysteine ligase catalytic subunit, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|24640503|ref|NP_525005.2| Glutamate-cysteine ligase catalytic subunit, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|22653745|sp|Q9W3K5.1|GSH1_DROME RecName: Full=Glutamate--cysteine ligase; AltName: Full=Gamma-glutamylcysteine synthetase; AltName: Full=Gamma-ECS; Short=GCS [NCBI NR]
  • gi|17946344|gb|AAL49208.1| RE64116p [Drosophila melanogaster] [NCBI NR]
  • Glutamate--cysteine ligase OS=Drosophila melanogaster GN=Gclc PE=2 SV=1 [Swiss-Prot]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0309125; name=Gclc-PD; parent=FBgn0040319,FBtr0340139; dbxref=FlyBase:FBpp0309125,FlyBase_Annotation_IDs:CG2259-PD; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0309124; name=Gclc-PC; parent=FBgn0040319,FBtr0340138; dbxref=FlyBase:FBpp0309124,FlyBase_Annotation_IDs:CG2259-PC; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r5.56; species=Dmel; [FlyBase]
  • The gene Glutamate-cysteine ligase catalytic subunit is referred to in FlyBase by the symbol Dmel\Gclc (CG2259, FBgn0040319). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:7996613..8010177. It has the cytological map location 7D6. There is experimental evidence that it has the molecular function</span>: glutamate-cysteine ligase activity; protein binding. There is experimental evidence that it is involved in the biological process</span>: cellular response to DNA damage stimulus; glutathione biosynthetic process; glutathione metabolic process. 7 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG2259-PA translation from_gene[CG2259 Gclc FBgn0040319] seq_release:3 mol_weight=80747 cds_boundaries:(X:7,842,481..7,844,838[-]) aa_length:717 transcript_info:[CG2259-RA seq_release:3] gene_info:[gene symbol:Gclc FBgn0040319 gene_boundaries:(X:7,841 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W3K5) Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) [DrosMelano7227.FASTAC.txt]
  • (AE003442) Gcs gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG2259-PB, isoform B [Drosophila melanogaster]gi|7290879|gb|AAF46321.1| CG2259-PA, isoform A [Drosophila melanogaster]gi|17946344|gb|AAL49208.1| RE64116p [Drosophila melanogaster]gi|45554453|ref|NP_996373.1| CG2259-PB [Drosophila melanogaster]gi|24640 [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0071063; name=Gclc-PA; parent=FBgn0040319,FBtr0071107; dbxref=FlyBase:FBpp0071063,FlyBase_Annotation_IDs:CG2259-PA,GB_protein:AAF46321.1,REFSEQ:NP_ [fly-100309-contam.fasta]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0089361; name=Gclc-PB; parent=FBgn0040319,FBtr0071108; dbxref=FlyBase:FBpp0089361,FlyBase_Annotation_IDs:CG2259-PB,GB_protein:AAS65282.1,REFSEQ:NP_ [fly-100309-contam.fasta]
  • RE64116p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG2259-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG2259-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Glutamate-cysteine ligase catalytic subunit CG2259-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Glutamate--cysteine ligase (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS) [nr-271106-contam.fasta]
  • Glutamate-cysteine ligase catalytic subunit CG2259-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0071063; name=Gclc-PA; parent=FBgn0040319,FBtr0071107; dbxref=FlyBase:FBpp0071063,FlyBase_Annotation_IDs:CG2259-PA,GB_protein:AAF46321.1,REFSEQ:NP_525005,GB_protein:AAF46321; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0089361; name=Gclc-PB; parent=FBgn0040319,FBtr0071108; dbxref=FlyBase:FBpp0089361,FlyBase_Annotation_IDs:CG2259-PB,GB_protein:AAS65282.1,REFSEQ:NP_996373,GB_protein:AAS65282; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0071063; name=Gclc-PA; parent=FBgn0040319,FBtr0071107; dbxref=FlyBase:FBpp0071063,FlyBase_Annotation_IDs:CG2259-PA,GB_protein:AAF46321.1,REFSEQ:NP_525005,GB_protein:AAF46321; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0089361; name=Gclc-PB; parent=FBgn0040319,FBtr0071108; dbxref=FlyBase:FBpp0089361,FlyBase_Annotation_IDs:CG2259-PB,GB_protein:AAS65282.1,REFSEQ:NP_996373,GB_protein:AAS65282; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Glutamate-cysteine ligase catalytic subunit, isoform B OS=Drosophila melanogaster GN=Gclc PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0071063; name=Gclc-PA; parent=FBgn0040319,FBtr0071107; dbxref=FlyBase:FBpp0071063,FlyBase_Annotation_IDs:CG2259-PA,GB_protein:AAF46321.1,REFSEQ:NP_525005,GB_protein:AAF46321,FlyMine:FBpp0071063,modMine:FBpp0071063; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(7997565..7997754,7997821..7998002,7998070..7999226,7999301..7999925); ID=FBpp0089361; name=Gclc-PB; parent=FBgn0040319,FBtr0071108; dbxref=FlyBase:FBpp0089361,FlyBase_Annotation_IDs:CG2259-PB,GB_protein:AAS65282.1,REFSEQ:NP_996373,GB_protein:AAS65282; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0071063; name=Gclc-PA; parent=FBgn0040319,FBtr0071107; dbxref=FlyBase:FBpp0071063,FlyBase_Annotation_IDs:CG2259-PA,GB_protein:AAF46321.1,REFSEQ:NP_525005,GB_protein:AAF46321,FlyMine:FBpp0071063,modMine:FBpp0071063; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0089361; name=Gclc-PB; parent=FBgn0040319,FBtr0071108; dbxref=FlyBase:FBpp0089361,FlyBase_Annotation_IDs:CG2259-PB,GB_protein:AAS65282.1,REFSEQ:NP_996373,GB_protein:AAS65282; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0309124; name=Gclc-PC; parent=FBgn0040319,FBtr0340138; dbxref=FlyBase:FBpp0309124,FlyBase_Annotation_IDs:CG2259-PC,GB_protein:AHN59472,REFSEQ:NP_001285001; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0309125; name=Gclc-PD; parent=FBgn0040319,FBtr0340139; dbxref=FlyBase:FBpp0309125,FlyBase_Annotation_IDs:CG2259-PD,GB_protein:AHN59473,REFSEQ:NP_001285002; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0071063; name=Gclc-PA; parent=FBgn0040319,FBtr0071107; dbxref=FlyBase:FBpp0071063,FlyBase_Annotation_IDs:CG2259-PA,GB_protein:AAF46321.1,REFSEQ:NP_525005,GB_protein:AAF46321,FlyMine:FBpp0071063,modMine:FBpp0071063; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0089361; name=Gclc-PB; parent=FBgn0040319,FBtr0071108; dbxref=FlyBase:FBpp0089361,FlyBase_Annotation_IDs:CG2259-PB,GB_protein:AAS65282.1,REFSEQ:NP_996373,GB_protein:AAS65282; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0309124; name=Gclc-PC; parent=FBgn0040319,FBtr0340138; dbxref=FlyBase:FBpp0309124,FlyBase_Annotation_IDs:CG2259-PC,GB_protein:AHN59472,REFSEQ:NP_001285001; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0309125; name=Gclc-PD; parent=FBgn0040319,FBtr0340139; dbxref=FlyBase:FBpp0309125,FlyBase_Annotation_IDs:CG2259-PD,GB_protein:AHN59473,REFSEQ:NP_001285002; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9W3K5, Glutamate-cysteine ligase catalytic subunit, isoform B OS=Drosophila melanogaster GN=Gclc PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0071063 type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0071063; name=Gclc-PA; parent=FBgn0040319,FBtr0071107; dbxref=FlyBase:FBpp0071063,FlyBase_Annotation_IDs:CG2259-PA,GB_protein:AAF46321.1,REFSEQ:NP_525005,GB_protein:AAF46321,FlyMine:FBpp0071063,modMine:FBpp0071063; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0089361 type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0089361; name=Gclc-PB; parent=FBgn0040319,FBtr0071108; dbxref=FlyBase:FBpp0089361,FlyBase_Annotation_IDs:CG2259-PB,GB_protein:AAS65282.1,REFSEQ:NP_996373,GB_protein:AAS65282; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0309124 type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0309124; name=Gclc-PC; parent=FBgn0040319,FBtr0340138; dbxref=FlyBase:FBpp0309124,FlyBase_Annotation_IDs:CG2259-PC,GB_protein:AHN59472,REFSEQ:NP_001285001; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0309125 type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0309125; name=Gclc-PD; parent=FBgn0040319,FBtr0340139; dbxref=FlyBase:FBpp0309125,FlyBase_Annotation_IDs:CG2259-PD,GB_protein:AHN59473,REFSEQ:NP_001285002; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0071063; name=Gclc-PA; parent=FBgn0040319,FBtr0071107; dbxref=FlyBase:FBpp0071063,FlyBase_Annotation_IDs:CG2259-PA,GB_protein:AAF46321.1,REFSEQ:NP_525005,GB_protein:AAF46321,UniProt/Swiss-Prot:Q9W3K5,FlyMine:FBpp0071063,modMine:FBpp0071063; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0089361; name=Gclc-PB; parent=FBgn0040319,FBtr0071108; dbxref=FlyBase:FBpp0089361,FlyBase_Annotation_IDs:CG2259-PB,GB_protein:AAS65282.1,REFSEQ:NP_996373,GB_protein:AAS65282,UniProt/Swiss-Prot:Q9W3K5; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0309124; name=Gclc-PC; parent=FBgn0040319,FBtr0340138; dbxref=FlyBase:FBpp0309124,FlyBase_Annotation_IDs:CG2259-PC,GB_protein:AHN59472,REFSEQ:NP_001285001,UniProt/Swiss-Prot:Q9W3K5; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=X:complement(join(8105268..8105892,8104037..8105193,8103788..8103969,8103532..8103721)); ID=FBpp0309125; name=Gclc-PD; parent=FBgn0040319,FBtr0340139; dbxref=FlyBase:FBpp0309125,FlyBase_Annotation_IDs:CG2259-PD,GB_protein:AHN59473,REFSEQ:NP_001285002,UniProt/Swiss-Prot:Q9W3K5; MD5=0677b8e76b348197623e8237cce8cec4; length=717; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 717 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    glutamate-cysteine ligase complex [IPI][ISS]
    perinuclear region of cytoplasm [IDA]
    Biological Process: glutathione metabolic process [IDA]
    glutathione biosynthetic process [IDA]
    response to DNA damage stimulus [IMP]
    Molecular Function: protein binding [IPI]
    glutamate-cysteine ligase activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLSEGSPL SWEETKALAD HVREHGVNQF INLYHRLKDR QGDILKWGDE VEYIIVKFDD  60
   61 EQKVARVALR AQDLLAQLNE KELADPNGVK SLWRPEYGAY MIEGTPGKPF GGLMAHFNLV 120
  121 EANMRYRREE VTELLAKDEC VMSITNFPRL GAPNFTYPLA QPRPEDPLSS ARSLYFPDEA 180
  181 IFPGHPRFKT LTRNIRKRRG EKVSIKLKVF KDTKTKLPVE GAPPGEPDVV LLDAMGFGMG 240
  241 CCCLQLTFQA CNITEARRLY DQLAPLCPIM LALTAASPIY RGYLTESDCR WNVISSSVDC 300
  301 RTEEERGLAP LDQQKFRIAK SRYDSIDSYL SPEGAKYNDV PLTYDEKVYQ RLVEGGIDHL 360
  361 LAQHVAHLFI RDTVSLFSEK VHQNDNEDTD HFENIQSTNW QTMRFKPPPP NSSIGWRVEF 420
  421 RPCEAQISDF ENAAIVCFVV LLTRVILSYQ LNFLTPISKV DENMQTAQKR DACRKEKFWF 480
  481 RKSSKTTEQR AAKAQAQAQA QAKAQAQTNG KATLNGNGLA NGNGNGSENS DQEEQQPLTN 540
  541 GSAKMNGHGS GTTNGTNGSS NGSSNGTDSD HTDTDDEENE LFQLLSINEI FNGKPNVFPG 600
  601 LVPLIRSYLQ SMEVDTDTHC TIEQYLRFIQ KRAAGELITT ATWMREQVLS HPDYKQDSVV 660
  661 SERINYDLLK RIQGIQEGKQ VEPALLGQDY HSKTKTKDFI PPALQKQLAK NGCCEEK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..490] FFAS03 1.52 No description for 2gwcA was found.
    2 View Details [491..579] deduced N/A No confident structure predictions are available.
    3 View Details [580..717] MSA 1.014962 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle