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Protein Overview: Dok-PA

General Information:
Name(s) found: Dok-PA / FBpp0071008 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Downstream of kinase is referred to in FlyBase by the symbol Dmel\Dok (CG2079, FBgn0029944). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:7218251..7222848. It has the cytological map location 7B1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: insulin receptor binding. There is experimental evidence that it is involved in the biological process</span>: dorsal closure, elongation of leading edge cells; dorsal closure; stress-activated protein kinase signaling pathway; imaginal disc fusion, thorax closure; imaginal disc-derived wing morphogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: orbital bristle; interommatidial bristle; chaeta; embryonic heart; wing; thorax. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 622 amino acids

    Gene Ontology:
    Cellular Component: cell cortex [IDA]
    Biological Process: dorsal closure [IMP]
    imaginal disc fusion, thorax closure [IMP]
    stress-activated protein kinase signaling pathway [IMP]
    dorsal closure, elongation of leading edge cells [IMP]
    imaginal disc-derived wing morphogenesis [IMP]
    Molecular Function: insulin receptor binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVEIPVLAG YLNVPTQTGF SLNRISKKKA CSRYCLLFKA SRHGIARLEM CESKEDRNPK  60
   61 IFTLENCVKI TQEPPPERLI HIVKRQATLT LSTSSEEELK DWITALQTVA FCDTSPSGGI 120
  121 GAIEEDNDLY CSSFDGLFII TLIPSEASIR CCIEPKTYML QMTPTELQLK SEDLGATIAM 180
  181 WPYRFIRKYG YRDGKFTFEA GRKCTTGEGV FTLDHTNPQE VFRCMSAKMK SMKKLISGDS 240
  241 LSTLECGENQ FSAAAGMEPG SRSPLPPSPS SNPHGGEFEI NSTQSCISLR GFISSNDSLN 300
  301 NFSAGGGGAS GATATGGGVL GSTGGITLSV PANSNSNSSS SKHIPNKPPR KSPTTHCDKY 360
  361 RNIVKYEPVA ITTISSPSAN SDVNSSVILK PLEGESISLP ETAADLPPDL PLRNESASKA 420
  421 PPPERDYECI ENITEAWRTR GVGDVRHSER MPILCDTSEF VRQRSVSKST CGSQNTPKII 480
  481 DIDIGEGCTS ATSISESNYD RLDFLSPNNK TSSGYKTIVN VTPGNRIRCS PPPPNEYELI 540
  541 ASPDTESFRK ADDSHRGYGV LRKASTTTNN NNLGISNSNI SGGSSTITTA TANKGGNLEA 600
  601 AAIDHRSYNG LNYTMVSKPK RV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] PSI-BLAST 60.522879 Insulin receptor substrate 1, IRS-1
    2 View Details [239..337] deduced N/A No confident structure predictions are available.
    3 View Details [338..531] MSA 7.215997 View MSA. No confident structure predictions are available.
    4 View Details [532..622] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.65091781683225 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.36862097678996 bayes_pls_golite062009
  • actin binding
    		•  2.33076715684475 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • actin filament binding
    		•  1.07760654703512 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.189879136353541 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle